The epidemiology of chronic syndromes that are frequently unexplained: do they have common associated factors?

Aggarwal, Vishal R.; McBeth, John; Zakrzewska, Joanna M; Lunt, Mark; Macfarlane, Gary J.

doi:10.1093/ije/dyi265

Cited by 297 publications

(220 citation statements)

References 33 publications

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“…Although there are more females (66%) than males (34%) in the UK general population with COFP symptoms (20), our sample was disproportionately female (just over 93% of participants).…”

Section: Sample Characteristicsmentioning

confidence: 87%

'I just wanted someone to tell me it wasn't all in my mind and do something for me': Qualitative exploration of acceptability of a CBT based intervention to manage chronic orofacial pain

et al. 2016

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“…Although there are more females (66%) than males (34%) in the UK general population with COFP symptoms (20), our sample was disproportionately female (just over 93% of participants).…”

Section: Sample Characteristicsmentioning

confidence: 87%

'I just wanted someone to tell me it wasn't all in my mind and do something for me': Qualitative exploration of acceptability of a CBT based intervention to manage chronic orofacial pain

et al. 2016

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“…Future research could also account for additional chronic pain conditions. Some conditions, such as chronic widespread pain, have been linked to adversity exposure and may possess overlapping characteristics with other conditions [1,19].…”

Section: Discussionmentioning

confidence: 99%

Lifetime exposure to adversity predicts functional impairment and healthcare utilization among individuals with chronic back pain

Seery

Leo

Holman

et al. 2010

Pain

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a b s t r a c tPrevious research has demonstrated an association between lifetime exposure to adverse events and chronic back pain (CBP), but the nature of this relationship has not been fully specified. Adversity exposure typically predicts undesirable outcomes, suggesting that lack of all adversity is optimal. However, we hypothesized that among individuals faced with CBP, a history of a low level of lifetime adversity would yield protective effects, manifested as lower impairment and healthcare utilization. Adult members of a national panel (N = 396) endorsed a history of CBP when reporting their physical health status in an online survey; they further reported their functional impairment and healthcare utilization. Respondents had previously completed a survey of lifetime exposure to adverse events. Significant Ushaped quadratic relationships emerged between adversity and self-rated functional impairment (p < 0.001), disabled employment status (p < 0.001), frequency of physician/clinic visits for CBP (p < 0.01), prescription (but not over-the-counter) analgesic use (p < 0.01), and comorbid depression treatment seeking (p < 0.01). Specifically, people with some lifetime adversity reported less impairment and healthcare utilization than people who had experienced either no adversity or a high level of adversity. Additional analyses failed to support alternative explanations of the findings. Implications for understanding and promoting resilience in the context of CBP are discussed. Ó

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“…The prevalence of chronic widespread pain was 5.2% [44]. In another population-based cross-sectional survey that included 2299 subjects, 15% reported chronic widespread pain, and 8% reported chronic fatigue [45]. Insomnia is also common, and can be associated with anxiety, depression and pain [46].…”

Section: The Possible Causes Of Post-lyme Disease Symptomsmentioning

confidence: 99%

Chronic Lyme Disease: A Review

Marques

2008

Infectious Disease Clinics of North America

167

123

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The epidemiology of chronic syndromes that are frequently unexplained: do they have common associated factors?

Abstract: This study has shown that chronic syndromes that are frequently unexplained co-occur in the general population and share common associated factors. Primary care practitioners need to be aware of these characteristics so that management is appropriate at the outset.

Cited by 297 publications

References 33 publications

'I just wanted someone to tell me it wasn't all in my mind and do something for me': Qualitative exploration of acceptability of a CBT based intervention to manage chronic orofacial pain

'I just wanted someone to tell me it wasn't all in my mind and do something for me': Qualitative exploration of acceptability of a CBT based intervention to manage chronic orofacial pain

Lifetime exposure to adversity predicts functional impairment and healthcare utilization among individuals with chronic back pain

Chronic Lyme Disease: A Review

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