The Endpoint on Measuring the Clinical Effects of Renal Denervation: What Are the Best Surrogates

Sobotka, Paul; Harrison, David G.; Fudim, Marat

doi:10.1007/978-1-4471-5223-1_4

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Ventricular Tachycardia1

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2019

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“…As previously mentioned, RDN was initially developed for the treatment of hypertension and has been shown to reduce global and regional sympathetic nerve activity (117). In a porcine ischemia model, RDN reduced the number of spontaneous ventricular extrasystoles and VF in a similar manner to beta blocker therapy (118).…”

Section: Ventricular Tachycardiamentioning

confidence: 99%

Neuromodulation for the Treatment of Heart Rhythm Disorders

Waldron

Fudim

Mathew

et al. 2019

JACC: Basic to Translational Science

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Highlights Derangement of autonomic nervous signaling is an important contributor to cardiac arrhythmogenesis. Modulation of autonomic nervous signaling holds significant promise for the prevention and treatment of cardiac arrhythmias. Further clinical investigation is necessary to establish the efficacy and safety of autonomic modulatory therapies in reducing cardiac arrhythmias.

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Section: Ventricular Tachycardiamentioning

confidence: 99%