The epidemiology of drug-resistant malaria

Björkman, Anders; Phillips-Howard, Penelope A.

doi:10.1016/0035-9203(90)90246-b

Cited by 137 publications

(64 citation statements)

References 41 publications

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“…Therefore, in the mid-to late 1960s, the antifolate combination of pyrimethamine/sulfadoxine was officially introduced, initially in Thailand, since chloroquineresistant P. falciparum had become prevalent in this area. However, resistance to pyrimethamine/sulfadoxine emerged soon after the official introduction (66,67), and this resistance subsequently spread to other regions in Southeast Asia (2).…”

Section: -3 Sulfadoxinementioning

confidence: 99%

Evolution of Plasmodium falciparum drug resistance: implications for the development and containment of artemisinin resistance

Mita¹,

Tanabe²

2012

Jpn J Infect Dis

100

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Section: -3 Sulfadoxinementioning

confidence: 99%

Evolution of Plasmodium falciparum drug resistance: implications for the development and containment of artemisinin resistance

Mita¹,

Tanabe²

2012

Jpn J Infect Dis

100

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“…1 However, the emergence and spread of Plasmodium falciparum resistant to chloroquine in almost all of sub-Saharan Africa has created an urgent need for additional, effective as well as sustainable control strategies. 2,3 The rediscovery 4 of impregnating mosquito nets with insecticides opened up the possibility of exploring a malaria control strategy with potential for community-based implementation.…”

mentioning

confidence: 99%

A controlled trial of lambda-cyhalothrin-impregnated bed nets and/or dapsone/pyrimethamine for malaria control in Sierra Leone.

Marbiah

Petersen²,

Koffi³

et al. 1998

The American Journal of Tropical Medicine and Hygiene

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Abstract. A randomized controlled trial investigated the impact of community-wide use of mosquito nets impregnated with lambda-cyhalothrin alone or with dapsone/pyrimethamine (d/p) prophylaxis on clinical malaria due to perennially transmitted Plasmodium falciparum in children in the Bo district of Sierra Leone. The 17 study communities were pair-matched and randomly allocated to receive treated mosquito nets or no nets and the children (age range ϭ 3 months-6 years) in each community were randomly allocated to receive d/p or placebo individually every two weeks. This resulted in each of the approximately 2,000 children recruited being in one of four study groups (impregnated mosquito nets and d/p prophylaxis, impregnated mosquito nets, d/p prophylaxis, and controls). The intervention phase of the study lasted 12 months. A total of 1,800 children attended more than 25% of the 48 total weekly morbidity surveillance surveys and were included in the analysis.

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“…8 Resistance of P. falciparum to pyrimethamine is widespread but shows distinct differences in geographical pattern and degree. 9 This resistance is associated with a point mutation at codon 108 of the parasite's dihydrofolate reductase (DHFR) gene leading to a substitution of serine by asparagine (Ser-108→Asn-108). Further mutations, i.e., Asn51→Ile-51 and Cys-59→Arg-59, increase the degree of resistance.…”

Section: Introductionmentioning

confidence: 99%

Plasmodium falciparum dihydrofolate reductase alleles and pyrimethamine use in pregnant Ghanaian women.

Mockenhaupt¹,

Eggelte²,

Böhme³

et al. 2001

The American Journal of Tropical Medicine and Hygiene

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Abstract. Drug resistance in Plasmodium falciparum affects prevention of malaria in pregnancy. In a crosssectional study of 530 pregnant Ghanaian women, P. falciparum dihydrofolate reductase (DHFR) gene mutations linked with pyrimethamine resistance were assessed and associations with pyrimethamine intake were analyzed. P. falciparum infected 69% of women without pyrimethamine use, 59% of those who had a history of pyrimethamine consumption but a negative urine test, and 53% of individuals with a positive urine test. Eighty-one percent, 43%, and 74% of the isolates contained the mutations Asn-108, Ile-51, and Arg-59, respectively. Thr-108 occurred in 8%. Pyrimethamine use was associated with increased frequencies of Asn-108 and Arg-59 but not of Ile-51 or Thr-108. In women with prophylaxis, wild-type parasites were absent and anemia tended to be more common with an increasing number of DHFR gene mutations. Pyrimethamine appears to be not adequately effective in this part of Ghana, most likely due to the predominance of resistant parasites. Selection for resistance following insufficient prophylaxis could possibly affect the efficacy of future intermittent sulfadoxine-pyrimethamine treatment.

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The epidemiology of drug-resistant malaria

Cited by 137 publications

References 41 publications

Evolution of Plasmodium falciparum drug resistance: implications for the development and containment of artemisinin resistance

Evolution of Plasmodium falciparum drug resistance: implications for the development and containment of artemisinin resistance

A controlled trial of lambda-cyhalothrin-impregnated bed nets and/or dapsone/pyrimethamine for malaria control in Sierra Leone.

Plasmodium falciparum dihydrofolate reductase alleles and pyrimethamine use in pregnant Ghanaian women.

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