The Epidemiology of Mould Infections in Argentina: Review and Experience

Dignani, María Cecilia; Davel, Graciela; Refojo, Nicolás; Mazza, Mariana; Córdoba, Susana; Hevia, Alejandra; Abrantes, Rubén; Isla, Guillermina; Fernández, Julián; Rivas, María Cristina; Valledor, Alejandra; Laborde, Ana; Pereyra, M.L. González; Rossi, Inés Roccia

doi:10.1007/s12281-012-0115-9

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…In Argentina, three retrospective surveys on fungal infections were conducted in 2004, 2008, and 2010, and one prospective surveillance between 2010 and 2012 [86,87]. Moreover, in 2018, invasive aspergillosis and chronic pulmonary and allergic bronchopulmonary aspergillosis rates were calculated [88].…”

Section: Epidemiology Of Triazole Resistance In a Fumigatus In Latin American Countriesmentioning

confidence: 99%

“…All studies agreed that A. fumigatus is the most predominant species causing invasive mold disease. Susceptibility testing of the isolates showed low azole MIC values [ 86 , 87 ]. In a 2011 study, 23 isolates of the section Fumigati were characterized and three were ITC resistant (MIC >16 μg/ml), but no further characterization was done [ 89 ].…”

Section: Epidemiology Of Triazole Resistance In a Fumigatus In Latin American Countriesmentioning

confidence: 99%

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Emergence of Triazole Resistance in Aspergillus spp. in Latin America

Macedo

Leonardelli

Gamarra

et al. 2021

Curr Fungal Infect Rep

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Purpose of Review Azole resistance in Aspergillus spp. is becoming a public health problem worldwide. However, data about this subject is lacking in Latin American countries. This review focuses in the epidemiology and molecular mechanisms of azole resistance in Aspergillus spp. emphasizing in Latin America. Data on Aspergillus fumigatus stands out because it is the most prevalent Aspergillus spp. pathogen. Recent Findings Azole resistance in Aspergillus spp. emergence was linked with intensive use of these antifungals both in the clinical setting and in the environment (as pesticides). Reports on azole-resistant A. fumigatus strains are being constantly published in different countries. Molecular mechanisms of resistance mainly involve substitution in the azole target (CYP51A) and/or overexpression of this gene. However, several other non-CYP51A-related mechanisms were described. Moreover, intrinsically resistant cryptic Aspergillus species are starting to be reported as human pathogens. Summary After a comprehensive literature review, it is clear that azole resistance in Aspergillus spp. is emerging in Latin America and perhaps it is underestimated. All the main molecular mechanisms of azole resistance were described in patients and/or environmental samples. Moreover, one of the molecular mechanisms was described only in South America. Cryptic intrinsic azole-resistant species are also described.

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Section: Epidemiology Of Triazole Resistance In a Fumigatus In Latin American Countriesmentioning

confidence: 99%

Section: Epidemiology Of Triazole Resistance In a Fumigatus In Latin American Countriesmentioning

confidence: 99%

Emergence of Triazole Resistance in Aspergillus spp. in Latin America

Macedo

Leonardelli

Gamarra

et al. 2021

Curr Fungal Infect Rep

View full text Add to dashboard Cite

show abstract

“…); causando desde infecciones asintomáticas (las más frecuentes) hasta infecciones pulmonares graves, agudas y crónicas. Por otra parte, H. capsulatum variedad duboisii es endémico de zonas tropicales de África, donde causa infecciones asintomáticas hasta presentaciones clínicas con lesiones óseas y cutáneas (Bonifaz, 2012;Dignani et al, 2012).…”

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