The environmental release and fate of antibiotics

Manzetti, Sergio; Ghisi, R.

doi:10.1016/j.marpolbul.2014.01.005

Cited by 227 publications

(85 citation statements)

References 81 publications

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“…There are various sources of antibiotics in the aquatic environment. Wastewater from residential facilitates, hospitals, animal husbandry and the pharmaceutical industry is considered as the main source of antibiotics [9][10][11]. The antibiotics taken by humans or animals cannot be fully metabolized, and consequently enter sewage or manure via excreted urine or feces [12].…”

Section: Introductionmentioning

confidence: 99%

Occurrence, Seasonal Variation and Risk Assessment of Antibiotics in Qingcaosha Reservoir

Jiang

et al. 2018

Water

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Qingcaosha Reservoir is an important drinking water source in Shanghai. The occurrence of five groups of antibiotics was investigated in the surface water of this reservoir over a one-year period. Seventeen antibiotics were selected in this study based on their significant usage in China. Of these antibiotics, 16 were detected, while oxytetracycline was not detected in any sampling site. The detected frequency of tylosin was only 47.92% while the other 15 antibiotics were above 81.25%. The dominant antibiotic was different in four seasons: norfloxacin was dominant in spring, and penicillinV was dominant in summer, autumn and winter, with medium concentrations of 124.10 ng/L, 89.91 ng/L, 180.28 ng/L, and 216.43 ng/L, respectively. The concentrations and detection frequencies of antibiotics were notably higher in winter than in other seasons, demonstrating that low temperature and low flow may result in the persistence of antibiotics in the aquatic environment. Risk assessment suggested that norfloxacin, ciprofloxacin, penicillinV, and doxycycline in the surface water presented high ecological risks.

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Section: Introductionmentioning

confidence: 99%

Occurrence, Seasonal Variation and Risk Assessment of Antibiotics in Qingcaosha Reservoir

Jiang

et al. 2018

Water

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“…Research showed that almost 80% to 90% of these compounds were excreted into the environments after initial metabolisms in organisms [4,5]. Finally, high levels of antibiotics were discharged into estuarine ecosystems via river runoff and sewage outfalls from land-based multiple sources, which have negative effects on human health and the safety of estuarine ecosystems [6,7].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Antibiotics on Microbial Community Composition in an Estuary Reservoir during Spring and Summer Seasons

Jiang

et al. 2018

Water

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Abstract:The increased antibiotic pollutants in aquatic environments pose severe threats on microbial ecology due to their extensive distribution and antibacterial properties. A total of 16 antibiotics including fluoroquinolones (FQs) (ofloxacin (OFX), ciprofloxacin (CFX), norfloxacin (NFX)), Sulfonamides (SAs) (sulfamonomethoxine (SMM), sulfadiazine (SDZ), sulfaquinoxaline (SQX)), Tetracyclines (TCs) (tetracycline (TC), doxycycline (DC)), β-lactams (penicillin G (PEN G), penicillin V (PEN V), cefalexin (LEX)), Macrolides (MLs) (erythromycin-H 2 O (ETM), tylosin (TYL)) and other antibiotics (Polymix-B (POL), Vancomycin (VAN), Lincomycin (LIN)) were detected in the surface water of the Qingcaosha Reservoir. Multivariate statistical analysis indicated that both water quality and physicochemical indexes have less contributions on variations of these antibiotics, suggesting the concentrations of antibiotics inside the reservoir are mainly affected by upstream runoff and anthropic activity along the river. Antibiotics including TYL, PEN G and ETM showed significant correlations with variations of bacterial community composition, and closely connected with various gram-negative bacteria in co-occurrence/exclusion patterns of the network, suggesting these bacterial taxa play important roles in the course of migration and transformation of related antibiotics. In conclusion, further research is required to evaluate the potential risk of genetic transfer of resistance to related bacteria induced by long-term exposure to low levels of antibiotics in the environment.

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“…The widespread use of antibiotics in human and veterinary medicine, animal husbandry, plant production and aquaculture has led to high consumption and the gradual accumulation of antibiotics in the environment (e.g., wastewater, landfills, industrial and hospital effluents). [1][2][3][4][5][6] From 100,000 to 200,000 t of antibiotics are consumed per year in hospitals, homes, veterinary use and aquaculture throughout the world. 7 On average, high-income countries generate ca.…”

Section: Introductionmentioning

confidence: 99%

“…5 Upon metabolic processing in humans and animals, these meta-stable compounds yield activated metabolites, which are continuously released in the environment. 4,17,18 The reactive properties of antibioticderived metabolites are largely unknown, as well as the environmental impact of these compounds. Therefore, there is an urgent demand for the development of novel and efficient techniques to minimize water contamination by antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Metal Organic Frameworks for Selective Degradation of Amoxicillin in Biomedical Wastes

Paula

Barros

Wanderley

et al. 2018

J. Braz. Chem. Soc.

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The accumulation of antibiotics in wastewater has led to the development and spreading of antibiotic resistance in the environment. Amoxicillin (Amox), a beta-lactamic antibiotic, is one of the most frequently consumed antibiotics in the world. We have applied two metal-organic frameworks (MOFs) containing zinc(II) as platforms to degrade Amox. We have predicted the adsorption of this antibiotic via molecular docking calculations which have been further corroborated by means of Fourier transform infrared and UV-Vis spectroscopies, thermogravimetric analysis, X-ray diffraction and scanning microscopy measurements. We have subsequently performed mass spectrometry analysis of Amox@zeolitic imidazolate framework-8 (ZIF-8) and Amox@Zn(1,4-benzenedicarboxylate) (ZnBDC) to demonstrate the degradation of Amox upon contact with the Zn-containing frameworks. We propose a possible pathway for the degradation of Amox involving the cleavage of the four-membered β-lactam ring. These Zn-containing frameworks provide a biocompatible platform for the degradation in solution of Amox, which should also be suitable to degrade other β-lactam antibiotics.Keywords: β-lactamase activity, gentamicin, β-lactam catalysis, penicilloic and penilloic acids, biocompatible frameworks IntroductionIn the last decade, antibiotics have emerged as novel environmental pollutants. The widespread use of antibiotics in human and veterinary medicine, animal husbandry, plant production and aquaculture has led to high consumption and the gradual accumulation of antibiotics in the environment (e.g., wastewater, landfills, industrial and hospital effluents). [1][2][3][4][5][6] From 100,000 to 200,000 t of antibiotics are consumed per year in hospitals, homes, veterinary use and aquaculture throughout the world. On average, high-income countries generate ca. 0.5 kg of hazardous waste per bed per day whereas low-income countries generate ca. 0.2 kg. Furthermore, low-income countries do not separate hospital waste into hazardous or non-hazardous wastes, making the real quantity of hazardous waste much higher, as reported by the World Health Organization (WHO).Environmental accumulation of antibiotics has raised serious concerns about the induction of antibiotic resistance. [8][9][10] The exposure of bacteria to the subinhibitory antibiotic concentrations found in many natural environments such as sewage water and sludge, rivers, lakes and even drinking water is a crucial aspect of the current antibiotic resistance crisis.11-14 Furthermore, the incomplete absorption or metabolism of antibiotics in target organisms may lead to excretion rates from 5 to 90% of the dose in the form of metabolites or as parent compounds. 15,16 The chemical structure of antibiotics often contains cyclic moieties such as benzene rings, piperazine units, hexahydropyrimidines, sulfonamides, quinolone, and morpholine groups.5 Upon metabolic processing in humans and animals, these meta-stable compounds yield activated metabolites, which are continuously released in Metal Organic Framewor...

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The environmental release and fate of antibiotics

Cited by 227 publications

References 81 publications

Occurrence, Seasonal Variation and Risk Assessment of Antibiotics in Qingcaosha Reservoir

Occurrence, Seasonal Variation and Risk Assessment of Antibiotics in Qingcaosha Reservoir

The Effects of Antibiotics on Microbial Community Composition in an Estuary Reservoir during Spring and Summer Seasons

Metal Organic Frameworks for Selective Degradation of Amoxicillin in Biomedical Wastes

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