The endothelial nitric oxide synthase −786 T&gt;C polymorphism and the exercise-induced blood pressure and nitric oxide responses among men with elevated blood pressure

Augeri, Amanda L.; Tsongalis, Gregory J.; Heest, Jaci L. Van; Maresh, Carl M.; Thompson, Paul D.; Pescatello, Linda S.

doi:10.1016/j.atherosclerosis.2008.12.015

Cited by 45 publications

(36 citation statements)

References 37 publications

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“…Data et al reported that endurance exercise training lowered forearm vascular resistance and increased forearm blood flow in healthy, young, sedentary women who were carriers of the -786C allele [5]. More recently, Augeri et al [2] found that the -786C allele is associated with blood pressure reductions immediately following low to moderate intensity aerobic exercise. On the other hand, eNOS(-/-) mice had significantly lower oxygen consumption compared with their wild-type counterparts [14].…”

Section: Discussionmentioning

confidence: 95%

“…Notably, the NOS3 -786 T/C polymorphism results in altered transcription and promoter activity [18], and is strongly involved in skeletal muscle glucose uptake during exercise [17]. Studies performed in Spanish and Italian athletes showed that the -786 T allele (which leads to higher gene transcription and promoter activity) is associated with power-oriented athletic status [8,25], whereas another study suggested the -786C allele results in reduced NOS3 gene transcription and promoter activity and is associated with improved aerobic capacity in hypertensive men [2].…”

Section: Introductionmentioning

confidence: 99%

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The C Allele in NOS3 -786 T/C Polymorphism is Associated with Elite Soccer Player's Status

et al. 2012

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The NOS3-786 T/C polymorphism (rs2070744) is a candidate to explain individual variations in sports related phenotypes. We determined the genotype and allele frequency of NOS3-786 T/C in a group of 60 male professional elite soccer players.Their results were compared with those of 100 world-class endurance athletes, 53 elite power athletes, and 100 sedentary, healthy men (controls) of the same Caucasian (Spanish) origin. There were significant differences in genotype frequencies between soccer players, controls, endurance and power elite athletes (all P≤0.02). These results were confirmed when we analysed allelic frequencies (all P<0.01). The likelihood of having the C allele was higher in soccer players compared with (i) controls [odds ratio (OR), 2.165, 95% confidence interval (CI): 1.362-3.441], (ii) endurance athletes (OR:1.879, 95%CI: 1.184-2.984), and (iii) power athletes (OR: 4.032, 95%CI: 2.307-7.047). In conclusion, the -786C allele is associated with the status of being an elite soccer player, compared with non-athletic controls and also with elite endurance and power athletes. More research is needed in other groups of elite soccer players in order to replicate the results of the present study.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

The C Allele in NOS3 -786 T/C Polymorphism is Associated with Elite Soccer Player's Status

et al. 2012

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“…We have shown NOS3 −786 T>C is associated with resting blood pressure (BP) and the BP response to acute bouts of submaximal [5] and maximal aerobic exercise [6]. Others have reported NOS3 −786 T>C to be associated with resting forearm blood flow [7] and the parasympathetic modulation response to aerobic exercise training [8] as well as the differentiation of elite power from endurance athletes [9].…”

Section: Introductionmentioning

confidence: 99%

Endothelial Nitric Oxide Synthase (NOS3) +894 G>T Associates with Physical Activity and Muscle Performance among Young Adults

Guidry

Kostek

Angelopoulos

et al. 2012

ISRN Vascular Medicine

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Objective. We examined the influence of missense polymorphism, endothelial nitric oxide synthase (NOS3) +894 G>T (rs1799983), on habitual physical activity (PA) and the muscle strength response to resistance training (RT). Methods. Men (n = 354) and women (n = 424; 24.3 ± 8.0 yr) were genotyped. Subjects reported hr/wk in vigorous and light intensity PA and sitting on the Paffenbarger PA questionnaire. One repetition maximum assessed muscle strength. Multivariable and repeated measures ANCOVA tested differences among NOS3 +894 G>T and PA and RT phenotypes by gender. Results. hr/wk in vigorous intensity PA (5.4 ± 1.2 versus 8.3 ± 0.4; P = 0.019), more hr/wk in light intensity PA (42.1 ± 2.4 versus 35.8 ± 0.7; P = 0.011), and less hr/wk sitting (37.6 ± 2.8 versus 45.8 ± 0.9; P = 0.006) than those with the G allele. Women with NOS3 +894 TT gained more absolute (4.4 ± 0.3 versus 3.7 ± 0.8 kg; P = 0.013) and relative (78.3 ± 5.8 versus 61.9 ± 1.8%; P = 0.007) strength than those with the G allele. Conclusions. NOS3 +894 G>T associated with PA among men and women and the muscle strength response to RT among women only. Our findings indicate the need for prospective studies examining the influence of NOS3 variants on PA and the muscle response to RT as well as elucidating underlying mechanistic pathways for the associations observed.

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“…The T-786C variant (rs2070744), a thymidine to cytosine transition mutation, is present in the 5' flanking region of eNOS gene and decreases the promoter activity of eNOS, resulting in decrease of endothelial NO production [6]. It was reported that eNOS T-786C variant is related with resting blood pressure [7] and the blood pressure response to acute event of maximal aerobic exercise [8]. The C allele affects eNOS transcription, which is consistent with reduced NO production [9].…”

Section: Introductionmentioning

confidence: 99%

The Endothelial Nitric Oxide Synthase Gene Variant rs2070744 in Turkish Elite Athletes

Cenikli¹

2016

Eu Clin Anal Med

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48.3%, and 11.6% of control subjects and in 55.7%, 30.7% and 13.4% of elite athletes, respectively. There was not any statistically significant difference in genotype and allele frequencies of T-786C of the eNOS between the elite athlete and the control groups (p>0.05). Discussion: The present study demonstrated that the T-786C variant of the eNOS gene is not associated with study population but larger sample analyses are needed in different groups of elite athletes in order to substantiate these findings.

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The endothelial nitric oxide synthase −786 T>C polymorphism and the exercise-induced blood pressure and nitric oxide responses among men with elevated blood pressure

Cited by 45 publications

References 37 publications

The C Allele in NOS3 -786 T/C Polymorphism is Associated with Elite Soccer Player's Status

The C Allele in NOS3 -786 T/C Polymorphism is Associated with Elite Soccer Player's Status

Endothelial Nitric Oxide Synthase (NOS3) +894 G>T Associates with Physical Activity and Muscle Performance among Young Adults

The Endothelial Nitric Oxide Synthase Gene Variant rs2070744 in Turkish Elite Athletes

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