The epidemiology and management of odontogenic keratocysts (OKCs): A European multicenter study

Boffano, Paolo; Cavarra, Francesco; Agnone, Anna Maria; Brucoli, Matteo; Ruslin, Muhammad; Forouzanfar, Tymour; Ridwan-Pramana, Angela; Rodríguez-Santamarta, Tanía; Vicente, Juan Carlos de; Starch‐Jensen, Thomas; Pechalova, Petia; Павлов, Н. В.; Doykova, Iva; Gospodinov, Dimitar; Konstantinović, Vitomir S.; Jovanović, Milan B.; Barrabé, Aude; Louvrier, Aurélien; Meyer, Christophe; Tamme, Tiia; Андрианов, А. Ю.; Dovšak, Tadej; Birk, Anže; Masu, Lavinia; Rocchetti, Vincenzo

doi:10.1016/j.jcms.2021.09.022

Cited by 19 publications

(13 citation statements)

References 22 publications

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“…3 Studies show that Ki-67 and p53 reveal intense positivity in OKC as compared to other OCs. 5 Clinicopathological features (age, gender, site, ragiographic presentation and histology) are important parameters of OCs yet Ki-67 depict potential transformation of OCs into neoplasia. 5,6 Expression of Ki-67 was variable in OKC as reported by many authors, however few foci expressed higher expression of Ki-67.…”

Section: Original Articlementioning

confidence: 99%

“…5 Clinicopathological features (age, gender, site, ragiographic presentation and histology) are important parameters of OCs yet Ki-67 depict potential transformation of OCs into neoplasia. 5,6 Expression of Ki-67 was variable in OKC as reported by many authors, however few foci expressed higher expression of Ki-67. 7 Orthokeratinized odontogenic cyst (OOC) revealed low expression of Ki-67 as compared to OKC.…”

Section: Original Articlementioning

confidence: 99%

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Clinicopathological Features and Expression of Ki-67 in Odontogenic Keratocyst, Dentigerous Cyst and Radicular Cyst

Rasul

Saif

Jehangir³

et al. 2023

J Islamabad Med Dental Coll

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Background: Biological behaviour of Odontogenic Keratocyst (OKC) is aggressiveness than others Odontogenic Cysts (OCs) like Dentigerous Cyst (DCs) and Periapical Cyst/Residual Cysts (RCs). The aim of the study was to determine clinicopathological features and expression of Ki-67 in Odontogenic Cysts of the oral cavity. Methodology: This cross-sectional study was conducted at de’Montmorency College of Dentistry (DCD from Feb, 2020 to Feb, 2022 after approval from Institutional Review Board (IRB) of DCD. A total 78 cases of OCs were collected from hospitals which are affiliated with the DCD. Routine lab process for Hematoxylin & Eosin and Immunohistochemistry was performed. Data entry and statistical analysis was carried out in SPSS 21. A Chi- square test was applied to observe the association between cyst and Ki-67. P value < 0.05 was taken as statistically significant. Results: Among total 78 cases the mean age was 25.08 ±14.5 years with an age range of 6-70 years. Most OCs (64.1%) were reported in males than females (35.89%). Most OCs were reported in mandible (56.4%. Ki-67 expression in OKC was high 7.7%, low in 76.9% and negative in 15.4%). Most of the DCs and RCs expressed low expression of Ki-67 (84.6% and 76.9% respectively). Conclusion: Most of the odontogenic cysts expressed low expression of Ki-67 while few cases of OKC and DC expressed high expression. Keywords: Dentigerous Cyst, Odontogenic Keratocyst, Immunohistochemistry, Ki-67, Odontogenic Cysts, Periapical Cyst, Radicular Cyst.

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Section: Original Articlementioning

confidence: 99%

Section: Original Articlementioning

confidence: 99%

Clinicopathological Features and Expression of Ki-67 in Odontogenic Keratocyst, Dentigerous Cyst and Radicular Cyst

Rasul

Saif

Jehangir³

et al. 2023

J Islamabad Med Dental Coll

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“…1 These cysts can be developmental or inflammatory and include diverse pathologies such as odontogenic keratocysts (OKCs), dentigerous cysts, and radicular cysts among others. [2][3][4] The standard of care has been transoral excision with extraction of involved teeth. However, for large cysts, a transoral-only approach limits access to the entire lesion and requires greater bony exposure, with the potential for incomplete excision.…”

Section: Introductionmentioning

confidence: 99%

“…Odontogenic cysts are fluid‐filled, epithelial‐lined cavities of dental origin with the potential to damage adjacent dentition and maxillary sinus with associated sinonasal symptomatology 1 . These cysts can be developmental or inflammatory and include diverse pathologies such as odontogenic keratocysts (OKCs), dentigerous cysts, and radicular cysts among others 2–4 . The standard of care has been transoral excision with extraction of involved teeth.…”

Section: Introductionmentioning

confidence: 99%

Combined Transnasal, Transoral Excision of Odontogenic Cysts Offers Reduced Recurrence Rates and Favorable Sinonasal Outcomes

Douglas,

Wei,

Panara

et al. 2024

The Laryngoscope

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“…This disease usually involve mandible. In Mandible, the third molar area and the ascending ramus are the more common site of involvement 4 . Maxillary lesions causes more morbidity.…”

Section: Introductionmentioning

confidence: 99%

Clinical and Radiologic Spectrum of Odontogenic Keratocyst: Descriptive Study

Khan¹,

Alamgir²,

Jadoon³

et al. 2023

PJMHS

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Background: Odontogenic keratocyst is relatively common developmental odontogenic lesion occurring with a frequency of approximately 10-14% of all jaw cyst. Aim: To find the clinic-radiologic pattern of odontogenic keratocyst cases. Study design: Descriptive cross sectional. Methodology: Present study was conducted at Pathology and diagnostic Medicine, Khyber Medical University Peshawar in which 83 patients were enrolled. An OPG x-ray was done for all the patients to see the nature of the lesion. Surgical specimens were stored in formalin solution. After gross examination, they were evaluated histopathologically for diagnosis of Odontogenic keratocyst according to WHO criteria2. Data was collected through performa by non-probability convenient sampling following ethical approval. Data was evaluated by using SPSS version 23. Quantitative data was presented as mean ± SD. Categorical data was presented by frequency and percentage. Chi square was applied with p-value <0.05 as significant. Results: Almost 55.4% were male patients. Almost 45.8% patients were in the 4th decade of their life. The mandible was the most common site of involvement accounting for 68.7%. An impacted tooth was associated in 26.5% of cases. Conclusion: It was concluded that OKC involved mandible while occurring in 4th decade of life among males commonly. There was an association with an impacted tooth, therefore to rule out the presence of odontogenic keratocyst, all impacted teeth should be assessed. Key words: Impacted Tooth, Multilocular, Odontogenic Keratocyst and Satellite Cyst.

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The epidemiology and management of odontogenic keratocysts (OKCs): A European multicenter study

Cited by 19 publications

References 22 publications

Clinicopathological Features and Expression of Ki-67 in Odontogenic Keratocyst, Dentigerous Cyst and Radicular Cyst

Clinicopathological Features and Expression of Ki-67 in Odontogenic Keratocyst, Dentigerous Cyst and Radicular Cyst

Combined Transnasal, Transoral Excision of Odontogenic Cysts Offers Reduced Recurrence Rates and Favorable Sinonasal Outcomes

Clinical and Radiologic Spectrum of Odontogenic Keratocyst: Descriptive Study

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