The Epidemiology of Chronic Venous Diseases

Adhikari, A.; Criqui, Michael H.; Wooll, V.; Denenberg, Julie O.; Froněk, Arnošt; Langer, Róbert; Klauber, M.

doi:10.1007/s005230070031

Cited by 25 publications

(15 citation statements)

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“…Chronic leg ulceration affects 1–2 per cent of the population1, 2 and is associated with poor healing, frequent ulcer recurrence and significant morbidity3, 4. Venous reflux can be identified in more than 70 per cent of ulcerated legs5, 6, with multiple aetiologies.…”

Section: Introductionmentioning

confidence: 99%

Management of mixed arterial and venous leg ulcers

Humphreys

Stewart

Gohel

et al. 2007

British Journal of Surgery

102

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Section: Introductionmentioning

confidence: 99%

Management of mixed arterial and venous leg ulcers

Humphreys

Stewart

Gohel

et al. 2007

British Journal of Surgery

102

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“…CVI is characterized by intraluminal venous hypertension with blood stagnation and venous reflux. The exact mechanisms by which varicosis occurs are still unclear although several risk factors are known to be involved, including genetic predispositions, increasing age, obesity, physical activity, standing occupations, multiple pregnancies and connective tissue abnormalities [1,2,3]. …”

Section: Introductionmentioning

confidence: 99%

Identification of Differentially Expressed Genes in Human Varicose Veins: Involvement of Matrix Gla Protein in Extracellular Matrix Remodeling

et al. 2007

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This study was designed to identify the global pattern of differentially expressed genes in human varicose veins. Using suppressive subtractive hybridization, we identified overexpression of genes known to be associated with extracellular matrix remodeling, including collagen III, tissue inhibitor of metalloproteinases I, dermatopontin, matrix Gla protein (MGP) and tenascin C. Real-time polymerase chain reaction analysis confirmed the differential expression of these genes. The overexpression of MGP transcript was associated with increased MGP level in varicose veins, in particular the undercarboxylated form of the protein. Smooth muscle cells from varicose veins showed increased proliferation rate and enhanced matrix mineralization. This observation correlated with the presence of ectopic mineralization areas in the varicose vein walls. The use of warfarin, to inhibit MGP activity, or siRNA targeting MGP transcript induced a reduction in the exacerbated proliferation of varicose vein smooth muscle cells. Our results suggest that high expression of MGP in varicose veins may contribute to venous wall remodeling by affecting proliferation and mineralization processes probably through impaired carboxylation of MGP. In addition, suppressive subtractive hybridization results also produce a profile of differentially expressed genes in varicose veins, in particular extracellular matrix components. Further study of these genes will provide insights into their specific roles in the etiology of venous disease.

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“…20 Factors such as weight gain and a sedentary occupation which contributes to increased intra-abdominal pressure and negatively affects venous return to the heart should be checked. 21 Along with varicose veins, brownish discolouration, oedema, lower leg dryness, signs of increased skin folds in the lower part of the limb and Stemmer's sign (a thickened skin fold at the base of the second toe) should be checked to exclude preexisting lymphatic insufficiency. 22 Management of venous ulcers Following a proper clinical evaluation, identification of several clinical problems needs to be addressed to promote healing.…”

Section: Venous Ulcersmentioning

confidence: 99%

Chronic wounds and their management and application in a contemporary Sri Lankan hospital setting

Wadinamby¹

2013

Sri Lankan J Infec Dis

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The pathogenesis of chronic wounds is complex, resulting in major difficulties in the management of such wounds. Diabetes mellitus, venous ulceration and pressure sores contribute to the rapidly increasing burden of chronic wounds, not only to the patient but also to the health care system. Improved understanding of the factors which contribute to non healing of wounds and application of appropriate management modalities, including a multidisciplinary team approach, would help reduce the time for healing of such wounds. Colonization and infection of chronic wounds is only one component of the pathogenesis which however requires access to a modern microbiology laboratory. The setting up of chronic wound clinics in 3 hospitals in Sri Lanka may provide a model for improving the outcome of such wounds in a relatively under resourced setting.

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The Epidemiology of Chronic Venous Diseases

Cited by 25 publications

References 0 publications

Management of mixed arterial and venous leg ulcers

Management of mixed arterial and venous leg ulcers

Identification of Differentially Expressed Genes in Human Varicose Veins: Involvement of Matrix Gla Protein in Extracellular Matrix Remodeling

Chronic wounds and their management and application in a contemporary Sri Lankan hospital setting

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