The ENPP1 K121Q polymorphism modulates developing of bone disorders in type 2 diabetes: A cross sectional study

Neamati, Nahid; Hosseini, Seyed Reza; Hajiahmadi, Mahmood; Halalkhor, Sohrab; Nooreddini, Hajighorban; Niaki, Haleh Akhavan; Korani, Bahare; Parsian, Hadi

doi:10.1016/j.gene.2017.09.042

Cited by 6 publications

(2 citation statements)

References 31 publications

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“…However, it has been observed that zinc deficiency can impair the activities of some ectoenzymes, including ENPP1. Hale et al, 2012Neamati et al, 2017 Gohari-Lasaki et al, 2020…”

Section: Future Perspectivesmentioning

confidence: 99%

“…In addition, SNPs in the promoter region of the HNF4A gene were correlated with predisposition to T2DM ( Bartoov-Shifman et al, 2002 ). Finally, the ENPP1 gene inhibits insulin receptor signaling, which is why it is related to the development of insulin resistance when overexpressed ( Bacci et al, 2007 ; Neamati et al, 2017 ).…”

Section: Genes Related To Type 2 Diabetes Mellitusmentioning

confidence: 99%

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Nutrigenomics in Regulating the Expression of Genes Related to Type 2 Diabetes Mellitus

et al. 2021

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Nutrigenomics is the study of the gene-nutrient interaction and it indicates that some nutrients, called bioactive compounds, can mold the genetic expression or change the nucleotide chain. Polyphenols are secondary metabolites found in plants that are regularly consumed in functional foods and help prevent or delay the onset of type 2 diabetes mellitus (T2DM) and its complications. This article objected to review studies about the interaction of diet with polyphenols and Mediterranean diet in the expression of human genes related to T2DM. Resveratrol acts as an antioxidant, anti-inflammatory, and increases mitochondrial function. Regular consumption of quercetin resulted in improvement of hypertension and suppression of diabetes-induced vasoconstriction. Genistein also showed positive results in T2DM, such as increased cell mass and improved glucose tolerance and insulin levels. Catechins showed efficiency in inducing genes in triacylglycerol biosynthesis, inhibition of fatty acids and cholesterol, and resulting in their participation in mitigating complications of diabetes. Lastly, curcumin was demonstrated to be a protector of the pancreatic islets against streptozotocin-induced oxidative stress. Growing evidence suggest that bioactive compounds such as polyphenols have an important role in T2DM and the prevention and treatment of its complication, as they cause activation or inhibition of related genes.

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“…However, it has been observed that zinc deficiency can impair the activities of some ectoenzymes, including ENPP1. Hale et al, 2012Neamati et al, 2017 Gohari-Lasaki et al, 2020…”

Section: Future Perspectivesmentioning

confidence: 99%