The endothelial hyperplasia of the cerebral blood vessels with brain tumors, and its sarcomatous transformation

Feigin, Irwin; Allen, Lucretia B.; Lipkin, Lewis E.; Gross, Sidney W.

doi:10.1002/1097-0142(195803/04)11:2<264::aid-cncr2820110207>3.0.co;2-d

Cited by 159 publications

(35 citation statements)

References 16 publications

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“…The malignancy-associated properties investigated are general properties exhibited by many neoplastic cell types. Increased plasminogen activator levels associated with brain tumours have previously been reported (Tucker et al, 1978;Hince & Roscoe, 1978) and the endothelial proliferation and neovascularisation associated with central nervous system tumours is well established (Feigin et al, 1958;Gough, 1940;Krylova, 1973 andPena &Feiter, 1973).…”

supporting

confidence: 69%

Interrelationship between differentiation and malignancy-associated properties in glioma

Frame¹,

Freshney²,

Vaughan³

et al. 1984

Br J Cancer

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Summary The phenotypic expression of cells derived from human anaplastic astrocytomas, rat glioma, normal human adult and foetal brain tissue have been examined for differentiated and malignancy-associated properties. Glial fibrillary acidic protein (GFAP), high affinity glutamate and y-amino butyric acid (GABA) uptake and glutamine synthetase were used as indicators of astroglial differentiation. Plasminogen activator and tumour angiogenesis factor were the malignancy-associated markers. The normal adult brain-derived lines showed some differentiated astroglial features and expressed low levels of the malignancy-associated properties. The foetal cultures contained highly differentiated astroglia while the glioma lines showed considerable phenotypic heterogeneity from highly differentiated to undifferentiated. The least differentiated glioma cells exhibited the highest plasminogen activator activities. The density-dependent control of phenotypic expression was also investigated. High affinity GABA uptake, and GFAP in rat C6 glioma cultures, increased with increasing monolayer cell density, events probably mediated by an increase in the formation of cell-cell contacts at confluence. Plasminogen activator activity decreased with increasing cell density.The differences between neoplastic cells and their normal counterparts can usually be described in terms of the repression of specific endogenous genes and the inappropriate expression of others. The observed effect is often the absence of differentiated cell products and the acquisition of properties associated with tumour growth and spread. The objective underlying the present investigation was to determine whether a relationship exists between expression of differentiated properties and malignancy-associated properties in early passage cell cultures derived from anaplastic astrocytomas, normal adult and foetal brain. The successful growth of normal and malignant glial cells provides one of the few model systems with the potential for comparing cytology, biochemistry, immunology and behaviour of malignant and normal cells of similar lineage.Marker properties representing the mature differentiated and malignancy-associated astroglial phenotypes were identified and biological, biochemical or immunological assays used to quantitate their levels of expression. The properties associated with astroglial differentiation are closely concerned with some of the specific functions these cells perform in the brain in vivo and have been identified in glial cells in vitro. These were glial fibrillary acidic protein (GFAP) (Eng et al., 1971),

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confidence: 69%

Interrelationship between differentiation and malignancy-associated properties in glioma

Frame¹,

Freshney²,

Vaughan³

et al. 1984

Br J Cancer

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“…Labeled cells were hypertrophic showing large, plump, elongated or ovoid nuclei that clumped up inside of vascular lumina ( Fig. 2A-D), as described in the literature (32). Importantly, immunoassaying was independent of the presence of infiltrating tumor cells (Figs.…”

Section: Resultsmentioning

confidence: 97%

Assessment of angiogenesis by CD105 and nestin expression in peritumor tissue of glioblastoma

et al. 2010

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Abstract. Angiogenesis in the peritumor tissue of glioblastoma (GBM) is still an open field of research. This study investigates neovascularization in the tumor surrounding areas by examining CD105 and nestin expression along with microvessel density (MVD) with the aim of establishing their possible prognostic significance. Angiogenesis was also confirmed by investigating, in vessel walls, the presence of pericytes, which are multipotent stem cells, expressing ·-smooth muscle actin (·-SMA). In our study, including 40 GBM patients, tissue samples were obtained from tumors (first area) and white matter at a distance <1 cm (second area) and between 1 and 3.5 cm (third area) from the tumor margin. CD105 and nestin were detected by immunohistochemistry in hyperplastic endothelium of GBM and peritumor tissue, and occasionally coexpressed or colocalized. Pericytes encircling hyperplastic endothelium were evident in all three areas. Univariate analysis revealed that patients with a CD105-MVD value ≥8 in the third area have a significantly shorter survival time and Cox analysis indicated an about 3.5-fold increase in death risk in the same patients. These results demonstrate that a tumor neoangiogenesis occurs in GBM peritumor tissue with intimate involvement of pericytes. CD105-MVD in the area located at a greater distance from the tumor margin carries prognostic significance.

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“…Feigin et al, who defined the sarcomatous component as a proliferation of glioblastoma blood vessels, first assessed it 2 . However, immunohistochemical studies have failed to detect endothelial markers in the sarcomatous component 6,12,13 .…”

mentioning

confidence: 86%

Gliosarcoma: report of four cases with immunohistochemical findings

Machuca

Prevedello

Pope

et al. 2004

Arq. Neuro-Psiquiatr.

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-Gliosarcoma (GSa) is a rare primary central nervous system neoplasm (CNS) characterized by biphasic histological pattern with both glial and sarcomatous components. Our objective is to describe the clinical, morphological and immunohistochemical features of four cases of GSa and to discuss its pathogenetic mechanisms. The male:female ratio was 3:1. The mean age was 39 years, ranging from 19 to 48. Headache was the commonest clinical symptom. All patients underwent craniotomy with microsurgery and total resection of the tumor. Diagnosis was suspected due to microscopic architecture and confirmed by detection of reticulin fibers through histochemical techniques. Immunohistochemical analysis was positive for p53 in both glial and sarcomatous cells in all four cases. EGFR was focally positive in glial cells in one case. Our findings support monoclonal origin of GSa involving the TP53 tumor-suppressor gene. However, alternative pathways cannot be ruled out.KEY WORDS: brain neoplasms, gliosarcoma, immunohistochemistry. Gliossarcoma: relato de quatro casos com achados imuno-histoquímicosRESUMO -Gliossarcoma (GSa) é uma neoplasia primária rara do sistema nervoso central, caracterizada por padrão histológico bifásico incluindo componentes tanto glial como sarcomatoso. São discutidos os aspectos clínicos, morfológicos e imunohistoquímicos de quatro casos de GSa e seus mecanismos patogêneticos. A relação masculino/feminino foi 3:1. A média de idade foi 39 anos, variando de 19 a 48. Cefaléia foi a manifestação predominante. Todos os pacientes foram submetidos a craniotomia com microcirurgia e ressecção total do tumor. O diagnostico foi suspeitado devido à arquitetura microscópica e foi confirmada por presença de fibras de reticulina através de técnicas de histoquímica. A análise imuno-histoquímica foi positiva para p53 tanto em células gliais como em células sarcomatosas nos quatro casos. EGFR foi localmente positivo em células gliais em apenas um caso. Esses achados apoiam uma origem monoclonal do GSa relacionada com alteração no Tp53, gene supressor de tumor. No entanto, outras vias alternativas na gênese desses tumores não podem ser afastadas. PALAVRAS-CHAVE: neoplasias cerebrais, gliossarcoma, imuno-histoquímica.genetic studies failed to support this theory, suggesting a monoclonal origin for both histological components 1 . GSa corresponds to less than 2% of all glioblastomas 1 , with a peak of incidence from the fourth to the sixth decades of life, mean age 53 years. Male: female ratio is 1.8:1 and the clinical presentation, natural history and radiologic profile are similar to those of primary glioblastoma 1,3 . We studied four cases of gliosarcoma aiming to

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The endothelial hyperplasia of the cerebral blood vessels with brain tumors, and its sarcomatous transformation

Cited by 159 publications

References 16 publications

Interrelationship between differentiation and malignancy-associated properties in glioma

Interrelationship between differentiation and malignancy-associated properties in glioma

Assessment of angiogenesis by CD105 and nestin expression in peritumor tissue of glioblastoma

Gliosarcoma: report of four cases with immunohistochemical findings

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