The Epidemiology of Vertebral Osteomyelitis in the United States From 1998 to 2013

Issa, Kimona; Diebo, Bassel G.; Faloon, Michael; Naziri, Qais; Pourtaheri, Sina; Paulino, Carl B.; Emami, Arash

doi:10.1097/bsd.0000000000000597

Cited by 105 publications

(123 citation statements)

References 27 publications

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“…Vertebral osteomyelitis or spinal osteomyelitis is an uncommon variant of osteomyelitis, causing 3% to 5% of all osteomyelitis each year [1]. Direct inoculation is not common, but hematogenous spread from other infectious foci can directly spread to the vertebra.…”

Section: Introductionmentioning

confidence: 99%

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Eikenella Corrodens Vertebral Osteomyelitis in a Young Patient With Type I Diabetes Mellitus

Ranabhat¹,

Bhatta²,

Bhatta³

et al. 2020

Cureus

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Vertebral osteomyelitis is an uncommon variant of osteomyelitis. Although Staphylococcus and/or Streptococcus are commonly associated, alternate pathogens have been implicated in vertebral osteomyelitis, especially in endemic areas and/or immunocompromised patients. Here, we present a case of a young African American female with type I diabetes mellitus who presented to us with worsening back pain. The MRI lumbar spine was suggestive of vertebral osteomyelitis involving the right facet joint of the fifth lumbar (L5) and the first spinal (S1) joint and a significant narrowing of the thecal sac at the L4-L5 vertebral level with an anterior epidural abscess. The patient was started on empirical antibiotics, and surgical intervention was performed with L4-L5 laminectomy and extraction of the epidural abscess. Her pus culture showed Eikenella corrodens as a possible cause of vertebral osteomyelitis. She had an uneventful recovery after two weeks of antibiotics (intravenous ceftriaxone) therapy.

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Section: Introductionmentioning

confidence: 99%

“…Direct inoculation is not common, but hematogenous spread from other infectious foci can directly spread to the vertebra. Vertebral osteomyelitis could lead to severe complications, like motor weakness, paralysis, or meningitis, with a high mortality rate (11% per year) [1,2].…”

Section: Introductionmentioning

confidence: 99%

Eikenella Corrodens Vertebral Osteomyelitis in a Young Patient With Type I Diabetes Mellitus

Ranabhat¹,

Bhatta²,

Bhatta³

et al. 2020

Cureus

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“…Vertebral osteomyelitis is an infectious disease can be developed by pyogenic, tuberculous, or brucellar causes [1]. The annual incidence of hospitalization with pyogenic vertebral osteomyelitis (PVO) in the United States between 1998 and 2013 rose from 2.9 to 5.4 per 100,000 individuals [2]. There is still no clear guidance regarding the duration and administration route of antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial therapy and assessing therapeutic response in culture-negative pyogenic vertebral osteomyelitis: a retrospective comparative study with culture-positive pyogenic vertebral osteomyelitis

Kim

Jeon³

2020

Preprint

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Background There are still controversies over the treatment and outcomes in culture-negative pyogenic vertebral osteomyelitis (PVO). The purpose of this study is to investigate the antimicrobial therapy, assessment of therapeutic response, and outcome of culture-negative PVO compared to culture-positive PVO. Methods Retrospective study was performed with non-surgical lumbar PVO. The patients were divided into two groups based on the causative bacterial identification (CN group with culture-negative and CP group with culture-positive). The clinical features, use of antibiotics, laboratory data, and outcomes were compared between the two groups. Results Seventy-three patients with 41 (56.2%) of the CN group and 32 (43.8%) of the CP group were enrolled. Group CN showed a shorter duration of parenteral antibiotics (45.88 ± 16.14 vs. 57.31 ± 24.39, p = 0.019) although a tendency of prolonged duration of total (parenteral + oral) antibiotics (101.17 ± 52.84 vs. 84.19 ± 50.29 days, p = 0.168). When parenteral antibiotics were discontinued or switched to oral antibiotics, erythrocyte segmentation rate (ESR, normal range: < 20 mm/h), C-reactive protein (CRP, normal range: < 0.5 mg/dL), and visual analogue scale (VAS) score for back pain were 42.86 ± 24.05 mm/h, 0.91 ± 1.18 mg/dL, and 4.05 ± 1.07, respectively, with no significant differences between the two groups. The recurrence rates of CN and CP groups were 7.3% (3/41) and 6.3% (2/32), respectively (p = 1.000). Conclusions CN group required a shorter duration of parenteral antibiotics than CP group. Discontinuation of parenteral antibiotics or changing administration route can be considered based on the values of ESR, CRP, and VAS score for back pain.

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“…The majority of spondylodiscitis cases are treated conservatively with 10–20% managed surgically [ 1 ]. Surgical management is indicated in cases when there is a disease reoccurrence despite appropriate medical management with antibiotic therapy, neurological deficit, intractable pain, epidural abscess, as well as progressive vertebral body destruction and/or spinal deformity [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…The incidence of VO has risen in recent years with increased risk correlated with co-morbidities and serious medical illness [ 3 ]. Previous reports have indicated cervical spine VO accounts for 3 to 11% of VO cases [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Post-infectious ankylosis of the cervical spine in an army veteran: a case report

et al. 2018

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BackgroundVertebral osteomyelitis is a rare, life-threatening condition. Successful management is dependent on prompt diagnosis and management with intravenous antibiotic therapy or surgery in addition to antibiotics. Reoccurrence is minimal after 1 year. However, very little is reported in the conservative spine literature regarding the long-term follow-up and the changes to the spine following management of the spinal infection. We report the dramatic radiologic findings of the long-term sequela of a cervical spine infection following a gunshot wound from 1969. Most impressive to the spine specialist is this patient’s ability to return to work despite significant alterations to spinal biomechanics.Case presentationA 69 year-old caucasian male presented to the chiropractic clinic at a Veterans Affairs Medical Center with complaint of chronic left shoulder pain secondary to an associated full thickness tear of the left infraspinatus. An associated regional assessment of the cervical spine ensued. Radiological imaging on file revealed ankylosis C2/C3 to C7/T1. The patient reported a history of multiple fragment wounds in 1969 to the left anterior neck and shoulder 45 years earlier. Osteomyelitis of the cervical spine resulted from the wounds.ConclusionPotential sequela of osteomyelitis is ankylosis of affected joints. In this particular case, imaging provides evidence of regional ankylosis of the cervical spine. Considering the patient did not complain of cervical pain or related symptoms apart from lack of cervical range of motion, and his Neck Disability Index score was 2 out of 50 (4%), no intervention was provided to the cervical spine. The patient reported he self-managed well, worked full-time as a postal worker after he was discharged due to the injury to his neck, and planned to retire in less than one month at age 70. The patient demonstrates successful return to work with pending retirement at age 70 following spondylodiscitis and subsequent ankylosis of the cervical region.

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The Epidemiology of Vertebral Osteomyelitis in the United States From 1998 to 2013

Abstract: This condition is associated with lengthy and expensive hospital stays resulting in a significant burden to patients and the health care system.

Cited by 105 publications

References 27 publications

Eikenella Corrodens Vertebral Osteomyelitis in a Young Patient With Type I Diabetes Mellitus

Eikenella Corrodens Vertebral Osteomyelitis in a Young Patient With Type I Diabetes Mellitus

Antimicrobial therapy and assessing therapeutic response in culture-negative pyogenic vertebral osteomyelitis: a retrospective comparative study with culture-positive pyogenic vertebral osteomyelitis

Post-infectious ankylosis of the cervical spine in an army veteran: a case report

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