The Epidemiology of Panic Attacks, Panic Disorder, and Agoraphobia in the National Comorbidity Survey Replication

Kessler, Ronald C.; Chiu, Wai Tat; Jin, Robert; Ruscio, Ayelet Meron; Shear, Katherine; Walters, Ellen E.

doi:10.1001/archpsyc.63.4.415

Cited by 685 publications

(575 citation statements)

References 48 publications

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“…There is evidence that the age of onset of PD is bimodal (26). The majority have their first panic attack in the twentieths (27) but there is also a group with age of onset between age 50 and 60 (lateonset panic disorder) (26;28;29). It is well documented that PD is associated with physical and social disability, occupational dysfunction, quality of life impairment and health care utilization in psychiatric and primary care patients (30-33).…”

Section: Panic Disordermentioning

confidence: 99%

“…According to the US National Co morbidity Survey Replication, the lifetime prevalence of PD in the general population is estimated to 4.7% and the 12 month prevalence to 2.8 % (27). Furthermore, 3 to 8 % of patients seen by primary care physicians suffer from PD (34).…”

Section: Prevalence Of Panic Disordermentioning

confidence: 99%

“…One cross-sectional study (53) reported that 61% of patients referred for treatment of PD suffer from at least one other anxiety or affective disorder, but the overall co-morbidity decreased when PD was treated. A recent epidemiological study (27) reported that 83% of PD patients without agoraphobia and 100% of PD patients with agoraphobia suffered from at least one other psychiatric disorder and agoraphobia was found in about one fourth of patients with lifetime PD. Co-existence of agoraphobia and PD is far higher in patients seen in psychiatric clinics (75-80%) (32;44;54).…”

Section: Outcome Of Panic Disordermentioning

confidence: 99%

See 2 more Smart Citations

A 1-year follow-up study of chest-pain patients with and without panic disorder

Dammen

Bringager

Arnesen

et al. 2006

General Hospital Psychiatry

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Section: Panic Disordermentioning

confidence: 99%

Section: Prevalence Of Panic Disordermentioning

confidence: 99%

Section: Outcome Of Panic Disordermentioning

confidence: 99%

See 1 more Smart Citation

A 1-year follow-up study of chest-pain patients with and without panic disorder

Dammen

Bringager

Arnesen

et al. 2006

General Hospital Psychiatry

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“…1,2 It is characterized by recurrent, unprovoked and unpredictable panic attacks, followed by concern of subsequent attacks, resulting in a strong social and functional inhibition. 3,4 Estimates from family and twin studies ascribe a genetic contribution of approximately 40% to the disease etiology of the disorder.…”

Section: Introductionmentioning

confidence: 99%

A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene

et al. 2011

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Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors, as well as genetic factors. Despite a significant hereditary component, genetic studies have only been modestly successful in identifying genes of importance for the development of PD. In this study, we conducted a genome-wide scan using microsatellite markers and PD patients and control individuals from the isolated population of the Faroe Islands. Subsequently, we conducted a fine mapping, which revealed the amiloride-sensitive cation channel 1 (ACCN1) located on chromosome 17q11.2-q12 as a potential candidate gene for PD. The further analyses of the ACCN1 gene using singlenucleotide polymorphisms (SNPs) revealed significant association with PD in an extended Faroese case-control sample. However, analyses of a larger independent Danish case-control sample yielded no substantial significant association. This suggests that the possible risk alleles associated in the isolated population are not those involved in the development of PD in a larger outbred population.

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“…Thus, the rate of the disorder is higher in primary care settings, with a reported median prevalence of 4% to 6% (8). Furthermore, the majority of individuals with panic disorder obtain their mental health treatment in the primary care setting (17,18). Despite these findings, research suggests that panic disorder often goes unrecognized (19,20), and inadequately treated in both primary care (8,21-23) and psychiatric settings (24-26).…”

mentioning

confidence: 99%

Psychiatric Treatment Received by Primary Care Patients With Panic Disorder With and Without Agoraphobia

Marcks¹,

Weisberg²,

Keller³

2009

Psychiatric Services

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Objective Although the majority of individuals with panic disorder first present to the primary care setting, little is known about the psychiatric treatment primary care patients with the disorder typically receive. The purpose of the current study was to explore characteristics of treatment received by those with panic disorder with and without agoraphobia, examine demographic and clinical predictors of receiving treatment, and explore treatment barriers. Methods This study uses data from the Primary Care Anxiety Project (PCAP), which is a naturalistic, longitudinal study of anxiety disorders in primary care patients. This study presents data on 235 PCAP participants diagnosed with panic disorder with (N=150) or without agoraphobia (N=85) at the study intake assessment. Results Many patients with panic disorder were not receiving psychiatric treatment at study intake, with those without agoraphobia being less likely to receive treatment. Psychotropic medications were the treatment of choice, with SSRIs/SNRIs being the most commonly received class of medications. Only 39% of those with panic disorder with agoraphobia and 24% of those without agoraphobia were receiving psychotherapy, and use of empirically supported interventions was rare. The most common treatment barriers were: not believing in utilizing medication/therapy for emotional problems and not receiving a treatment recommendation from one’s provider. Conclusions The findings suggest a need for better treatment dissemination, in addition to making interventions more accessible and/or adapting them to the particular needs of primary care patients.

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The Epidemiology of Panic Attacks, Panic Disorder, and Agoraphobia in the National Comorbidity Survey Replication

Abstract: Although the major societal burden of panic is caused by PD and PA-AG, isolated PAs also have high prevalence and meaningful role impairment.

Cited by 685 publications

References 48 publications

A 1-year follow-up study of chest-pain patients with and without panic disorder

A 1-year follow-up study of chest-pain patients with and without panic disorder

A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene

Psychiatric Treatment Received by Primary Care Patients With Panic Disorder With and Without Agoraphobia

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