The Epidemiology and Geographic Distribution of Nontuberculous Mycobacteria Clinical Isolates from Sputum Samples in the Eastern Region of China

Shao, Yan; Chen, Cheng-Ann; Song, Hwangjun; Li, Guoli; Li, Qiao; Li, Yan Chun; Zhu, Limei; Martínez, Leonardo; Lü, Wei

doi:10.1371/journal.pntd.0003623

Cited by 49 publications

(36 citation statements)

References 30 publications

(35 reference statements)

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“…In many countries, MAC (including M. intracellulare and M. avium ) are the most common NTM isolates. On the other hand, M. avium is predominant in North- and South America, M. intracellulare is most frequently isolated in Australia-Queensland, South Africa and some provinces in China6202122. Our study showed that M. intracellulare was the most common species of NTM isolation, followed by M. abscessus in Beijing Chest Hospital which is located in north of China.…”

Section: Discussionmentioning

confidence: 58%

Clinical Significance of Nontuberculous Mycobacteria Isolated From Respiratory Specimens in a Chinese Tuberculosis Tertiary Care Center

Duan

Han

Wang

et al. 2016

Sci Rep

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The clinical relevance of non-tuberculous mycobacteria (NTM) has been reported to be different dramatically by species or by regions, however, no such evaluation has been performed in China.A retrospective study was performed in Beijing Chest Hospital. All the NTM strains isolated from respiratory specimens in the past 5 years, and patients’ clinical records (symptoms and radiographic information etc.) were investigated. The clinical relevance was evaluated according to the criteria recommended by the American Thoracic society. Totally 232 NTM strains were recruited, among them, M. intracellulare was the dominant species (40.5%), followed by M. abscessus (28.4%). 109 patients, with 185 total isolates, had full clinical records available for review. 84.4% (38/45), 85.7% (24/28%) and 63.6% (7/11) of patients with isolation of M. intracellulare, M. abscessus and M. kansasii, respectively, were categorized as definite NTM disease. Whereas all the 10 patients with isolation of M. gordonae were defined as unlikely NTM disease. The majority of NTMs isolates yielded from respiratory specimens in Beijing Chest Hospital were clinically significant, and M. intracellulare and M. abscessus was the dominated species of NTM lung disease. NTM lung infections demonstrated some specific chest radiograph characteristics.

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Section: Discussionmentioning

confidence: 58%

Clinical Significance of Nontuberculous Mycobacteria Isolated From Respiratory Specimens in a Chinese Tuberculosis Tertiary Care Center

Duan

Han

Wang

et al. 2016

Sci Rep

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“…Although disseminated NTM disease is seen almost exclusively in immunosuppressed individuals, the vast majority of pulmonary NTM disease in the United States is due to Mycobacterium avium complex (MAC) and occurs in seemingly immunocompetent patients, disproportionately affecting females, older persons, and those with bronchiectasis or chronic obstructive lung disease (2)(3)(4)(5)(6)(7). Incidence rates are between 5/100,000 (general population) and 30/100,000 (.80 years old) patient-years, and are on the rise (6).…”

mentioning

confidence: 99%

A Rhesus Macaque Model of Pulmonary Nontuberculous Mycobacterial Disease

Winthrop

Rivera

Engelmann

et al. 2016

Am J Respir Cell Mol Biol

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In this study, we sought to develop a nonhuman primate model of pulmonary Mycobacterium avium complex (MAC) disease. Blood and bronchoalveolar lavage fluid were collected from three female rhesus macaques infected intrabronchially with escalating doses of M. avium subsp. hominissuis. Immunity was determined by measuring cytokine levels, lymphocyte proliferation, and antigen-specific responses. Disease progression was monitored clinically and microbiologically with serial thoracic radiographs, computed tomography scans, and quantitative mycobacterial cultures. The animal subjected to the highest inoculum showed evidence of chronic pulmonary MAC disease. Therefore, rhesus macaques could provide a robust model in which to investigate host-pathogen interactions during MAC infection.

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“…In addition, our project site (Danyang county of Jiangsu province) is located close to the sea where nontuberculous Mycobacterium is highly prevalent. In prior work from our province, we have shown that the prevalence of nontuberculous Mycobacterium is high . This is likely also influential to the poor test concordance that we see in this study .…”

Section: Discussionmentioning

confidence: 47%

“…In prior work from our province, we have shown that the prevalence of nontuberculous Mycobacterium is high. 35 This is likely also influential to the poor test concordance that we see in this study. 36 Although our results show a relationship between diabetes and QFT positivity, the same association is not present with diabetes and tuberculin positivity.…”

Section: Discussionmentioning

confidence: 85%

Undiagnosed diabetes mellitus and tuberculosis infection: A population‐based, observational study from eastern China

Lü

Martínez

et al. 2020

Diabetes Metabolism Res

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Background China has the largest dual diabetes and tuberculosis epidemic globally. No studies from mainland China have assessed the relationship between tuberculosis infection and diabetes. We conducted a population‐based, observational study in eastern China to further explore this relationship. Methods A blood glucose, Quantiferon, and tuberculin skin test were administered at baseline. We compared tuberculosis infection in nondiabetics and diabetics. The cohort was additionally screened for tuberculosis progression over 5 years. Results Among 5405 participants, diabetics had elevated levels of Quantiferon and tuberculin positivity, largely driven by undiagnosed diabetics (compared with nondiabetics, adjusted odds ratios of 1.53; 95% confidence interval [CI], 1.05‐2.23 and 1.58; 95% CI, 1.07‐2.35 for tuberculin and Quantiferon positivity). During follow‐up, the annual tuberculosis incidence was three times higher for diabetics compared with the entire cohort. Conclusions These results suggest improving diabetic control through rapidly identifying undiagnosed diabetes may have indirect benefits to tuberculosis control. Targeting of preventive therapy to newly diagnosed diabetics at high‐risk for progressive tuberculosis in China should be considered.

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The Epidemiology and Geographic Distribution of Nontuberculous Mycobacteria Clinical Isolates from Sputum Samples in the Eastern Region of China

Cited by 49 publications

References 30 publications

Clinical Significance of Nontuberculous Mycobacteria Isolated From Respiratory Specimens in a Chinese Tuberculosis Tertiary Care Center

Clinical Significance of Nontuberculous Mycobacteria Isolated From Respiratory Specimens in a Chinese Tuberculosis Tertiary Care Center

A Rhesus Macaque Model of Pulmonary Nontuberculous Mycobacterial Disease

Undiagnosed diabetes mellitus and tuberculosis infection: A population‐based, observational study from eastern China

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