The Epicardium in Ventricular Septation During Evolution and Development

Poelmann, Robert E.; Jensen, Bjarke; Bartelings, Margot M.; Richardson, Michael K.; Groot, Adriana C. Gittenberger‐de

doi:10.1007/978-4-431-54628-3_13

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…The developing epicardium has also been related to the normal process of ventricular septation [51,52]. During development, the anterior wall of the ventricle folds, forming an interventricular septum and trapping the epicardium in the midline.…”

Section: Ventricular Septal Defectmentioning

confidence: 99%

Deciphering the Involvement of the Epicardium in Cardiac Diseases

Carmona,

López-Sánchez,

García-Martinez

et al. 2023

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The epicardium is a very dynamic cardiac layer with pivotal contributions during cardiogenesis, acting in the postnatal period as an apparently dormant single-cell layer. In mammalian embryos, the epicardium, which originates form the proepicardium, translocates into the pericardial cavity and subsequently rests on the surface of the myocardium. Later, it gives rise to the epicardium-derived cells, which migrate into subepicardial space, invade the developing myocardium, promoting its growth, and contribute to different cell types. Anomalies in the process of epicardial development, the generation of epicardium-derived cells and their signaling mechanisms in different experimental models lead to defective cardiac development, reminiscent of human congenital heart diseases. Furthermore, recent studies have reported that epicardial derivates in adults, i.e., epicardial adipose tissue, are associated with electrophysiological cardiovascular anomalies. Herein, we provide a state-of-the-art review focusing on both congenital and adult heart diseases associated with epicardial development.

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Section: Ventricular Septal Defectmentioning

confidence: 99%