The energetic and physical concept of gold nanorod-dependent fluorescence in cancer treatment and development of new photonic compounds|review

Alshangiti, Dalal Mohamed; Ghobashy, Mohamed Mohamady; Alqahtani, Haifa A.; El-damhougy, Tasneam K.; Madani, Mohamed

doi:10.1039/d3ra05487j

Cited by 6 publications

(3 citation statements)

References 172 publications

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“…However, the synthesis process for its corrugated surface presents challenges in terms of reproducibility and scalability. In contrast, GNRs offer versatility in their optical properties, allowing for tunable absorption wavelengths [39,40]. Surface modifications enable targeted cellular uptake, enhancing the specificity of intracellular delivery.…”

Section: Au-pnp-peg-and Gnr-peg-mediated Intracellular Deliverymentioning

confidence: 99%

Laser-Induced Intracellular Delivery: Exploiting Gold-Coated Spiky Polymeric Nanoparticles and Gold Nanorods under Near-Infrared Pulses for Single-Cell Nano-Photon-Poration

Kumar,

Nahak,

Gupta

et al. 2024

Micromachines

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This study explores the potential of laser-induced nano-photon-poration as a non-invasive technique for the intracellular delivery of micro/macromolecules at the single-cell level. This research proposes the utilization of gold-coated spiky polymeric nanoparticles (Au-PNPs) and gold nanorods (GNRs) to achieve efficient intracellular micro/macromolecule delivery at the single-cell level. By shifting the operating wavelength towards the near-infrared (NIR) range, the intracellular delivery efficiency and viability of Au-PNP-mediated photon-poration are compared to those using GNR-mediated intracellular delivery. Employing Au-PNPs as mediators in conjunction with nanosecond-pulsed lasers, a highly efficient intracellular delivery, while preserving high cell viability, is demonstrated. Laser pulses directed at Au-PNPs generate over a hundred hot spots per particle through plasmon resonance, facilitating the formation of photothermal vapor nanobubbles (PVNBs). These PVNBs create transient pores, enabling the gentle transfer of cargo from the extracellular to the intracellular milieu, without inducing deleterious effects in the cells. The optimization of wavelengths in the NIR region, coupled with low laser fluence (27 mJ/cm2) and nanoparticle concentrations (34 µg/mL), achieves outstanding delivery efficiencies (96%) and maintains high cell viability (up to 99%) across the various cell types, including cancer and neuronal cells. Importantly, sustained high cell viability (90–95%) is observed even 48 h post laser exposure. This innovative development holds considerable promise for diverse applications, encompassing drug delivery, gene therapy, and regenerative medicine. This study underscores the efficiency and versatility of the proposed technique, positioning it as a valuable tool for advancing intracellular delivery strategies in biomedical applications.

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Section: Au-pnp-peg-and Gnr-peg-mediated Intracellular Deliverymentioning

confidence: 99%

Laser-Induced Intracellular Delivery: Exploiting Gold-Coated Spiky Polymeric Nanoparticles and Gold Nanorods under Near-Infrared Pulses for Single-Cell Nano-Photon-Poration

Kumar,

Nahak,

Gupta

et al. 2024

Micromachines

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“…To improve the light absorption of GO-AuNR for PPTT, researchers are designing particles with specific sizes, shapes, and compositions that match the wavelength of light that will be used for treatment 46 . Another approach is to coat P-NPs with a material that can enhance their light absorption.…”

Section: Limitations Of Plasmonic Nanohybridsmentioning

confidence: 99%

Surface engineered nanohybrids in plasmonic photothermal therapy for cancer: Regulatory and translational challenges

Debnath,

Talpade

et al. 2024

Nanotheranostics

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Plasmonic materials as non-invasive and selective treatment strategies are gaining increasing attention in the healthcare sector due to their remarkable optical and electronic properties, where the interface between matter and light becomes enhanced and highly localized. Some attractive applications of plasmonic materials in healthcare include drug delivery to target specific tissues or cells, hence reducing the side effects of the drug and improving their efficacy; enhancing the contrast and resolution in bioimaging; and selectively heating and destroying the cancerous cells while parting the healthy cells. Despite such advancements in photothermal therapy for cancer treatment, some limitations are still challenging. These include poor photothermal conversion efficiency, heat resistance, less accumulation in the tumor microenvironment, poor biosafety of photothermal agents, damage to the surrounding healthy tissues, post-treatment inflammatory responses, etc. Even though the clinical application of photothermal therapy is primarily restricted due to poor tissue penetration of excitation light, enzyme therapy is hindered due to less therapeutic efficacy. Several multimodal strategies, including chemotherapy, radiotherapy, photodynamic therapy, and immunotherapy were developed to circumvent these side effects associated with plasmonic photothermal agents for effective mild-temperature photothermal therapy. It can be prophesied that the nanohybrid platform could pave the way for developing cutting-edge multifunctional precise nanomedicine via an ecologically sustainable approach towards cancer therapy. In the present review, we have highlighted the significant challenges of photothermal therapy from the laboratory to the clinical setting and their struggle to get approval from the Food and Drug Administration (FDA).

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“…The Food and Drug Administration (FDA) has granted synthetic amorph silica the generally recognized as safe (GRAS) status for its use as additives in both food and cosmetics. 11–15 The ordered mesoporous silica materials such as MCM, SBA, and KIT are silica-based nanomaterials that have amorphous properties but have various superior properties as follows: very regular mesophase structure, uniform distribution of pores, high surface area, and pore volume (high surface area can reach 1000 m 2 g −1 and pore volume can reach 1 cm 3 g −1 ), the chemical composition that can be engineered, surface that can be modified, and pore size and morphology that can be controlled or customized. Previous research has been conducted to study the properties of the MSN nanostructures using small-angle X-ray scattering (SAXS) and one of the applications for radioactive drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Rifampicin adsorption and release study using Santa Barbara amorphous-16 modified Al (SBA-16-Al) for a drug delivery system

Prihatiningsih,

Pratama,

Kundari

et al. 2024

RSC Adv.

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The energetic and physical concept of gold nanorod-dependent fluorescence in cancer treatment and development of new photonic compounds|review

Abstract: The optical features of gold nanorods (GNR) may be precisely controlled by manipulating their size, shape, and aspect ratio.

Cited by 6 publications

References 172 publications

Laser-Induced Intracellular Delivery: Exploiting Gold-Coated Spiky Polymeric Nanoparticles and Gold Nanorods under Near-Infrared Pulses for Single-Cell Nano-Photon-Poration

Laser-Induced Intracellular Delivery: Exploiting Gold-Coated Spiky Polymeric Nanoparticles and Gold Nanorods under Near-Infrared Pulses for Single-Cell Nano-Photon-Poration

Surface engineered nanohybrids in plasmonic photothermal therapy for cancer: Regulatory and translational challenges

Rifampicin adsorption and release study using Santa Barbara amorphous-16 modified Al (SBA-16-Al) for a drug delivery system

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