The Enzyme Cyp26b1 Mediates Inhibition of Mast Cell Activation by Fibroblasts to Maintain Skin-Barrier Homeostasis

Kurashima, Yosuke; Amiya, Takeaki; Fujisawa, Kumiko; Shibata, Nao; Suzuki, Yuji; Kogure, Yuta; Hashimoto, Eri; Otsuka, Atsushi; Kabashima, Kenji; Sato, Shintaro; Satô, Takeshi; Kubo, Masato; Akira, Shizuo; Miyake, Kensuke; Kunisawa, Jun; Kiyono, Hiroshi

doi:10.1016/j.immuni.2014.01.014

Cited by 71 publications

(79 citation statements)

References 49 publications

(90 reference statements)

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“…In contrast to other tissues, mast cells in normal human and murine skin express negligible amounts of P2X7 [59,60] , and ATP incubation of these cells fails to cause IL-1b release despite inducing IL-1b release from murine bone marrowderived mast cells [61] . This negligible P2X7 expression on skin mast cells is due to fibroblasts expressing the retinoic acid-degrading enzyme Cyp26b1 [61] . Although the exact mechanism by which these fibroblasts prevent P2X7 expression on skin mast cells is not known, exogenous retinoic acid upregulates P2X7 expression on bone marrow-derived mast cells [61] .…”

Section: Mast Cellsmentioning

confidence: 96%

“…This negligible P2X7 expression on skin mast cells is due to fibroblasts expressing the retinoic acid-degrading enzyme Cyp26b1 [61] . Although the exact mechanism by which these fibroblasts prevent P2X7 expression on skin mast cells is not known, exogenous retinoic acid upregulates P2X7 expression on bone marrow-derived mast cells [61] . This suggests that Cyp26b1-expressing fibroblasts in mice regulate retinoic acid concentrations to suppress P2X7 expression on skin mast cells.…”

Section: Mast Cellsmentioning

confidence: 98%

“…In addition to a role for P2X7 on DCs and macrophages in ICD, P2X7 on mast cells is involved in retinoid-induced ICD. This form of ICD is mediated by aberrant release of ATP within the skin and increased P2X7 expression on skin mast cells [61] . A role for mast cell P2X7 in chemical-induced ICD remains to be determined.…”

Section: Irritant Contact Dermatitismentioning

confidence: 99%

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P2X7 receptor in skin biology and diseases

Geraghty¹,

Watson²,

Adhikary³

et al. 2016

WJD

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The P2X7 receptor is a trimeric ligand-gated cation channel present on immune and other cells. Activation of this receptor by its natural ligand extracellular adenosine triphosphate results in a variety of downstream responses, including the release of pro-inflammatory mediators and cell death. In normal skin, P2X7 is present on keratinocytes, Langerhans cells and fibroblasts, while the presence of this receptor on other cutaneous cells is mainly inferred from studies of equivalent cell types present in other tissues. Mast cells in normal skin however express negligible amounts of P2X7, which can be upregulated in cutaneous disease. This review discusses the potential significance of P2X7 in skin biology, and the role of this receptor in inflammatory skin disorders such as irritant and chronic dermatitis, psoriasis, graft-versus-host disease, as well is in wound healing, transplantation and skin cancer. AbstractThe P2X7 receptor is a trimeric ligand-gated cation channel present on immune and other cells. Activation of this receptor by its natural ligand extracellular adenosine triphosphate results in a variety of downstream responses, including the release of pro-inflammatory mediators and cell death. In normal skin, P2X7 is present on keratinocytes, Langerhans cells and fibroblasts, while the presence of this receptor on other cutaneous cells is mainly inferred from studies of equivalent cell types present in other tissues. Mast cells in normal skin however express negligible amounts of P2X7, which can be upregulated in cutaneous disease. This review discusses the potential significance of P2X7 in skin biology, and the role of this receptor in inflammatory skin disorders such as irritant and chronic dermatitis, psoriasis, graft-versus-host disease, as well is in wound healing, transplantation and skin cancer. Core tip: The P2X7 receptor is present on immune, stromal and epithelial cells. Activation of this receptor by its natural ligand, extracellular adenosine triphosphate, causes a variety of downstream effects including release of inflammatory mediators and growth factors, as well as cell death. P2X7 has various functions on skin cells, and studies of mouse models of disease and of human cells and tissues highlight emerging roles for this receptor in common skin disorders.

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Section: Mast Cellsmentioning

confidence: 96%

Section: Mast Cellsmentioning

confidence: 98%

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P2X7 receptor in skin biology and diseases

Geraghty¹,

Watson²,

Adhikary³

et al. 2016

WJD

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“…Therefore, treatment with 1F11 mAb prevents these pathways and consequently inhibits the development of intestinal inflammation 36) . We recently found that, unlike colonic mast cells, skin mast cells barely expressed P2X7 receptors and skin fibroblasts were involved in the down-regulation of P2X7 receptors on mast cells 22) . Thus, tissue environments determine P2X7 expression on mast cells, which is a critical factor in the development of local inflammation.…”

Section: Mast Cells Mediate the Development Of Intestinal Inflammatiomentioning

confidence: 99%

“…Vitamins are organic compounds that need to be supplied receptor CCR9 18,19) , and the differentiation and activation of T cells 20) , innate lymphoid cells 21) , and mast cells 22) . Another example is vitamin B6, which is required for the metabolic pathway of sphingosine 1-phosphate, a lipid mediator that regulates cell trafficking 23) .…”

Section: Introductionmentioning

confidence: 99%

Vitamin B9 and ATP in the control and development of intestinal inflammation

Kunisawa

2015

Inflammation and Regeneration

Self Cite

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Inflammation, Immunology and Allergy

Steinhoff

2016

Rook's Textbook of Dermatology, Ninth Edition

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Inflammation can be defined as a complex body defence mechanism responding to dangerous endogenous or exogenous stimuli in order to restore body homeostasis. Thus, the skin is continuously challenged to prevent inflammation, and inflammatory skin diseases are very common worldwide. Similarly, allergic reactions (types 1–4) are inflammatory processes created by the body system to respond to ‘danger signals’ of various origins. Very early in phylogenesis, inflammation is associated with the host defence against infectious, allergic or toxic agents, UV radiation, noxious heat and cold, or other injury. Innate and later adaptive immune mechanisms have been established that, uncontrolled, potentially lead to chronic disease or death, as in anaphylactic shock. The body system responds with the induction of various inflammatory pathways such as radical oxygen species, nitric oxide derivatives, complement compounds, adenosine monophosphate, antimicrobial peptides, cytokines, chemokines, prostaglandins, leukotrienes, proteases, neuropeptides and growth factors, just to name a few. This chapter systematically covers the various mechanisms that regulate inflammatory and allergic responses and refers in a translational setting to the diseases that are involved in order better to understand the clinical characteristics of a skin disease, its differential diagnoses and optimal treatment options.

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The Enzyme Cyp26b1 Mediates Inhibition of Mast Cell Activation by Fibroblasts to Maintain Skin-Barrier Homeostasis

Cited by 71 publications

References 49 publications

P2X7 receptor in skin biology and diseases

P2X7 receptor in skin biology and diseases

Vitamin B9 and ATP in the control and development of intestinal inflammation

Inflammation, Immunology and Allergy

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