The enthalpies of dilution of some dipeptides in water at 298.15 K

Belica-Pacha, Sylwia; Michalska-Tężycka, Martyna; Ciechańska, Magdalena; Stępniak, Artur; Pałecz, Bartłomiej

doi:10.1016/j.jct.2020.106338

Cited by 2 publications

(1 citation statement)

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“…The choice of an appropriate proprietary solvent can be crucial for the development of formulations and new drugs. The behavior of amino acids and peptides in aqueous solution can be significantly influenced by even small additions of inorganic salts, alcohols, amides, and other organic solvents. − This work is a continuation of the study of the thermodynamics of the dissolution and solvation of glycyl- l -alanine (I) in aqueous solutions of various organic solvents . As our previous studies have shown, changes in the concentration of an organic solvent and, in particular, its structure and physicochemical properties significantly affect the intermolecular interactions of peptides and organic cosolvents.…”

Section: Introductionmentioning

confidence: 91%

Features of the Solvation of Glycyl-l-alanine in Various Aqueous–Organic Mixtures at T = 298.15 K

Smirnov

2024

J. Chem. Eng. Data

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In the present work, an assessment of the processes of glycyl-L-alanine solvation is given when the nature of an aqueous− organic mixture changes. For this purpose, the enthalpies of the glycyl-L-alanine dissolution in aqueous solutions of ethanol, 1-propanol, 2propanol, acetonitrile, 1,4-dioxane, acetone, and dimethyl sulfoxide were measured by isothermal calorimetry at T = 298.15 K. Corresponding enthalpies of solvation (Δ solv H°) were determined by combining the obtained values (Δ sol H°) with the standard enthalpies (Δ sub H°) of glycyl-L-alanine sublimation. In addition, we derived the enthalpic coefficients of the pairwise interactions (h xy ) between glycyl-L-alanine and organic solvent molecules, as well as the transfer enthalpies (Δ tr H°) from water in admixture with them. A comparative analysis of changes in the transfer enthalpies of glycyl-L-alanine, glycylglycine and glycyl-L-tyrosine from water to similar water−organic mixtures is presented. The modified Kamlet−Taft equation was used to quantify the contribution of some physicochemical properties of organic solvents (polarity/polarizability, cohesion energy density, basicity, and acidity) to the energy of intermolecular interactions of glycyl-L-alanine−cosolvent.

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