The epidemic situation of HIV infection in the Russian Federation in 2019

Ladnaia, Ladnaia N.N.; Pok­rovsky, Pok­rovsky V.V.; Dementyeva, Dementyeva L.A.; Sokolova, Sokolova E.V.; Well-Being, Moscow Human

doi:10.18565/epidem.2020.10.3.17-26

Cited by 8 publications

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“…1 LGV proctitis has been especially prevalent among HIVpositive MSM internationally. 11 In Russia, the number of people living with HIV recently exceeded 1.4 million, 12 suggesting that the MSM subpopulation may be at a high risk of having HIVas well as LGVand the prevalence of LGV in MSM might be underestimated. Suboptimal or lack of access to efficient healthcare in Russia for MSM may significantly contribute to the burden of LGV and other STIs.…”

Section: Introductionmentioning

confidence: 99%

First reported lymphogranuloma venereum cases in Russia discovered in men who have sex with men attending proctologists

et al. 2022

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Background Several lymphogranuloma venereum (LGV) outbreaks among men who have sex with men (MSM) have been reported throughout the world since 2003. Nevertheless, no LGV cases have been internationally reported from Russia. We evaluated the prevalence of LGV among MSM attending proctologists in Moscow, Russia, and compared the LGV and non-LGV rectal Chlamydia trachomatis (CT) infections. Methods MSM ( n = 534) attending for proctologic care were included. Rectal specimens were sampled for CT and Neisseria gonorrhoeae (NG) by nucleic acid amplification tests (NAATs). All CT-positive patients were tested with an LGV-specific NAAT. Results In total, 37.3% (95% CI 33.3–41.5; 199/534) of MSM were CT positive. Of these, 68.8% (95% CI 62.1–74.9; 137/199) had LGV and 31.2% (95% CI 25.1–37.9; 62/199) a non-LGV rectal CT infection. Older age (34 years vs. 31 years, p = 0.035) and group-sex practices (67.2% (92/137) vs. 33.9% (21/62), p < 0.0001) were associated with LGV. The LGV-positive MSM were also more likely to be HIV-positive (67.2% (92/137) vs. 41.9% (26/62), p = 0.001). Proctoscopy revealed ulcerative proctitis/proctocolitis in 99.3% (136/137) of LGV-positive MSM. No ulcerative or erosive proctitis was found in the MSM with non-LGV CT infection, but 58.1% (36/62) of them had anorectal disorders. Finally, mild catarrhal or hemorrhagic proctitis was diagnosed in only 21.6% (8/37) of MSM with non-LGV CT infection lacking concomitant NG or syphilis ( p < 0.0001). Conclusions LGV is widely spread among MSM attending proctologists in Moscow. Clinically, acute LGV proctitis/proctocolitis can be difficult to distinguish from inflammatory bowel disease that leads to mismanaged LGV infections. LGV diagnostic laboratory testing is essential, however, currently mainly lacking for MSM in Russia. All MSM with CT-positive rectal specimens should be subsequently tested for LGV.

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Section: Introductionmentioning

confidence: 99%

First reported lymphogranuloma venereum cases in Russia discovered in men who have sex with men attending proctologists

et al. 2022

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The predictive value indicators of first trimester biochemical screening in assessing unfavorable factors of pregnancy course in women with HIV as well as hepatitis B and C

Pseush

Zozulya

Mikhaleva

2022

Akušerstvo, ginekologiâ i reprodukciâ

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Aim: to find out the predictive value of blood serum biochemical parameters PAPP-A (pregnancy-associated plasma protein A) and β-hCG (beta subunit of human chorionic gonadotropin) in the assessment of unfavorable pregnancy outcomes in women infected by human immunodeficiency virus (HIV) as well as viral hepatitis B (HBV) and C (HCV).Materials and Methods. A retrospective study of the medical records from 52 women was carried out, including 19 HIV-infected women, 9 women with monoinfection HBV or HCV, 11 pregnant women who were co-infected (HIV/HBV or HIV/HCV) and 13 uninfected women. PAPP-A and β-hCG levels, expressed as MoM (multiple of median), were evaluated in all women.Results. Our study revealed that only PAPP-A was prognostically significant for developing chronic placental insufficiency in women with HIV infection and co-infection of HIV together hepatitis B and C. None of the parameters examined were significant in women with HBV or HCV monoinfection. PAPP-A and β-hCG in pregnant women without infections were effective in predicting development of chronic placental insufficiency.Conclusion. PAPP-A can be used as a diagnostic parameter of developing chronic placental insufficiency in pregnant women with monoinfection HIV and co-infection with HIV/HBV or HIV/HCV.

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The prevalence of drug resistance to antiretroviral therapy in the Republic of Mordovia

Laseeva

Власова

Dvoretskova

2023

VIČ-infekc. immunosupr.

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Objective. To study the causes of virological inefficiency of ART and to analyze the prevalence of mutations of resistance to ART drugs among HIV-infected patients, who lives in the Republic of Mordovia and receiving ART.Materials and methods. We studied 37 blood tests with detectable viral load from HIV-infected patients receiving observation in the GBUZ RM «MRTSPBSPID», taking ART for more than 24 weeks. We The evaluated patient’s adherence to treatment. The analysis for drug resistance was performed by genotyping, using HIV-Resist-Seg diagnostic test systems, (the Federal State Budgetary Institution of the Central Research Institute of Rospotrebnadzor, Russia). Statistical data processing (c2 calculation) StatSoft, Inc. (2011), STATISTICA, Russia.Results and discussion: in the group of patients with mutations of resistance to antiretroviral drugs, mutations of pharmacological resistance to drugs of two and three groups are most often determined (in 87.5% of cases). The number and frequency of genetic aberrations in general did not depend on the number of already approved treatment regimens. At the same time, in patients with two or more changes of ART regimens in the anamnesis, the occurrence of mutations of drug resistance to IP was significantly higher than in HIV-infected patients with one ART regimen.Conclusion: in the Republic of Mordovia, virological inefficiency is associated equally with both a violation of ART intake (poor adherence) and the development of pharmacoresistance. It is important to determine the drug resistance of HIV in patients receiving ART.

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The epidemic situation of HIV infection in the Russian Federation in 2019

Cited by 8 publications

References 0 publications

First reported lymphogranuloma venereum cases in Russia discovered in men who have sex with men attending proctologists

First reported lymphogranuloma venereum cases in Russia discovered in men who have sex with men attending proctologists

The predictive value indicators of first trimester biochemical screening in assessing unfavorable factors of pregnancy course in women with HIV as well as hepatitis B and C

The prevalence of drug resistance to antiretroviral therapy in the Republic of Mordovia

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