The epidemiology and management of ameloblastomas: A European multicenter study

Boffano, Paolo; Cavarra, Francesco; Tricarico, Gerardo; Masu, Lavinia; Brucoli, Matteo; Ruslin, Muhammad; Forouzanfar, Tymour; Ridwan-Pramana, Angela; Rodríguez-Santamarta, Tanía; M, Ranz; Vicente, Juan Carlos de; Jensen, Thomas Starch; Pechalova, Petia; Павлов, Н. В.; Doykova, Iva; Konstantinović, Vitomir S.; Jelovac, Drago; Barrabé, Aude; Louvrier, Aurélien; Meyer, Christophe; Tamme, Tiia; Андрианов, А. Ю.; Dovšak, Tadej; Birk, Anže; Hresko, Andrii; Chepurnyi, Yurii; Копчак, Андрій; Snäll, Johanna; Hagström, Jaana; Rasmusson, Lars; Rocchetti, Vincenzo

doi:10.1016/j.jcms.2021.09.007

Cited by 21 publications

(20 citation statements)

References 8 publications

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“…The growth of ameloblastoma occurs in the buccolingual direction, resulting in significant expansion. The mean size of ameloblastomas at presentation is approximately 4 cm [24]. Pain is an uncommon symptom of ameloblastoma but can occur because of hemorrhage inside or adjacent to the tumor.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…After treatment, ameloblastoma may recur with an overall recurrence rate of 9.8% according to a Chinese study [32] and 19.3% as per a European multicenter study [24]. Recurrence rates are dictated by the type of surgery used (radical versus conservative), the adequacy of the surgical margins, and in cases of maxillary ameloblastoma extension into vital structures such as the orbit, paranasal sinuses, or skull base.…”

Section: Prognosismentioning

confidence: 99%

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Ameloblastoma: An Updated Narrative Review of an Enigmatic Tumor

Ghai¹

2022

Cureus

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Ameloblastoma is one of the most common benign odontogenic tumors of the jaw that constitutes about 10% of all tumors that arise in the mandible and maxilla. It is a slow-growing but locally invasive tumor that presents with painless swelling of the mandible or maxilla. The World Health Organization (WHO) classification of 2017 describes ameloblastomas of the following four types: ameloblastoma; unicystic ameloblastoma; extraosseous/peripheral ameloblastoma; and metastasizing ameloblastoma. The diagnosis of ameloblastoma requires computerized tomography (CT) imaging as well as a biopsy. A biopsy is helpful in differentiating ameloblastoma from ossifying fibroma, osteomyelitis, giant cell tumor, cystic fibrous dysplasia, myeloma, and sarcoma. The best treatment of ameloblastoma is aggressive en bloc resection with simultaneous reconstruction. The high recurrence rate and large tissue defects have been long-standing issues in the treatment of ameloblastoma. Recent molecular developments strongly suggest the possibility of targeted therapy with better outcomes in ameloblastomas. We present a detailed updated narrative review of our current understanding and management of this enigmatic tumor.

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Section: Clinical Presentationmentioning

confidence: 99%

Section: Prognosismentioning

confidence: 99%

Ameloblastoma: An Updated Narrative Review of an Enigmatic Tumor

Ghai¹

2022

Cureus

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“…11,18 A peak incidence in the third decade was noted for African and South American patients, compared to a peak in the fifth and sixth decades for a North American and European population. 8,17 The cause of these varying demographic figures has been speculated to be related to different aetiological agents or poor nutrition. 8 ABs have varying sex predilections in different population groups, with no outright strong sex predominance.…”

Section: Discussionmentioning

confidence: 99%

“…1,14 ABs can be treated conservatively or via resection, depending on the clinical features and histopathologic classification. [15][16][17] Reichart et al reported that patients with ABs in developing countries typically present for treatment at a later stage (33 months) compared to developed countries (25 months). 11 Due to their longer duration in developing countries, ABs may present as extensive lesions with unique presentations.…”

Section: Introductionmentioning

confidence: 99%

Clinicoradiologic features of ameloblastomas: A single‐centre study of 155 cases

Smit,

Robinson,

Ker‐Fox

et al. 2024

J Oral Pathology Medicine

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BackgroundThe purpose of the current study was to report on the clinical presentation and radiologic features of 155 cases of ameloblastoma (AB), representing a detailed, large, single‐centre radiologic study.MethodsHistologically confirmed cases were reviewed over 11 years. Demographic and clinical data were retrieved from the patient's records. Radiologic information was analysed from available radiographs. The radiologic features of ABs were assessed according to the mean age of presentation and the mean duration of the lesion. The distinguishing radiologic features between adults/children and sex were also evaluated.ResultsA statistically significant correlation existed between loss of border demarcation and advanced mean age. Multilocular lesions were markedly more common in adults compared to children. Multilocular ABs were associated with increased lesion duration and advanced mean age. Radiologic signs of reactive bony changes associated with the tumour presented at the highest mean duration of all bony effects. Bony expansion and cortical destruction were statistically correlated with lesion duration. Tooth impaction was more common in children. Some mandibular lesions reached a significant size, resulting in impingement of the maxillary sinus, zygoma, orbit and pterygoid plates.ConclusionDue to unfortunate healthcare access constraints, ABs grow to significant sizes and exhibit features not often reported in the literature. The findings of this analysis highlighted the radiologic features of ABs expressed through the mean age and duration of the lesion. This emphasises the significance of timely management of these lesions.

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“…Ameloblastoma is characterized by a high recurrence rate related to surgical treatment strategy, indeed incidence of recurrence ranges from 55% to 90% following conservative treatment, significantly higher than the incidence rate of 15–25% following more radical treatment. However radical treatment strategy is associated with a significantly higher risk of post-surgical complications, a lower rate of prosthetic rehabilitation, and serious aesthetic and functional impairment [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Mandibular Reconstruction after Resection of Ameloblastoma by Custom-Made CAD/CAM Mandibular Titanium Prosthesis: Two Case Reports, Finite Element Analysis and Discussion of the Technique

et al. 2023

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Virtual surgical planning for CAD/CAM mandibular reconstruction by titanium prosthesis was recently reported for resected cases. Even if some advantages are evident, difficulties that may arise for TMJ function after reconstruction originate from prosthesis contamination through oral mucosa dehiscence. In these two cases reported of mandibular reconstruction after resection of ameloblastoma by custom-made CAD/CAM titanium prosthesis, the procedures were aimed to preserve the TMJ glenoid cavity and articular disc avoiding functional problems for hemi-mandibular resections that included the condyle (as in case #1) or with condylar preservation (as in case #2) and avoiding intraoral incisions in both cases. The entire surgical planning and prosthetic fabrication were explained with specifications and the sequence of the surgical procedure. Finite elements analysis (FEA) was performed to check the force distribution and efficacy of the prosthetic device (case 1 with hemi-mandibular resection and rehabilitation). Although successful in these two cases, surgical reconstruction of the mandibular defect after resection by a CAD-CAM custom-made prosthesis still shows some drawbacks and failure risks. Several advantages of this technique and the surgical success in these two cases were presented, but limitations and side effects must be considered when cases are selected.

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The epidemiology and management of ameloblastomas: A European multicenter study

Cited by 21 publications

References 8 publications

Ameloblastoma: An Updated Narrative Review of an Enigmatic Tumor

Ameloblastoma: An Updated Narrative Review of an Enigmatic Tumor

Clinicoradiologic features of ameloblastomas: A single‐centre study of 155 cases

Mandibular Reconstruction after Resection of Ameloblastoma by Custom-Made CAD/CAM Mandibular Titanium Prosthesis: Two Case Reports, Finite Element Analysis and Discussion of the Technique

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