The epidemiology of acute coronary syndromes in French Guiana

Rochemont, Devi; Lemenager, P.; Franck, Y.; Farhasmane, A.; Sabbah, Nadia

doi:10.1016/j.ancard.2020.09.032

Cited by 9 publications

(6 citation statements)

References 9 publications

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“…In French Guiana, over half of the population lives under the poverty level. It is well known that, for infectious or non-communicable diseases, the most deprived patients consult later, with more severe presentations at a younger age [4,[25][26][27]. For breast cancer survival, for instance, we have shown that crude survival was lower than in mainland France but that, when only considering French-Guiana-born women, there was no longer any difference with mainland France.…”

Section: Discussionmentioning

confidence: 66%

The Epidemiologic Transition in French Guiana: Secular Trends and Setbacks, and Comparisons with Continental France and South American Countries

et al. 2023

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There are great variations between population subgroups, notably in poorer countries, leading to substantial inconsistencies with those predicted by the classical epidemiologic transition theory. In this context, using public data, we aimed to determine how the singular case of French Guiana fit and transitioned in the epidemiologic transition framework. The data show a gradual decline in infant mortality to values above 8 per 1000 live births. Premature mortality rates were greater but declined more rapidly in French Guiana than in mainland France until 2017 when they reascended in a context of political turmoil followed by the COVID-19 pandemic and strong reluctance to get vaccinated. Although infections were a more frequent cause of death in French Guiana, there is a marked decline and circulatory and metabolic causes are major causes of premature death. Fertility rates remain high (>3 live births per woman), and the age structure of the population is still pyramid-shaped. The singularities of French Guiana (rich country, universal health system, widespread poverty) explain why its transition does not fit neatly within the usual stages of transition. Beyond gradual improvements in secular trends, the data also suggest that political turmoil and fake news may have detrimentally affected mortality in French Guiana and reversed improving trends.

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Section: Discussionmentioning

confidence: 66%

The Epidemiologic Transition in French Guiana: Secular Trends and Setbacks, and Comparisons with Continental France and South American Countries

et al. 2023

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“…Thus, in 2015, 82% of “undocumented” people who had arrived for more than 3 months were not covered by the Aide Médicale Etat health insurance (health insurance for undocumented foreigners) despite being eligible for it ( 63 ). As a general rule of thumb, for infectious, chronic, obstetrical, or nutritional diseases, immigrants tend to have more advanced pathologies, which occur at younger ages ( 60 , 64–69 ). However, for prolonged diseases, once immigrants benefit from health insurance, the differences between foreign and French or between precarious and non-precarious persons tend to disappear because the health system strives to compensate for their vulnerabilities by enhancing therapeutic education, health mediation and translation services, nurse visits at home ( 62 ), and an increased tendency to hospitalize patients living in difficult conditions ( 61 ).…”

Section: Resultsmentioning

confidence: 99%

Contrasted life trajectories: reconstituting the main population exposomes in French Guiana

Nacher,

Basurko,

Douine

et al. 2024

Front. Public Health

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In French Guiana, life expectancy is between 2 and 3 years below that of France, reflecting differences in mortality rates that are largely sensitive to primary healthcare and thus preventable. However, because poverty affects half of the population in French Guiana, global measurements of life expectancy presumably conflate at least two distinct situations: persons who have similar life expectancies as in mainland France and persons living in precariousness who have far greater mortality rates than their wealthier counterparts. We thus aimed to synthesize what is known about statistical regularities regarding exposures and sketch typical French Guiana exposomes in relation to health outcomes. We conducted a narrative review on common exposures in French Guiana and made comparisons between French Guiana and mainland France, between rich and poor in French Guiana, and between urban and rural areas within French Guiana. The most striking fact this panorama shows is that being a fetus or a young child in French Guiana is fraught with multiple threats. In French Guiana, poverty and poor pregnancy follow-up; renouncing healthcare; wide variety of infectious diseases; very high prevalence of food insecurity; psychosocial stress; micronutrient deficiencies; obesity and metabolic problems; and frequent exposure to lead and mercury in rural areas constitute a stunningly challenging exposome for a new human being to develop into. A substantial part of the population’s health is hence affected by poverty and its sources of nutrition.

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“…[ 6 ] Compared to non-ST-segment elevation myocardial infarction patients, STEMI patients have a higher short-term mortality rate and poorer long-term prognosis after PCI. [ 7 , 8 ] Therefore, comprehensive assessment and identification of STEMI patients at risk of poor prognosis are necessary for further intervention and care.…”

Section: Introductionmentioning

confidence: 99%

Serum ACSL4 levels in patients with ST-segment elevation myocardial infarction (STEMI) and its association with one-year major adverse cardiovascular events (MACE): A prospective cohort study

Hu,

Li,

Wang

2024

Medicine

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In the present prospective cohort research, we aimed to explore the serum levels of Acyl-CoA synthetase long-chain family member 4 (ACSL4) in patients with ST-segment elevation myocardial infarction (STEMI) and its association with 1-year major adverse cardiovascular events (MACE). This prospective cohort study recruited 507 patients who underwent percutaneous coronary intervention for the treatment of STEMI at our hospital during August 2019 to July 2022. The serum ACSL4, tumor necrosis factor-α, interleukin (IL)-6, IL-1β, and C-reactive protein levels were measured by enzyme-linked immunosorbent assay. Demographic and clinical statistics were also collected. In addition, all patients were followed up for 1 year, and patients with MACE were defined as poor prognosis group. All data used SPSS 26.0 to statistical analyses. The poor prognosis group had significantly higher age and low-density leptin cholesterol (LDLC) levels compared to the favorable prognosis group (P < .05). STEMI patients exhibited significantly elevated serum levels of ACSL4, tumor necrosis factor-α, IL-6, IL-1β, and C-reactive protein (P < .05). Serum ACSL4 and IL-1β levels in the poor prognosis group were remarkably enhanced compared to the favorable prognosis group. Curvilinear regression analysis demonstrated that ACSL4 was associated with LDLC and IL-1β. Moreover, ACSL4 (B = 0.138, 95% CI 1.108–1.189, P < .001), LDLC (B = 2.317, 95% CI 5.253–19.603, P < .001), and IL-1β (B = 0.061, 95%CI 1.008–1.122, P = .025) levels were the risk factors for STEMI patients with 1-year MACE. This study showed that the serum ACSL4 levels was remarkably elevated in STEMI patients. This study might provide new targets and a comprehensive approach to cardiovascular protection in STEMI patients.

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The epidemiology of acute coronary syndromes in French Guiana

Cited by 9 publications

References 9 publications

The Epidemiologic Transition in French Guiana: Secular Trends and Setbacks, and Comparisons with Continental France and South American Countries

The Epidemiologic Transition in French Guiana: Secular Trends and Setbacks, and Comparisons with Continental France and South American Countries

Contrasted life trajectories: reconstituting the main population exposomes in French Guiana

Serum ACSL4 levels in patients with ST-segment elevation myocardial infarction (STEMI) and its association with one-year major adverse cardiovascular events (MACE): A prospective cohort study

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