Endodontic treatments during pregnancy can be safely performed taking certain precautions. The aim of this clinical case, which we present in our article, was to treat an irreversible pulpitis in a second-trimester pregnancy patient who was undergoing an orthodontic treatment prior to pregnancy. The endodontic treatment was performed without removing the facial arch and brackets, in a single session, using multiple waves condensation method. The endodontic technique of vertical hot condensation used has the advantage that it can fill the entire root system three-dimensionally. After one week, the coronal restoration was made with resin composites. Teeth that are included in an orthodontic treatment can be adequately endodontically treated and coronally restored during pregnancy.