The enhanced anticoagulation for graphene induced by COOH+ ion implantation

Liu, Xiaoqi; Cao, Ye; Zhao, Mengli; Deng, Jianhua; Li, Xifei; Li, Dejun

doi:10.1186/s11671-014-0705-2

Cited by 19 publications

(7 citation statements)

References 37 publications

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“…Earlier publications have revealed that the FGNs will induce obvious toxicity when nanodispersed FGNs are exposed in living system, especially for applications in nanomedicine . However, recent studies have indicated that, when FGNs are applied for the surface coating of implants or membranes, no obvious blood and cell toxicity has been observed. − It is believed that the reduced “face-to-edge” contact between the cell membrane and FGNs-based coatings may be the main reason for their enhanced cell adhesion and proliferation of modified implants. The nitinol alloy is often used as a biomedical implant due to its superior mechanical properties.…”

Section: Emerging Biological Applications Of Fgns-based Architecturesmentioning

confidence: 99%

Functional Graphene Nanomaterials Based Architectures: Biointeractions, Fabrications, and Emerging Biological Applications

et al. 2017

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Functional graphene nanomaterials (FGNs) are fast emerging materials with extremely unique physical and chemical properties and physiological ability to interfere and/or interact with bioorganisms; as a result, FGNs present manifold possibilities for diverse biological applications. Beyond their use in drug/gene delivery, phototherapy, and bioimaging, recent studies have revealed that FGNs can significantly promote interfacial biointeractions, in particular, with proteins, mammalian cells/stem cells, and microbials. FGNs can adsorb and concentrate nutrition factors including proteins from physiological media. This accelerates the formation of extracellular matrix, which eventually promotes cell colonization by providing a more beneficial microenvironment for cell adhesion and growth. Furthermore, FGNs can also interact with cocultured cells by physical or chemical stimulation, which significantly mediate their cellular signaling and biological performance. In this review, we elucidate FGNs-bioorganism interactions and summarize recent advancements on designing FGN-based two-dimensional and three-dimensional architectures as multifunctional biological platforms. We have also discussed the representative biological applications regarding these FGN-based bioactive architectures. Furthermore, the future perspectives and emerging challenges will also be highlighted. Due to the lack of comprehensive reviews in this emerging field, this review may catch great interest and inspire many new opportunities across a broad range of disciplines.

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Section: Emerging Biological Applications Of Fgns-based Architecturesmentioning

confidence: 99%

Functional Graphene Nanomaterials Based Architectures: Biointeractions, Fabrications, and Emerging Biological Applications

et al. 2017

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“…[59,61] Large surface areas of nanomaterials [e.g., graphene oxide (GO), multiwalled carbon nanotubes] [30,62] with abundant -COOH groups may enhance the anticoagulant activity of composite nanocoatings. [63] A 16-phosphonylhexadecanoic acid/chitosan-functionalized GO (GOCS) composite coating prepared on AZ31B Mg alloy decreased platelet adhesion (to ≈59% of that of bare metal) and activation, as evidenced by a 48% increased expression of cyclic guanosine monophosphate (cGMP), which reflects platelet inhibition. In addition, the composite nanocoating exhibited more potent anti-platelet activity than the unmodified 16-phosphonyl-hexadecanoic acid coating; platelet adhesion was inhibited by 43% and the concentration of cGMP was increased by 22%.…”

Section: Preventing Vascular Stent Thrombosis and Restenosismentioning

confidence: 99%

Composite Nanocoatings of Biomedical Magnesium Alloy Implants: Advantages, Mechanisms, and Design Strategies

Dai

Xiong

et al. 2023

Advanced Science

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The rapid degradation of magnesium (Mg) alloy implants erodes mechanical performance and interfacial bioactivity, thereby limiting their clinical utility. Surface modification is among the solutions to improve corrosion resistance and bioefficacy of Mg alloys. Novel composite coatings that incorporate nanostructures create new opportunities for their expanded use. Particle size dominance and impermeability may increase corrosion resistance and thereby prolong implant service time. Nanoparticles with specific biological effects may be released into the peri‐implant microenvironment during the degradation of coatings to promote healing. Composite nanocoatings provide nanoscale surfaces to promote cell adhesion and proliferation. Nanoparticles may activate cellular signaling pathways, while those with porous or core–shell structures may carry antibacterial or immunomodulatory drugs. Composite nanocoatings may promote vascular reendothelialization and osteogenesis, attenuate inflammation, and inhibit bacterial growth, thus increasing their applicability in complex clinical microenvironments such as those of atherosclerosis and open fractures. This review combines the physicochemical properties and biological efficiency of Mg‐based alloy biomedical implants to summarize the advantages of composite nanocoatings, analyzes their mechanisms of action, and proposes design and construction strategies, with the purpose of providing a reference for promoting the clinical application of Mg alloy implants and to further the design of nanocoatings.

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“…The anticoagulation property of COOH + -functionalized graphene correlated with the surface wettability of the substrate. 75 Surface functionalization of graphene substrates provides additional chemical and physical properties for enhanced cell response. The addition of small chemical moieties on graphene or GO altered the cell−material interactions.…”

Section: Functionalized Graphene-derived Particlesmentioning

confidence: 99%

Comprehensive Review on the Use of Graphene-Based Substrates for Regenerative Medicine and Biomedical Devices

Kumar

Chatterjee

2016

ACS Appl. Mater. Interfaces

139

113

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Recent research suggests that graphene holds great potential in the biomedical field because of its extraordinary properties. Whereas initial attempts focused on the use of suspended graphene for drug delivery and bioimaging, more recent work has demonstrated its advantages for preparing substrates for tissue engineering and biomedical devices and products. Cells are known to interact with and respond to nanoparticles differently when presented in the form of a substrate than in the form of a suspension. In tissue engineering, a stable and supportive substrate or scaffold is needed to provide mechanical support, chemical stimuli, and biological signals to cells. This review compiles recent advances of the impact of both graphene and graphene-derived particles to prepare supporting substrates for tissue regeneration and devices as well as the associated cell response to multifunctional graphene substrates. We discuss the interaction of cells with pristine graphene, graphene oxide, functionalized graphene, and hybrid graphene particles in the form of coatings and composites. Such materials show excellent biological outcomes in vitro, in particular, for orthopedic and neural tissue engineering applications. Preliminary evaluation of these graphene-based materials in vivo reinforces their promise for tissue regeneration and implants. Although the reported findings of studies on graphene-based substrates are promising, several questions and concerns associated with their in vivo use persist. Possible strategies to examine these issues are presented.

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The enhanced anticoagulation for graphene induced by COOH+ ion implantation

Cited by 19 publications

References 37 publications

Functional Graphene Nanomaterials Based Architectures: Biointeractions, Fabrications, and Emerging Biological Applications

Functional Graphene Nanomaterials Based Architectures: Biointeractions, Fabrications, and Emerging Biological Applications

Composite Nanocoatings of Biomedical Magnesium Alloy Implants: Advantages, Mechanisms, and Design Strategies

Comprehensive Review on the Use of Graphene-Based Substrates for Regenerative Medicine and Biomedical Devices

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