The epidemiology of<i>Schistosoma mansoni</i>, hepatitis B and hepatitis C infection in Egypt

Kamel, M. A.; Miller, Freeman D.; Masry, A. G. El; Zakaria, S.; Khattab, Marwa S.; Essmat, G.; Ghaffar, Y. A.

doi:10.1080/00034983.1994.11812897

Cited by 63 publications

(59 citation statements)

References 12 publications

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“…2,9,19,29,30 Among the 13 articles included in the fi nal step of the review, ten were cross-sectional studies, 8,9,19,29,30,36,37,39,40,45 one was a retrospective cases series, 6 one was a prospective cases series 2 and the other was a cases series with an external control group. 32 Five studies 6,32,39,40,45 were conducted in Brazil, fi ve in Egypt, 2,9,19,29,30 two in Sudan, 36,37 one in Ethiopia 8 and one in Kenya. 9 A higher prevalence of HCV infection was found in the SM population of Egypt, compared to the other countries (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…30 Six studies 6,9,29,37,39,40 aimed to evaluate the severity of hepatic lesions and morbidity of hepatitis C when associated with SM and to correlate this with serologic markers. The mean age of humans enrolled in these studies was 33.7 years and in four articles subjects were > 40 years 6,29,32,36 (Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…Six studies did not mention the exclusion criteria adopted. 2,9,19,30,32,36 The most commonly chosen technique of HCV diagnosis was 3 rd generation anti-HCV ELISA, utilized in fi ve studies. 8,9,36,37,45 Four other studies utilized 2 nd generation anti-HCV ELISA.…”

Section: Resultsmentioning

confidence: 99%

“…8,9,36,37,45 Four other studies utilized 2 nd generation anti-HCV ELISA. 2,19,29,30 The quantifi cation of the viral titers was performed by HCV RNA PCR in seven studies. 6,9,29,36,37,39,40 Six studies made appropriate epidemiologic and statistical analyses to confi rm the correlation between risk factors associated and HCV infection in SM patients.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies did not fi nd any association between SM infection and an increased risk of acquiring HCV. 8,30,36,37 …”

Section: Resultsmentioning

confidence: 99%

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Association between Schistosomiasis mansoni and hepatitis C: systematic review

et al. 2013

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OBJECTIVE:To perform a systematic review of the prevalence of the HCV/S. mansoni co-infection and associated factors in Schistosoma mansoni-infected populations. METHODS:The bibliographic search was carried out using the Medline, Lilacs, SciELO, Cochrane Library and Ibecs databases. The criteria for the studies' selection and the extraction data were based on systematic review methods. Forty fi ve studies were found, with nine being excluded in a fi rst screening. Thirteen articles were used for data extraction. RESULTS:The HCV infection rates in schistosomiasis populations range from 1% in Ethiopia to 50% in Egypt. Several studies had poorly defi ned methodologies, even in areas characterized by an association between hepatitis C and schistosomiasis, such as Brazil and Egypt, which meant conclusions were inconsistent. HCV infection rates in schistosomotic populations were heterogeneous and risk factors for acquiring the virus varied widely. CONCLUSIONS:Despite the limitations, this review may help to identify regions with higher rates of hepatitis C and schistosomiasis association. However, more studies are necessary for the development of public health policies on prevention and control of both diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Four studies did not fi nd any association between SM infection and an increased risk of acquiring HCV. 8,30,36,37 …”

Section: Resultsmentioning

confidence: 99%

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Association between Schistosomiasis mansoni and hepatitis C: systematic review

et al. 2013

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Clinical significance of TT virus infection in patients with chronic liver disease and volunteer blood donors in Egypt

Gad¹,

Tanaka²,

Orii³

et al. 2000

J. Med. Virol.

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Clinical significance of TT virus (TTV) infection was investigated in Egyptian patients with chronic liver disease and volunteer blood donors by a cross sectional analysis. TTV DNA in serum was assessed by a semi-nested polymerase chain reaction. The prevalence of TTV DNA did not differ among patients with chronic hepatitis B (11/24, 46%), chronic hepatitis C (22/72, 31%), or schistosomal liver disease (14/39, 36%). No difference in prevalence was found between blood donors (32/109, 29%) and each of the patient groups. Clinical background including mean age, sex distribution, history of blood transfusion, and mean level of alanine aminotransferase did not differ between TTV DNA-positive and -negative individuals in any of the study groups. Ultrasonographic evidence of liver cirrhosis was similar between TTV-positive and -negative patients in each of the chronic liver disease groups. TTV infection was not associated with hepatitis B or C virus infection in blood donors. The only significant difference observed was the lower concentration of serum HCV RNA in TTV DNA positive compared with negative patients with chronic hepatitis C (3.0 +/- 1.4 vs. 4.0 +/- 0.9 log copies/ml, P <. 001). In conclusion, TTV infection was not associated with either past history of blood exposure or infection with bloodborne hepatitis viruses in Egypt. No clinical significance of TTV was found in the present study. However, a reciprocal interaction was suggested between TTV and HCV replication.

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