The epidemiology of hyperuricaemia and gout in Taiwan aborigines

Chou, Chen‐Te; Lai, Jiann–Jyh

doi:10.1093/rheumatology/37.3.258

Cited by 68 publications

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“…The Hmong have undergone a massive and abrupt geographic and cultural translocation. Modernization of other underdeveloped societies, most notably New Zealand Maoris and Taiwanese aborigines, has been associated with the emergence of widespread gout (11)(12)(13)(17)(18)(19). The prevalence of gout in these groups far exceeds that of Western industrialized populations, yet gout was not recognized until their adoption of Western habits.…”

Section: Discussionmentioning

confidence: 99%

“…The Maori are exposed to all major risk factors, including high purine intake, alcohol consumption, obesity, glucose intolerance, and hypertension (17,19,20). Similarly, alcohol, central obesity, diabetes mellitus, and hypertension have been identified as significant risk factors for hyperuricemia and gout in Taiwanese aborigines (12,13,18,(21)(22)(23). Conversely, the prevalence of gout in a Vietnamese urban community was reported as being much lower, at 0.14% (24).…”

Section: Discussionmentioning

confidence: 99%

“…An increased prevalence of gout is noted among indigenous, native populations concurrently with the adoption of a more Western lifestyle (11)(12)(13). A group of newly arrived Americans, the Hmong, initiated immigration following the conclusion of the Vietnam conflict in 1975.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

High prevalence of gouty arthritis among the Hmong population in Minnesota

Portis¹,

Laliberte²,

Tatman³

et al. 2010

Arthritis Care & Research

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Objective. The prevalence of gout is on the rise worldwide, especially among newly industrialized populations. We evaluated the prevalence of gout in the recently established Hmong of Minneapolis/St. Paul (MSP) compared with that in non-Hmong populations. Methods. The prevalence of self-reported gout in the Hmong population was estimated from 2 cross-sectional community surveys and compared with national data extrapolated from the Third National Health and Nutrition Examination Survey. The prevalence of physician-diagnosed gout in Hmong and non-Hmong MSP residents was separately estimated from the diagnosis codes of 11 MSP primary care clinics. Results. The prevalence of self-reported gout among MSP Hmong was 2-fold higher than in the general US population (6.5% versus 2.9%; P < 0.001). Although women of both groups reported gout at a rate of 1.9%, Hmong men were significantly more likely than their non-Hmong counterparts to report gout (11.5% versus 4.1%; P < 0.001). Similar results were observed when investigating physician-diagnosed gout in MSP (2.8% Hmong versus 1.5% non-Hmong; P < 0.001). No difference was observed between the women of the 2 groups (0.8% versus 0.7%; P ‫؍‬ 0.833), whereas Hmong men were more than twice as likely to be diagnosed with gout compared with their non-Hmong counterparts (6.1% versus 2.5%; P < 0.001). Among Hmong men, advancing age was associated with a considerably higher likelihood of being diagnosed with gout. Conclusion. A significant association is observed between Hmong ethnicity and gout, both self-reported and physician diagnosed. This unique population may provide an opportunity to further our understanding of the pathophysiology of gout.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

High prevalence of gouty arthritis among the Hmong population in Minnesota

Portis¹,

Laliberte²,

Tatman³

et al. 2010

Arthritis Care & Research

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show abstract

“…Very high incidence rates of hyperuricemia and gout have been reported in certain Aboriginal people in the Pacific region, with Taiwanese indigenous people having the highest incidence rates (hyperuricemia, 41.4%; gout, 11.7%) [14]. The prevalence of hyperuricemia in the United States (US) has been estimated to be about 23%, with African Americans having higher prevalence than non-African American populations (25.7% vs. 22.1%) [14]. A recent Italian survey study has reported a clear pattern of increasing prevalence of hyperuricemia with time given the cut-off value of 6 mg/dl (360 mol/L) (8.5% in 2005 vs. 11.9% in 2009) [15].…”

Section: Epidemiological Aspects Of Uric Acidmentioning

confidence: 99%

Hyperuricemia and Urologic Disease

Cho

Min

2017

Urogenit Tract Infect

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Gout is a disease that causes painful inflammatory arthritis related to hyperuricemia, due to the incorrect metabolism of uric acid. Decreased renal excretion of urate is thought to be the major hyperuricemic mechanism. Most genes responsible for the serum uric acid (SUA) level encode uric acid transporters or related regulatory proteins. The acquired effects can also modulate SUA level and uric acid excretion, which can result in acute gout. Interestingly, kidney related comorbidities in gout, such as hypertension, chronic kidney disease (CKD), and urolithiasis, all have a fairly high prevalence. Recent advancements in genetics and molecular physiology have greatly improved our understanding of renal reabsorption and secretion of filtered uric acid. Furthermore, the baseline SUA level appears to be established by a net balance between absorption and secretion through the epithelium of the kidneys and intestines. There have also been considerable progress in the management of gout patients with CKD. Increased prevalence of gout with CKD can be balanced by an expanded spectrum of treatment options for this important disease. Another issue is that lowering of the uric acid level can reduce the incidence of cardiovascular disease, renal disease, and urological complications. Basic research and clinical studies on these mechanisms might be helpful in determining the appropriate treatment for hyperuricemic patients. Based on currently existing literature, there have been improvements associated with medications that lower uric acid, particularly xanthine oxidase inhibitors. Here, we review the pathogenesis and epidemiology of hyperuricemia, specific diseases related to uric acid, and up-to-date perspectives on their management.

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“…Prevalensen av hyperurikemi og urinsyregikt i denne befolkningsgruppen er vesentlig høyere med en andel på henholdsvis 53,8% og 26,6% blant mennene. Prevalensen for urinsyregikt blant maorimenn i New Zealand er 13,9%, en prevalens som er 3 ganger høyere enn for europeiske aettede menn (30,31). Disse forekomstene er klart høyere enn forekomsten i de amerikanske og nordiske studiene.…”

Section: Kjønnunclassified

Epidemiologi av urinsyregikt

Skomsvoll¹,

Rødevand²

2009

Nor J Epidemiol

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ENGLISH SUMMARYSkomsvoll JF, Rødevand E. The epidemiology of gout. Nor J Epidemiol 2008; 18 (1): 23-29.Gout is more prevalent in men than in women. However, there is a reduction in the difference in prevalence between men and women after menopause. The incidence is low in young age, but increases with increasing age, particularly after the age of 50. The risk of gout attack is to some extent dependent on the level of the serum concentration of urate. In the last decades the prevalence of gout has increased substantially, probably due to increase in the proportion of people with overweigth, disease promoting lifestyle changes, metabolic syndrome, diabetes and cardiovascular disease (CVD). Hypeuricemia inducing drugs may also play a role. Drugs may play an important role in the treatment of the acute gout attacks. However, changes in lifestyle and diet are important prophylactic efforts. High levels of serum urate may be a risk factor for the development of CVD, but at the moment it is not explored whether the serum urate level is a marker or an independent contributor to the morbidity and mortality of CVD. HISTORIENUrinsyregikt har vaert kjent fra antikken og er beskrevet av Hippocrates. Sykdommen ble tidligere betraktet som en sykdom blant rike middelaldrende menn, ofte historisk kjente personer som konger, kunstnere, statsog vitenskapsmenn. Mennesket er det eneste pattedyret hvor urinsyregikt utvikler seg spontant, fordi det mangler enzymet uricase som konverterer urinsyre til allantoin. De fleste dyr har derfor et lavt urinsyrenivå, mens mennesket har et høyere nivå på ca. 386-416 mikromol/L. Dette fører til at serumurinsyrenivået, som er endeproduktet i purinmetabolismen raskere når sin fysiologiske grense for løselighet. Overskrides denne grensen, dannes det uratkrystaller. Krystalliseringen finner hyppigst sted i ledd, sener og bursae, men kan forekomme i de fleste vev og organer. Urinsyregikt affiserer minst 1% av populasjonen i vestlige land. Hyppigheten antas å vaere økende og er trolig den vanligste årsaken til inflammatorisk leddsykdom hos menn eldre enn 40 år (1).

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The epidemiology of hyperuricaemia and gout in Taiwan aborigines

Cited by 68 publications

References 0 publications

High prevalence of gouty arthritis among the Hmong population in Minnesota

High prevalence of gouty arthritis among the Hmong population in Minnesota

Hyperuricemia and Urologic Disease

Epidemiologi av urinsyregikt

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