The Endoscopic Demonstration of Coeliac Disease

Stevens, F. M.; McCarthy, C. F.

doi:10.1055/s-0028-1098406

Cited by 59 publications

(22 citation statements)

References 3 publications

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“…STEVENS and McCARTHY (18) reported that severe atrophy of the mucosal surface could be demonstrated throughout the duodenal cap using indigo carmine scattering with an Olympus GIF type D2 endoscope.…”

Section: Discussionmentioning

confidence: 99%

Magnifying endoscopy of the duodenum with dye scattering method in a case with celiac disease

Morishita

Kamiya²,

Ishii

2003

Arq. Gastroenterol.

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-Aim -To know the more detailed findings of the small intestinal mucosa with the use of a magnifying endoscope and a vital dye, and the efficacy of the both tools. Patient and Methods -A 54-year old female patient with celiac disease. The duodenal mucosa downward as far as the descending portion was observed with a magnifying endoscope (Olympus GIF HM) before and after spraying the mucosa with 0.1% indigo carmine. Results -The endoscopy clarified the atrophy and edema of each villus, and scattering of the dye revealed shorter villi with the relatively longer villi remaining in islands. Conclusion -The combination of magnifying endoscopy and the dye scattering method is useful for closer observation of the intestinal mucosa in celiac diseases.

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Section: Discussionmentioning

confidence: 99%

Magnifying endoscopy of the duodenum with dye scattering method in a case with celiac disease

Morishita

Kamiya²,

Ishii

2003

Arq. Gastroenterol.

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“…Before starting the study, the operators met to formally define, with the aid of endoscopic images, the endoscopic signs that were to be looked for in both adult [9,10,11,12] and pediatric patients [13,14]. These signs consisted of (1) mosaic pattern of the duodenal mucosa, (2) reduction or loss of the duodenal (Kerckring's) folds, (3) scalloping of the valvulae conniventes and (4) a nodular pattern of the bulbar mucosa (fig.…”

Section: Methodsmentioning

confidence: 99%

The Importance of Disease Prevalence in Assessing the Diagnostic Value of a Test: Endoscopic Markers in Celiac Disease

Pellegrino

Furfaro

Tortora³

et al. 2013

Digestion

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Background/Aims: We evaluated the diagnostic variability and reproducibility of endoscopic signs in two populations with a different pretest likelihood of celiac disease (CD). Methods: We recruited 289 CD patients (both adults and children) in a multicenter prospective study. Group 1 (high risk) included 111 patients referred for positive serology. Group 2 (low risk) included 178 unselected patients. Mosaic pattern, reduction/loss of Kerckring's folds, scalloping of the valvulae conniventes and a nodular pattern were the endoscopic findings looked for in the duodenum. Results: In group 1, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of endoscopic findings were 100, 84.6, 94.2 and 100% in adults, and 86.8, 9.1, 82.1 and 12.5% in children. In group 2, the sensitivity, specificity, PPV and NPV of endoscopic findings were 33.3, 91.4, 7.7 and 98.5% in adults, and noncalculable, 78.3, 0.0 and 100% in children. Comparing group 1 and group 2, there was a statistically significant difference in sensitivity and PPV in adults, and in specificity, PPV and NPV in children. Concerning the reproducibility of endoscopic findings, a wide variability of κ values was found. Conclusion: Endoscopic signs have low reproducibility for CD, and their diagnostic value in selecting patients for multiple intestinal biopsies is unacceptable, especially in populations with low disease prevalence.

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“…Reduced duodenal folds, scalloping of fold margins, mosaic pattern of mucosa and grooves in the mucosa are usual conventional endoscopic signs for celiac disease [50][51][52][53][54] . However these findings are not reliable in patchy [55,56] or milder cases of subtotal atrophy [57] .…”

Section: Celiac Diseasementioning

confidence: 99%

Narrow band imaging with magnification for the diagnosis of lesions in the upper gastrointestinal tract

Singh

Hussain

Loong

2013

WJGE

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Endoscopy plays an important role in the diagnosis and management of gastrointestinal (GI) tract disorders. Chromoendoscopy has proven to be superior to white light endoscopy for early detection of various GI lesions. This has however been fraught with problems. The use of color stains, time taken to achieve an effect and the learning curve associated with the technique has been some of the pitfalls. Narrow band imaging (NBI) particularly in combination with magnifying endoscopy may allow the endoscopist to accomplish a fairly accurate diagnosis with good histological correlation similar to results achieved with chromoendoscopy. Such enhanced detection of pre-malignant and early neoplastic lesions in the gastrointestinal tract should allow better targeting of biopsies and could ultimately prove to be cost effective. Various studies have been done demonstrating the utility of this novel technology. This article will review the impact of NBI in the diagnosis of upper gastrointestinal tract disorders.

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The Endoscopic Demonstration of Coeliac Disease

Cited by 59 publications

References 3 publications

Magnifying endoscopy of the duodenum with dye scattering method in a case with celiac disease

Magnifying endoscopy of the duodenum with dye scattering method in a case with celiac disease

The Importance of Disease Prevalence in Assessing the Diagnostic Value of a Test: Endoscopic Markers in Celiac Disease

Narrow band imaging with magnification for the diagnosis of lesions in the upper gastrointestinal tract

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