The enigma of an EBV - Positive mucocutaneous ulcer: A case report and brief review of literature

Mulchandani, Nikita J.; Kurian, Achamma; Kalaichelvi, K.; Subbiah, Kannan; Subramanyan, Annapurneswari

doi:10.1016/j.hpr.2022.300591

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…The ulcer may regress after the reduction or discontinuation of immunosuppressive therapy without requiring additional treatment. Some cases require more aggressive treatment, such as chemotherapy, resection, and radiotherapy [4][5][6]. However, there are no established standards of treatment for this disease, and the optimal dose-fractionation regimens for radiation therapy remain to be established [7].…”

Section: Introductionmentioning

confidence: 99%

Radiotherapy for Epstein-Barr Virus-Positive Mucocutaneous Ulcer at the Lower Leg Skin: A Case Report

Kubo¹,

Okano²,

Kawamura³

et al. 2022

Cureus

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Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is a rare lymphoproliferation and a relatively benign condition. Although the condition can be cured without treatment, some cases require chemotherapy, resection, or radiotherapy. However, there are no established standards regarding the dose and schedule of radiation therapy. We present the case of a 44-year-old female with a history of living donor kidney transplantation who developed EBVMCU in the right lower leg after 23 years. She did not improve with conservative therapy and was treated with low-dose radiotherapy (4 Gy in two fractions) to the EBVMCU on the lower leg skin. The patient achieved complete control after one year without toxic effects. This case report provides evidence that low-dose radiotherapy is a potentially effective treatment for EBVMCU in patients who do not improve with observation or by decreasing immunosuppressive therapy.

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Section: Introductionmentioning

confidence: 99%

Radiotherapy for Epstein-Barr Virus-Positive Mucocutaneous Ulcer at the Lower Leg Skin: A Case Report

Kubo¹,

Okano²,

Kawamura³

et al. 2022

Cureus

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Multifocal Epstein-Barr Virus-Positive Mucocutaneous Ulcers in a Patient With Crohn's Disease

Alphonsus,

Zhang,

Jairath

2024

ACG Case Rep J

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Epstein-Barr Virus-positive mucocutaneous ulcer (EBVMCU) is a rare and new category of mature B-cell neoplasms commonly linked to immunosuppression. It often has a benign course and regresses spontaneously after discontinuation or dose reduction of immunosuppressive agents. We report the case of a 48-year-old woman on long-term azathioprine therapy for rectosigmoid Crohn's disease. In contrast to the prevalent sites typically associated with EBVMCU, such as the oral mucosa and skin, this patient was found to have locations in the gastrointestinal tract and upper neck. These areas tested positive for histopathology consistent with EBVMCU and were excised due to bowel perforation and concern for malignancy.

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The enigma of an EBV - Positive mucocutaneous ulcer: A case report and brief review of literature

Cited by 2 publications

References 48 publications

Radiotherapy for Epstein-Barr Virus-Positive Mucocutaneous Ulcer at the Lower Leg Skin: A Case Report

Radiotherapy for Epstein-Barr Virus-Positive Mucocutaneous Ulcer at the Lower Leg Skin: A Case Report

Multifocal Epstein-Barr Virus-Positive Mucocutaneous Ulcers in a Patient With Crohn's Disease

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