The Endothelial Frontier

Wolburg, Hartwig

doi:10.1002/9783527611225.ch4

Cited by 7 publications

(6 citation statements)

References 216 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reason for this mutual exclusiveness is not clear and biochemically and functionally unknown, except that both structures are involved in the regulation of liquid Xow. Since OAPs are now known to contain aquaporin-4 (AQP4; for a review, see, for example, Wolburg 2006), it seemed probable that OECs would not express AQP4. This expectation was conWrmed in this study (Fig.…”

Section: Axonal Growth and Vascular Permeabilitymentioning

confidence: 99%

Epithelial and endothelial barriers in the olfactory region of the nasal cavity of the rat

Wolburg

Wolburg‐Buchholz

Sam

et al. 2008

Histochem Cell Biol

Self Cite

View full text Add to dashboard Cite

The olfactory ensheathing (glial) cells (OECs) have been identified to be useful candidate cells to support regeneration after being transplanted into injured fiber tracts of the central nervous system. We investigated by means of immunocytochemistry and freeze-fracturing the morphology and molecular composition of OEC tight junctions in the rat olfactory system. In addition, we tested the hypothesis whether tight junctions and orthogonal arrays of particles (OAPs) which contain the water channel protein aquaporin-4 (AQP4), are mutually exclusive as suggested in previous studies. In OECs, we found neither OAPs nor AQP4, but tight junctions immunoreactive for ZO-1, occludin, and claudin-5, but immunonegative for ZO-2 and claudin-3. To shed more light on the function of OEC tight junctions, we tested the permeability and tight junction composition of blood vessels and fila olfactoria. We found them both, permeable for infused lanthanum nitrate, and to be immunopositive for ZO-1 and claudin-5. The tight junctions of the OECs are discussed to be responsible for micro-compartmentalization within the olfactory fiber tract providing a benefit for axonal growth.

show abstract

Section: Axonal Growth and Vascular Permeabilitymentioning

confidence: 99%

Epithelial and endothelial barriers in the olfactory region of the nasal cavity of the rat

Wolburg

Wolburg‐Buchholz

Sam

et al. 2008

Histochem Cell Biol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Molecules such as albumin and insulin are known to undergo endothelial transcytosis in peripheral tissue, perhaps through different subsets of caveolae [64]. Caveolar membranes contain receptors for transferring, insulin, albumin, ceruloplasmin, RAGE, LDL, HDL, IL-1 and vesicle-associated membrane protein-2 [15].…”

Section: Receptor Mediated Transportmentioning

confidence: 99%

“…The molecular biology of TJs is quite complex [15], and their proteins, as well as their adaptor molecules, which link TJs to the cytoskeleton, are often affected during acute or chronic brain disease. Figure 2 shows the molecular organization of BBB TJs, critical determinants of BBB restrictiveness.…”

Section: Bbb Structurementioning

confidence: 99%

Cellular Elements of the Blood-Brain Barrier

2009

View full text Add to dashboard Cite

The Blood-brain-barrier (BBB) provides both anatomical and physiological protection for the central nervous system (CNS), shielding the brain for toxic substances in the blood, supplying brain tissues with nutrients and filtering harmful compounds from the brain back to the bloodstream. The BBB is composed of four main cellular elements: endothelial cells (ECs), astrocyte end-feet, microglial cells, and pericytes. Transport across the BBB is limited by both physical and metabolic barriers (enzymes, and different transport systems). Tight junctions (TJs) present between ECs form an important barrier against diffusion, excluding most blood-borne substances for entering the brain.

show abstract

“…69 α-, β-, and γ-catenin proteins link these proteins to the actin/vinculin-based cytoskeleton. 70 In the CNS, Occludin 69 and Claudins 1, 71 3, 5, and 12 72,73 interact to form tight junctions. The BBB's exclusivity to different molecular size is differentially regulated by particular Claudins.…”

Section: Specifically Junctional Adhesion Molecules A-c (Jam A-c) Pla...mentioning

confidence: 99%

The emergence of the calvarial hematopoietic niche in health and disease

Mills

Coburn

Eyo

2022

Immunological Reviews

View full text Add to dashboard Cite

Summary The diploë region of skull has recently been discovered to act as a myeloid cell reservoir to the underlying meninges. The presence of ossified vascular channels traversing the inner skull of cortex provides a passageway for the cells to traffic from the niche, and CNS‐derived antigens traveling through cerebrospinal fluid in a perivascular manner reaches the niche to signal myeloid cell egress. This review will highlight the recent findings establishing this burgeoning field along with the known role this niche plays in CNS aging and disease. It will further highlight the anatomical routes and physiological properties of the vascular structures these cells use for trafficking, spanning from skull to brain parenchyma.

show abstract

The Endothelial Frontier

Cited by 7 publications

References 216 publications

Epithelial and endothelial barriers in the olfactory region of the nasal cavity of the rat

Epithelial and endothelial barriers in the olfactory region of the nasal cavity of the rat

Cellular Elements of the Blood-Brain Barrier

The emergence of the calvarial hematopoietic niche in health and disease

Contact Info

Product

Resources

About