The entry of manganese ions into the brain is accelerated by the activation of N-methyl-d-aspartate receptors

Itoh, Kouichi; Sakata, Masakatsu; Watanabe, Masashi; Aikawa, Yoshikatsu; Fujii, Hirotada

doi:10.1016/j.neuroscience.2008.03.080

Cited by 52 publications

(42 citation statements)

References 30 publications

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“…Application of NMDA antagonists such as MK-801 resulted in signal suppression, whereas NMDA agonists such as glutamate and NMDA increased the MEMRI signal in rats. On the other hand, NBQX, an AMPA antagonist, did not influence the signal enhancement in MEMRI experiments (94).…”

Section: Physiological Basismentioning

confidence: 80%

“…No significant distinctions in temporal and regional T 1 changes were reported for subcutaneous, intraperitoneal, and intravenous injections (93,94). The best way of administration therefore depends on the desired temporal resolution (e.g., subcutaneous injections significantly delay the peak plasma concentration), the manganese concentration (e.g., intravenous injections allow for higher concentrations, but hold a high risk of heart failure), and other practical considerations (e.g., in mice, intraperitoneal injections are much easier to perform than intravenous injections).…”

Section: Routes Of Manganese Administrationmentioning

confidence: 99%

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Manganese-Enhanced Magnetic Resonance Imaging

Boretius

Frahm

2011

Methods in Molecular Biology

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Manganese-enhanced magnetic resonance imaging (MEMRI) relies on contrasts that are due to the shortening of the T (1) relaxation time of tissue water protons that become exposed to paramagnetic manganese ions. In experimental animals, the technique combines the high spatial resolution achievable by MRI with the biological information gathered by tissue-specific or functionally induced accumulations of manganese. After in vivo administration, manganese ions may enter cells via voltage-gated calcium channels. In the nervous system, manganese ions are actively transported along the axon. Based on these properties, MEMRI is increasingly used to delineate neuroanatomical structures, assess differences in functional brain activity, and unravel neuronal connectivities in both healthy animals and models of neurological disorders. Because of the cellular toxicity of manganese, a major challenge for a successful MEMRI study is to achieve the lowest possible dose for a particular biological question. Moreover, the interpretation of MEMRI findings requires a profound knowledge of the behavior of manganese in complex organ systems under physiological and pathological conditions. Starting with an overview of manganese pharmacokinetics and mechanisms of toxicity, this chapter covers experimental methods and protocols for applications in neuroscience.

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Section: Physiological Basismentioning

confidence: 80%

Section: Routes Of Manganese Administrationmentioning

confidence: 99%

Manganese-Enhanced Magnetic Resonance Imaging

Boretius

Frahm

2011

Methods in Molecular Biology

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“…Manganese has an life-time of 2-3 weeks after a single injection. Pharmacological experiments using glutamate receptor pharmacology have shown that the magnesium-dependent signal enhancement results from the activation of glutamatergic neurons through NMDA (N-methyl-D-aspartate) receptors, but not through AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors [101]. Odor-induced activity recordings with functional MEMRI were first demonstrated by Pautler and Koretsky [102].…”

Section: Cellular Basis Of Gcamp2 Signalsmentioning

confidence: 99%

Visualizing odor representation in the brain: a review of imaging techniques for the mapping of sensory activity in the olfactory glomeruli

Pain

L'Heureux

Gurden

2011

Cell. Mol. Life Sci.

111

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“…Mn 2þ as a positive contrast agent in T 1 W MRI has long been used in many biologic applications for brain mapping (26), brain disease (12) (27), neuronal tract tracing (28), and cardiac functional studies (29). Although several factors influencing Mn 2þ uptake in cells have been reported such as voltage-gated Ca 2þ -channel activities (30)(31)(32)(33), NMDA (14) and calcium-sensing receptor (34) expression, astroglia (27) and microglia (35) activity/cellularity, activities of enzymes (e.g., manganese superoxide dismutase; refs. 36, 37) and metal transporters, the mechanisms involved in Mn 2þ uptake in tumor cells are not well known.…”

Section: Discussionmentioning

confidence: 99%

“…The underlying principle of MEMRI lies in the fact that Mn 2þ behaves in a manner similar to the calcium ion (Ca 2þ ) in many biologic systems (13). Extracellular Mn 2þ can enter cells through N-methyl-D-aspartate (NMDA) receptors for glutamate (14) and/or voltage-gated calcium channels (15). Previous studies have found that MEMRI is useful for the in vivo visualization of tumors such as those arising from head and neck region (16,17).…”

Section: Introductionmentioning

confidence: 99%