The Enlarged Sella and the Intrasellar Cistern

Zatz, Leslie M.; Janon, Edward A.; Newton, Thomas H.

doi:10.1148/93.5.1085

Cited by 40 publications

(2 citation statements)

References 10 publications

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“…The case of an empty sella associated with CSF rhinorrhea (Case 6) has to be added to the two described by Ommaya, et al, ~ the one studied by Zatz,et al,21 and the four found by Brisman, et al? In addition to an overall enlargement of the seUar cavity, there was an asymmetrical expansion under one anterior clinoid.…”

Section: Discussionmentioning

confidence: 99%

Primary empty sella

Bernasconi¹,

Giovanelli²,

Papo³

1972

Journal of Neurosurgery

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Section: Discussionmentioning

confidence: 99%

Primary empty sella

Bernasconi¹,

Giovanelli²,

Papo³

1972

Journal of Neurosurgery

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“…In spite of many publications however, this problem remains unresolved. Apparently everything has already been described: no concurrent endocrine disorder at all, panhypopituitarism (Caplan et al 1969;Neelon et al 1973), GH, LH or ACTH deficiency (Neelon et al 1973;Brisman et al 1972;Faglia et al 1973), amenorrhoea associated with galactorrhoea (Gates et al 1973;Jacobs 8c Daughaday 1969), acromegaly (Hardy 1969;Andrioli et al 1970;Zatz et al 1969), diabetes insipidus (Matissonn 8c Pimstone 1973), primary hypothyroidism (Neelon et al 1973), Turner's syndrome (Odell 1973) and virilization (Shore et al 1974).…”

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confidence: 99%

The Primary Empty Sella an Endocrine Study on 12 Cases

Schaison

Metzger

1976

Acta Endocrinologica

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Twelve patients (10 women and 2 men) with a primary empty sella turcica were studied. Endocrine function tests were performed as follows: growth hormone (GH) was measured after insulin-induced-hypoglycaemia, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) after LH-releasing hormone, thyrotrophin (TSH) and prolactin after thyrotrophin-releasing hormone; pituitary reserve of adrenocorticotrophin (ACTH) was determined by measurement of plasma cortisol after lysinevasopressin and 11 deoxycortisol after metyrapone. Five of the patients (group A) had no endocrine disturbance. Seven patients (group B) had a hypothalamo-pituitary disorder. Two of them had panhypopituitarism which appeared in one case after meningoencephalitis and in the other after a severe cranial trauma. In two cases an amenorrhoea-galactorrhoea syndrome with increased prolactin level (68 and 230 ng/ml) led to a diagnosis of a prolactin producing adenoma, which was confirmed by surgery. Finally three cases of amenorrhoeagalactorrhoea, with normal prolactin level, and/or diabetes insipidus remained unexplained. However, no causal relationship could be demonstrated between the pituitary disturbance and the "empty sella". Primary empty sella turcica is therefore a neuroanatomical and neuroradiological entity with no endocrine implication. A pituitary disorder might suggest a microadenoma or an incidentally associated disease.The term primary empty sella is used to denote intrasellar arachnoid invagina¬ tion of the chiasmatic cistern probably due to incomplete congenital development of the sellar diaphragm (Busch 1951). It also includes intrasellar arachnoidal cyst and even spontaneous necrosis of pituitary adenomas which are often Hôpital de la Pitié, 75013 -Paris

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