The environmental influence in enzymatic polymerization of aliphatic polyesters in bulk and aqueous mini-emulsion

Målberg, Sofia; Finne‐Wistrand, Anna; Albertsson, Ann‐Christine

doi:10.1016/j.polymer.2010.09.016

Cited by 37 publications

(36 citation statements)

References 25 publications

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“…Among these, are reports about triglyceride hydrolysis [33], ester synthesis [34][35][36][37] and the preparation of polyesters [38,39].…”

Section: Scheme 2 General Structure Of a Triacylglycerol (Triglycerimentioning

confidence: 99%

Section: Polymersmentioning

confidence: 99%

“…As the melting point of PDL is around 35 °C, the reactions were conducted at slightly elevated temperatures of 40 [38] or 45 °C [39]. The data of Målberg et al [38] indicate full conversion of PDL and HDL to polymer after 5 h of reaction (2% Lipase PS, 40 °C). Although a direct comparison is difficult, as the protein contents and the activities of the enzymes may vary, the value agrees with the data of Taden et al [39], who observed full conversion after 4-4.5 h using 0.5% of Lipase PS.…”

Section: Polymersmentioning

confidence: 99%

“…Attempts to use L-lactide (LLA) for the lipase catalyzed synthesis of LLA in miniemulsion were so far not successful [38]. This reaction, however, could be conducted in bulk LLA with ethylene glycol as initiator.…”

Section: Polymersmentioning

confidence: 99%

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Enzymatic Catalysis at Interfaces—Heterophase Systems as Substrates for Enzymatic Action

Weiss

Landfester

2013

Catalysts

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Several important enzymatic reactions occurring in nature, such as, e.g., the digestion of fat, proceed only at the interface of two immiscible phases. Typically, these systems consist of an organic substrate, dispersed in an aqueous continuous phase, with a specialized enzyme capable of working at the interface. For adopting such a system for organic synthesis, a stable heterophase system with a large interfacial area is required. These prerequisites can be found in so-called miniemulsions. Such liquid-liquid heterophase systems feature droplets with sizes smaller than 500 nm, and more importantly, these emulsions do not suffer from Ostwald ripening, as conventional emulsions do. Consequently, the droplets show long-term stability, even throughout reactions conducted in the droplets. In this review, we will briefly discuss the physicochemical background of miniemulsions, provide a comprehensive overview of the enzymatically catalyzed reactions conducted in miniemulsions and, as data are available, to compare the most important features to conventional systems, as reverse microemulsions, (macro)emulsions and solvent-based systems.

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“…Among these, are reports about triglyceride hydrolysis [33], ester synthesis [34][35][36][37] and the preparation of polyesters [38,39].…”

Section: Scheme 2 General Structure Of a Triacylglycerol (Triglycerimentioning

confidence: 99%

Section: Polymersmentioning

confidence: 99%

Section: Polymersmentioning

confidence: 99%

Section: Polymersmentioning

confidence: 99%

See 2 more Smart Citations

Enzymatic Catalysis at Interfaces—Heterophase Systems as Substrates for Enzymatic Action

Weiss

Landfester

2013

Catalysts

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“…Biodegradable polyesters, obtained in this clean process, are used in biomedical applications as scaffolds and in drug delivery systems. Enzymatic ring-opening polymerization (eROP) of lactones can be conducted in the presence of different lipases derived from microorganisms such as: bacteria (Pseudomonas fluorescens [5], Burkholderia cepacia [6,7]), yeast species (Yarrowia lipolytica [8]), lipases of animal origin (porcine pancreas [9]), as well as thermophilic lipase/esterase family enzyme from the archaeon Archaeoglobus fulgidus [10,11], nevertheless during last decades the most intensively studied for this purpose was lipase B from yeast Candida antarctica (CALB). CALB exhibits high polymerization catalytic activity of lactones containing from 4 to 17 membered rings [12], but in the case of lactide, only low molar mass oligomers were achieved [13].…”

Section: Introductionmentioning

confidence: 99%

Candida antarctica Lipase B as Catalyst for Cyclic Esters Synthesis, Their Polymerization and Degradation of Aliphatic Polyesters

et al. 2017

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Optimization of lipase‐catalyzed polymerization of benzyl malolactonate through a design of experiment approach

Casajus

Tranchimand

Wolbert

et al. 2016

J of Applied Polymer Sci

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International audiencePolyesters are polymers of choice in the design of drug delivery systems as a result of their good biocompatibility and their (bio) degradability. Such polyesters are mainly obtained by polymerization techniques using chemically based initiators whose presence in the final materials, even at trace levels, might induce toxic effects on in vivo uses. Therefore, lipases-catalyzed ring opening polymerization (ROP) of lactones might be considered as interesting solutions. In this context, we have studied the possibilities to use lipase-catalyzed ROP of the benzyl malolactonate (MLABe) to obtain the poly(benzyl malate), PMLABe. A Design of Experiment (DoE) approach has been elaborated to identify the important parameters having a significant influence on the polymerization reaction and on the characteristics of the obtained PMLABe. Such DoE technique allowed us to select conditions for lipase-catalyzed ROP of MLABe leading to PMLABe with a mass-average molar mass of around 10,000 g/mol with a dispersity of 1.4. (C) 2016 Wiley Periodicals, Inc

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The environmental influence in enzymatic polymerization of aliphatic polyesters in bulk and aqueous mini-emulsion

Cited by 37 publications

References 25 publications

Enzymatic Catalysis at Interfaces—Heterophase Systems as Substrates for Enzymatic Action

Enzymatic Catalysis at Interfaces—Heterophase Systems as Substrates for Enzymatic Action

Candida antarctica Lipase B as Catalyst for Cyclic Esters Synthesis, Their Polymerization and Degradation of Aliphatic Polyesters

Optimization of lipase‐catalyzed polymerization of benzyl malolactonate through a design of experiment approach

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