The Endotoxin of the Cholera Vibrio: Immunological Properties.

Types of Acquired Immunity Against Infectious Disease

“…Pathogenicity would appear to be linked rather with the cytoplasmic toxicity of the vibrio, a view which is supported by the observation of . Burrows et al (58) that the loss of virulence in strains which had been employed for the production of enteric infections in guinea pigs was coincident with a decline in the amounts of lipoidal endotoxin (52,53) extractable from the cells.…”

“…Burrows et al (52,53) have obtained from vibrios an endotoxin which is associated with, or is itself, a dialyzable phospholipid, and which is antigenic. Its antibody passively protects mice against bacteria (but not against the toxin itself) but such serum possesses no agglutinating properties for the bacterium.…”

ANTIGENIC RELATIONSHIPS AND TOXICITY OF MUCINOLYTIC PREPARATIONS FROMVIBRIO COMMAAND RELATED VIBRIOS

“…To provide a rational basis for development of more efficient immunization practices, such information on the relation of vibrio products to specific pathology is required. Various kinds of toxic materials from the vibrio cell have been described by Burrows et al (1944aBurrows et al ( , 1944bBurrows et al ( , 1944c), which may be implicated in pathologic processes of cholera, and recent observations focus attention on enzymatic activities of vibrios. Burnet and Stone (1947), Singer et al (1948), Narayanan et al (1953), and Gurkipal et al (1953) have reported that filtrates from vibrio cultures cause sloughing of epithelium from isolated strips of guinea pig ileum, and that this effect is neutralized by specific antiserum.…”