The epidemiology of systemic lupus erythematosus: Preliminary results in New York City

Siegel, Morris; Lee, Stanley L.; Widelock, Daniel; Reilly, Edith Bramwell; Wise, Gilbert J.; Zingale, Salvador B.; Fuerst, Harold T.

doi:10.1016/0021-9681(62)90063-2

Cited by 59 publications

(13 citation statements)

References 11 publications

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“…This possibility has been suggested by the findings of serological and clinical abnormalities in the kindred of patients with systemic lupus erythematosus and rheumatoid arthritis (17)(18)(19)(20).…”

Section: Discussionmentioning

confidence: 97%

Antibody Production in Rheumatic Diseases. The Effect of Brucella Antigen*

Meiselas¹,

Zingale²,

Lee³

et al. 1961

J. Clin. Invest.

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The possibility that a disordered immune response is related to the development of the rheumatic diseases has been an attractive hypothesis for investigation for years. Several investigators have attempted to demonstrate quantitative differences in the immune response between patients with these diseases and control subjects when they were inoculated with various antigens. Rantz, Creger and Choy (1) challenged patients with rheumatic fever and rheumatoid arthritis by injecting isologous red blood cells intravenously, and by the inoculation of influenza A and B vaccine. The patients with rheumatic fever responded with an increased titer of isohemagglutinins and in increased titer of antibodies to influenza virus compared with the control groups. There was no difference in the immune response to these two antigens between the rheumatoid arthritic patients and control subjects. In a prospective study, Rejholec (2) administered brucella vaccine subcutaneously to a group of 900 children. A small group developed very high titers of brucella antibody, measured by the indirect Coombs technique. All the children were followed clinically and a very high percentage of the hyper-reactors were shown subsequently to develop rheumatic fever; indeed, the only cases of rheumatic fever appeared in this hyper-reactor group. Miller, Kibrick, and Massel (3), by using influenza virus and typhoid. 0 and H antigens, were unable to show hyperreactivity in a group of patients with rheumatic *

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Section: Discussionmentioning

confidence: 97%

Antibody Production in Rheumatic Diseases. The Effect of Brucella Antigen*

Meiselas¹,

Zingale²,

Lee³

et al. 1961

J. Clin. Invest.

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“…They may be true 'autoimmune' diseases of clonic type, which would not occur in populations with T-cell deficiency. This would explain the peak frequency of disseminated lupus erythema todes in patients between 15 and 54 years of age [9], in whom the cellmediated immunity would be at its highest level and the decline in fre quency in older age groups, after T-cell function starts to lag [20]. This cannot be true for rheumatoid arteritis which increases in frequency with age.…”

Section: Discussionmentioning

confidence: 84%

“…The absence of disseminated lupus erythematodes in Shiraz and the prominence of the disease in the USA [9] as well as the high frequency of acute rheumatic disease in Iran and the persistent decline in frequency in the USA to its virtual extinction during the last decades beg for an explanation.…”

Section: Discussionmentioning

confidence: 99%

Geographic Patterns of Immunity and Vascular Disease

Dutz¹,

Rossipal²,

Ghavami³

et al. 1975

Pathobiology

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“…If the incidence is based on the last five years of the study when the recognition of cases was more complete because of broader application of modern diagnostic methods, the rates are about 25 per cent to 50 per cent higher than those shown in Table 2. On this basis, the highest current incidence of the disease in females 15 to 44 was 10.8 per 100,000 for Negroes, 6.7 for Puerto Ricans, and 3.4 for whites.…”

mentioning

confidence: 99%

“…Thus far the data have been limited to the occasional report of multiple cases in the same family, the random distribution of cases by birth order, the increased frequency of abnormal immunological reactions in patients and some of their family members, and the occurrence of the disease in agammaglobulinemia, a genetically determined condition. [4][5][6][7] Our limited knowledge of the nature of systemic lupus erythematosus and its associated conditions has been obtained by clinical and laboratory studies largely based on the patient alone and, in some instances, on his family members. Such studies have been restricted by lack of knowledge of the general population of which the patient is part.…”

mentioning

confidence: 99%