The epidemiology of venous thromboembolism in Caucasians and African-Americans: the GATE Study

Dowling, Nicole F.; Austin, Harland; Dilley, Anne; Whitsett, Carolyn; Evatt, Bruce L.; Hooper, W. Craig

doi:10.1046/j.1538-7836.2003.00031.x

Cited by 142 publications

(167 citation statements)

References 29 publications

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“…This is in agreement with familial studies of defined genetic defects, in which approximately 50% of cases involving a first thrombotic event are unprovoked [35][36][37]. Acquired risk factors are usually not taken into account when considering the overall importance of a family history of VTE [6,41,42], although familial risks have been estimated in unprovoked VTE cases by Couturaud et al [45].…”

Section: Familial History and Unusual Forms Of Vtesupporting

confidence: 78%

Familial risks of unusual forms of venous thrombosis: a nationwide epidemiological study in Sweden

Zöller

Sundquist

et al. 2010

Journal of Internal Medicine

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Zöller B, Li X, Sundquist J, Sundquist K. (Center for Primary Health Care Research, Lund University, Malmö, Sweden; Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA). Familial risks of unusual forms of venous thrombosis: a nationwide epidemiological study in Sweden. J Intern Med 2011; 270: 158–165. Abstract. Objective. This is the first nationwide study to determine familial risks of unusual forms of venous thrombosis amongst offspring of affected parents and amongst siblings. Design and settings. The Swedish Multigeneration Register of 0‐ to 75‐year‐old subjects was linked to the Hospital Discharge Register for the period 1987–2007. Standardized incidence ratios (SIRs) were calculated for individuals whose relatives were hospitalized for venous thromboembolism (VTE), as determined by the International Classification of Diseases, compared to those whose relatives were not affected by VTE. Results. The total number of hospitalized patients with VTE was 45 362, of which 1824 (4.0%) were affected by a rare thrombotic condition. The familial SIRs in cases with a history of VTE in parents or siblings were significantly increased for migrating thrombophlebitis (1.81; 95% confidence interval (CI) 1.40–2.31), portal vein thrombosis (2.35; 95% CI 1.77–3.06), vena cava thrombosis (1.96; 95% CI 1.42–2.64) and cerebral venous thrombosis (1.74; 95% CI 1.30–2.28). Budd–Chiari syndrome (SIR, 0.92; 95% CI 0.24–2.38) and renal vein thrombosis (SIR, 1.72; 95% CI 0.62–3.77) were not significantly associated with parental or sibling history of VTE; however, these two conditions were very rare, and therefore, we cannot draw any definite conclusions from this finding. Conclusions. Family history is an important risk factor for most unusual forms of VTE. Moreover, even the paraneoplastic phenomenon, migrating thrombophlebitis (Trousseau’s syndrome), is associated with a family history of VTE. Thus, our data suggest that most rare forms of VTE have a familial background.

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Section: Familial History and Unusual Forms Of Vtesupporting

confidence: 78%

Familial risks of unusual forms of venous thrombosis: a nationwide epidemiological study in Sweden

Zöller

Sundquist

et al. 2010

Journal of Internal Medicine

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“…The GATE study design and characteristics have been previously described in detail [17,18]. Briefly, cases were adult patients 18-70 years of age who were admitted to one of two university hospitals in Atlanta, Georgia during between 1998 and 2005 and were diagnosed with a first or recurrent VTE.…”

Section: Study Population and Clinical Definitionsmentioning

confidence: 99%

“…Confirmation of PE was made by positive angiogram, ventilation-perfusion lung scan, or CT. Patients with severe illness or with cognitive deficits were excluded [17].…”

Section: Study Population and Clinical Definitionsmentioning

confidence: 99%

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Increased risk of venous thromboembolism is associated with genetic variation in heme oxygenase-1 in Blacks

Bean¹,

Boulet²,

Ellingsen³

et al. 2012

Thrombosis Research

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Background-Venous thromboembolism (VTE) affects as many as 1 in 1000 individuals in the United States. Although Blacks are disproportionately affected by VTE, few genetic risk factors have been identified in this population. The inducible heme oxygenase-1 (HMOX1) gene encodes a key cytoprotective enzyme with anti-inflammatory, antioxidant and anticoagulant activity acting in the vascular system. A (GT) n microsatellite located in the promoter of the HMOX1 gene influences the level of response.

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“…Clinical characteristics varied between Blacks and Whites when the two races were compared. Cancer, recent surgery and immobilization were more common among Caucasians, whereas hypertension, diabetes, and kidney disease were more prevalent among African Americans [5].…”

mentioning

confidence: 98%

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2010

American J Hematol

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The epidemiology of venous thromboembolism in Caucasians and African-Americans: the GATE Study

Cited by 142 publications

References 29 publications

Familial risks of unusual forms of venous thrombosis: a nationwide epidemiological study in Sweden

Familial risks of unusual forms of venous thrombosis: a nationwide epidemiological study in Sweden

Increased risk of venous thromboembolism is associated with genetic variation in heme oxygenase-1 in Blacks

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