The Epidemiology of Anal Human Papillomavirus and Related Neoplasia

Palefsky, Joel M.; Rubin, Mary

doi:10.1016/j.ogc.2009.02.003

Cited by 128 publications

(123 citation statements)

References 42 publications

Supporting

Mentioning

110

Contrasting

Unclassified

Order By: Relevance

“…35,36 Others, however, have calculated the current progression rate to be slower (0.3% per year). 30 An Ontario study looking at the costeffectiveness of detecting AIN 2/3 in men with HIV who have sex with men concluded that direct use of high-resolution anoscopy without preceding cytology was the best strategy. Although this approach was initially more costly, the expense was offset by a higher sensitivity and the low specificity of both HPV and cytology testing.…”

Section: Reviewmentioning

confidence: 99%

Anal cancer and intraepithelial neoplasia: epidemiology, screening and prevention of a sexually transmitted disease

Medford

Salit

2014

CMAJ

View full text Add to dashboard Cite

Section: Reviewmentioning

confidence: 99%

Anal cancer and intraepithelial neoplasia: epidemiology, screening and prevention of a sexually transmitted disease

Medford

Salit

2014

CMAJ

View full text Add to dashboard Cite

“…A possibilidade de detecção das lesões precursoras indica que programas padronizados de rastreamento para a prevenção do câncer anal e protocolos de tratamento para NIA, em doentes de risco, deveriam ser instituídos 12,13 . Os esfregaços anais para citologia vêm sendo realizados [9][10][11]14,15 , com eficácia semelhante à das coletas cervicais 16 , e com sensibilidade oscilando entre 42 e 98% e especificidade variando de 38 a 96%, quando os resultados foram comparados com os da histologia 10,16,17 .…”

Section: Rev Bras Coloproct Janeiro/março 2011unclassified

Evolução dos doentes com citologia oncótica alterada e colposcopia anal normal

Nadal¹,

Calore²,

Manzione³

et al. 2011

Rev bras. colo-proctol.

View full text Add to dashboard Cite

NADAL SR, CALORE EE, MANZIONE TS, MACHADO SP, MANZIONE CR, SEID VE, HORTA SHC. Evolução dos doentes com Evolução dos doentes com citologia oncótica alterada e colposcopia anal normalOutcome of patients with anal oncotic cytology alterations and normal anal colposcopy INTRODUÇÃOO papilomavírus humano (HPV) é o mais comum dos agentes etiológicos sexualmente transmissíveis, provocando doenças na região perianal 1 . Embora a maioria das infecções pelo HPV não apresente manifestação clínica, 10% dos doentes desenvolverão verrugas, papilomas ou displasias 2 . Além disso, é descrita a possibilidade de progressão das displasias, ou neoplasias intraepiteliais anais (NIA), para carcinoma invasivo 3 , e a maioria ocorreria na zona de transição do canal anal 4 .Outra característica das lesões HPV induzidas é a elevada incidência de recidivas. Revisando a literatu-

show abstract

“…Persistent infection with high-risk types of human papillomavirus (HR-HPV) is responsible for >80% of cases. SCC mainly affects women over the age of 50 years; among men, SCC predominantly affects individuals in the age range of 20 to 49 years [3]. There are few epidemiological data for anal human papillomavirus (HPV) infection in Brazil.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of human papillomavirus infection in squamous cell carcinoma of the anal canal in a Northeast City in Brazil: viral genotyping and clinical aspects

et al. 2017

View full text Add to dashboard Cite

Background: Anal cancer malignancies comprise about 1.5 to 3% of cancers from the gastrointestinal in which high-risk types of human papillomavirus (HR-HPV) is responsible for >80% of cases. The aim of this work was to detect and perform human papillomavirus (HPV) genotyping in squamous cell carcinoma specimens from the anal canal and to investigate the association between viral infection and histopathological and clinical aspects. Methods: The presence of genotype-specific HPV DNA in formalin-fixed paraffin embedded tissue from 27 anal SCC samples from a reference cancer hospital of São Luís, State of Maranhão, Brazil was performed by Linear Array HPV Genotyping Test and the INNO-LiPA HPV Genotyping Assay. Fisher's Exact test and Chi-square test were performed in order to evaluate the association between HPV type and clinical and morphological variables. P values less than 0.05 were considered statistically significant. Results: Average age of patients at the time of diagnosis was 54.96 years ± 15.81; 74.07% of patients were female. Vegetative ulcers represented the most common type of lesion (22.22%). The lesions ranged in size from 2.1 cm to 5.0 cm and mostly were well-differentiated (70.38%). Lymph node involvement was observed in 26% of the patients. Molecular evaluation revealed that HPV infection was detected in 81.48% of the lesions, and the most common type found was the oncogenic HPV 16. Statistical analysis indicated that the clinical and histopathological variables were not associated with HPV infection. Conclusions: Our results indicate that anal SCC rarely occurs in the absence of HPV and emphasize the predominant role of HPV16. The evaluation about genotype-specific prevalence of HPV in anal SCC is important to assess the potential benefit of HPV vaccination.

show abstract

The Epidemiology of Anal Human Papillomavirus and Related Neoplasia

Cited by 128 publications

References 42 publications

Anal cancer and intraepithelial neoplasia: epidemiology, screening and prevention of a sexually transmitted disease

Anal cancer and intraepithelial neoplasia: epidemiology, screening and prevention of a sexually transmitted disease

Evolução dos doentes com citologia oncótica alterada e colposcopia anal normal

Prevalence of human papillomavirus infection in squamous cell carcinoma of the anal canal in a Northeast City in Brazil: viral genotyping and clinical aspects

Contact Info

Product

Resources

About