Rabbits have been categorised as low-risk animals for transmitting rabies. A case of a domestic rabbit (Oryctolagus cuniculus) with naturally acquired rabies infection that was diagnosed on postmortem using an Immunochromatographic test, Fluorescent Antibody Test, and RT-PCR has been reported here and its public health implications have been discussed. The report highlighted the importance of decision-making on the need of vaccinations in human exposure situations with these animals in endemic areas on a case-to-case basis.