The Enigma of Spontaneous Preterm Birth

Muglia, Louis J.; Katz, Michael

doi:10.1056/nejmra0904308

Cited by 605 publications

(480 citation statements)

References 38 publications

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“…Considerando o perfil de mães para o nascimento de bebês prematuros e a termo, há a incógnita no meio científico. O parto pré-termo resulta de fatores inter-relacionados em que os estudos apontam associação com problemas na preconcepção ou durante a gestação, aspectos ambientais e sociais, e altos índices de cesáreas sem indicação antes da maturidade fetal (2,(8)(9)(10) . Assim, a teorização que embasa esta pesquisa é a teoria de risco, sendo o termo risco definido como "probabilidade de um membro de uma população definida desenvolver uma dada doença em um período de tempo".…”

Section: Introductionunclassified

Perfil De Mães E O Desfecho Do Nascimento Prematuro Ou a Termo

et al. 2018

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RESUMO:Objetivo: identificar o perfil de mães de bebês prematuros e a termo para o desfecho do nascimento. Método: trata-se de um estudo analítico-descritivo, seccional, com amostra de 244 puérperas, sendo 109 mães de bebês prematuros e 135 mães de bebês a termo, por partos ocorridos no período de abril a setembro de 2015, em uma maternidade pública do nordeste brasileiro. Os dados foram analisados pelo programa Statistica 10 e teste Qui-quadrado. Resultados: alta prevalência de sedentarismo; significância estatística para sobrepeso e obesidade antes e durante a gravidez; elevada prevalência de pressão arterial alta durante a gestação das mães de bebês prematuros. Logo, os bebês nasceram com problemas de saúde em 58,1% (n= 63) dos prematuros e nascimento saudável em 96,3% (n= 130) dos bebês a termo. Conclusão: o perfil de mães com obesidade e sobrepeso é fator de risco ao nascimento do bebê prematuro como evento que demanda cuidado à saúde da criança. DESCRITORES: Prematuro; Cuidado Pré-Natal; Parto; Fatores de Risco; Enfermagem Materno-Infantil. PERFIL DE MÃES E O DESFECHO DO NASCIMENTO PREMATURO OU IMPACT OF MATERNAL PROFILE ON BIRTH OUTCOMESABSTRACT: Objective: to identify the impact of maternal profile on birth outcomes. Method: Descriptive cross-sectional study with a sample of 244 postpartum women, as follows: 109 mothers of preterm infants and 135 mothers of full-term infants. The births occurred in the April-September 2015 period in a public maternity hospital in the Northeastern region of Brazil. Data was analyzed with Statistica 10 software and Chi-square test. Results: high prevalence of sedentary lifestyle; statistical significance for overweight and obesity before and during pregnancy; high prevalence of high blood pressure during the gestational period of mothers of preterm infants. Also, 58.1% (n = 63) of preterm infants were born with health problems and 96.3% (n = 130) of full-term infants were healthy. Conclusion: Maternal obesity and overweight is a risk factor for preterm births, an event that demands child healthcare. DESCRIPTORS: Preterm; Prenatal care; Childbirth; Risk Factors; Maternal-Child Nursing. PERFIL DE MADRES Y EL DESENLACE DEL NACIMIENTO PREMATURO O A TÉRMINO RESUMEN:Objetivo: identificar el perfil de madres de bebés prematuros y a término para el desenlace del nacimiento. Método: es un estudio analítico descriptivo, seccional, con muestra de 244 puérperas, siendo 109 madres de bebés prematuros y 135 madres de bebés a término, por partos ocurridos el periodo de abril a septiembre de 2015, en una maternidad pública de nordeste de Brasil. Se analizaron los datos por medio del programa Statistica 10 y test Chi-cuadrado. Resultados: hubo grande prevalencia de sedentarismo; significancia estadística para sobrepeso y obesidad antes y durante la gravidez; alta prevalencia de presión arterial alta durante la gestación de las madres de bebés prematuros. De ese modo, 58,1% (n= 63) de los bebés prematuros nacieron con problemas de salud y de los bebés a término hubo nacimiento saludable e...

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Section: Introductionunclassified

Perfil De Mães E O Desfecho Do Nascimento Prematuro Ou a Termo

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“…Premature neonates have heightened vulnerability to brain damage. This specific subpopulation of newborns is growing due to the increased rate of preterm birth (Muglia and Katz, 2010). Unfortunately treatment options remain very limited, especially in preterm newborns.…”

Section: Introductionmentioning

confidence: 99%

Postnatal administration of IL-1Ra exerts neuroprotective effects following perinatal inflammation and/or hypoxic-ischemic injuries

Girard¹,

Sébire²,

Brochu³

et al. 2012

Brain, Behavior, and Immunity

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New therapeutic strategies are needed to protect neonates, especially premature newborns, against brain injury and associated neurobehavioral deficits. The role of pro-inflammatory cytokines, especially IL-1β, in the pathophysiological pathway leading to neonatal brain damage is increasingly recognized and represents an attractive therapeutic target. We investigated the therapeutic potential of postnatal systemic administration of the interleukin (IL)-1 receptor antagonist (IL-1Ra) in an animal model of perinatal brain injury using the insults most common to human neonates, i.e. prenatal exposure to inflammation and/or postnatal hypoxia-ischaemia (HI). We found that postnatal administration of IL-1Ra preserved motor function and exploratory behavior after either prenatal exposure to inflammatory agent lipopolysaccharide (LPS) or postnatal HI insult. The deleterious effect of combined prenatal LPS and postnatal HI on brain development was also alleviated by administration of IL-1Ra, as seen by the protected neural stem cell population, prevention of myelin loss in the internal capsule, decreased gliosis, and decreased neurobehavioral impairment. This study showed the distinct pattern of functional deficits induced by prenatal inflammation as compared to postnatal HI and the therapeutic potential of IL-1Ra administration against neonatal brain injury. Furthermore, our results highlight the potential for postnatal treatment of prenatal inflammatory stressors.

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“…H igh rates of premature birth are common in most high-income countries and impose significant health problems and a heavy economic burden on society [1]. Prematurity is associated with a broad spectrum of respiratory symptoms and lung function abnormalities, starting early in life and possibly lasting into adulthood [2].…”

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Evidence of unexpected oxidative stress in airways of adolescents born very pre-term

Filippone¹,

Bonetto²,

Corradi

et al. 2012

Eur Respir J

102

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Prematurity and its main respiratory complication, bronchopulmonary dysplasia (BPD), are potentially associated with lifelong respiratory morbidities and/or lung function abnormalities. The mechanisms behind these long-term respiratory problems are still unclear.We assessed airway oxidative stress in adolescents born very pre-term (f32 gestational weeks) by measuring 8-isoprostane concentration in exhaled breath condensate (EBC). In addition, the study protocol included spirometry and measurement of exhaled nitric oxide fraction (FeNO).The study groups included 34 ex-pre-term adolescents with BPD, 18 ex-pre-term adolescents without BPD and 34 healthy controls born at term.Regardless of a history of BPD, the ex-premature adolescents had higher EBC 8-isoprostane levels (median (interquartile range) BPD 9.5 (7.3-12.2) pg?mL -1 ; pre-term non-BPD 10 (8.1-16) pg?mL -1 ) than the controls (3.2 (1.9-6.5) pg?mL -1 ) (p,0.001). Forced expiratory volume in 1 s was lower in the BPD group (mean¡SD Z-score -2.1¡1.58) than in the pre-term non-BPD individuals (-1.13¡1.15), who showed in turn significantly lower values than the controls (0.18¡0.83; p,0.001). FeNO was similar in the three groups (p50.55).Our data show that, after premature birth, evidence of oxidative stress in the airways may be detected into adolescence, suggesting that long-term respiratory abnormalities after pre-term birth may be associated with an ongoing airway disease and not just a stabilised structural lung damage.

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The Enigma of Spontaneous Preterm Birth

Cited by 605 publications

References 38 publications

Perfil De Mães E O Desfecho Do Nascimento Prematuro Ou a Termo

Perfil De Mães E O Desfecho Do Nascimento Prematuro Ou a Termo

Postnatal administration of IL-1Ra exerts neuroprotective effects following perinatal inflammation and/or hypoxic-ischemic injuries

Evidence of unexpected oxidative stress in airways of adolescents born very pre-term

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