The Epidemiology of Microscopic Colitis in Olmsted County From 2002 to 2010: A Population-Based Study

Abstract

Background & Aims The increasing incidence of microscopic colitis has been partly attributed to diagnostic detection bias. We aimed to ascertain recent incidence trends and the overall prevalence of microscopic colitis in a population-based study. Methods Using data from the Rochester Epidemiology Project, we identified residents of Olmsted County, Minnesota who were diagnosed with collagenous colitis or lymphocytic colitis from January 1, 2002 through December 31, 2010 based on biopsy results and the presence of diarrhea (n=182; mean age at diagnosis, 65.8 y; 76.4% female). Poisson regression analyses were performed to evaluate associations between incidence and age, sex, and calendar period. Results The age- and sex-adjusted incidence of microscopic colitis was 21.0 cases per 100,000 person-years (95% confidence interval [CI], 18.0–24.1 cases per 100,000 person-years). The incidence of lymphocytic colitis was 12.0 per 100,000 person-years (95% CI, 9.6–14.3 per 100,000 person-years) and collagenous colitis was 9.1 per 100,000 person-years (95% CI, 7.0–11.1 per 100,000 person-years). The incidence of microscopic colitis and its subtypes remained stable over the study period (p=.63). Increasing age (p<.001) and female sex (p<.001) were associated with increasing incidence. On December 31, 2010, the prevalence of microscopic colitis was 219 cases per 100,000 persons (90.4 per 100,000 persons for collagenous colitis and 128.6 per 100,000 persons for lymphocytic colitis). Conclusion The incidence of microscopic colitis in Olmsted County residents has stabilized and remains associated with female sex and increasing age.

Irritable Bowel Syndrome and Microscopic Colitis: A Systematic Review and Meta-analysis

“…[28][29][30] It has three key elements: a clinical history of chronic watery diarrhea, normal or almost normal macroscopic appearances of the colon at colonoscopy, and a distinct histological pattern. 31 Microscopic colitis and IBS may therefore share similar presenting symptoms and in both conditions the mucosa at colonoscopy is normal.…”

New insights and challenges in microscopic colitis

“…The increased incidence has stabilized over the past years, and the incidence is associated with female gender and increasing age [Gentile et al 2014]. Reports indicate that MC is more frequent in colder, northern countries than in southern countries [Pardi et al 2007;Fernandez-Banares et al 2011;Gentile et al 2014].…”

Evolution of ideas on microscopic colitis

“…Эпиде-миологические данные, полученные в последние 10 лет, свиде-тельствуют о неуклонном росте распространенности и заболевае-мости МК [12,13]. В настоящее время распространенность МК составляет 103 случая (42 -КК, 69 -ЛК) на 100 000 населения, что сопоставимо с другими воспалительными заболеваниями ки-шечника, такими как язвенный колит (ЯК) и болезнь Крона (БК) [14].…”