The Endocrinologic Changes in Critically Ill Chronic Obstructive Pulmonary Disease Patients

Akbaş, Türkay; Karakurt, Sait; Ünlügüzel, Göksenin; Celikel, Turgay; Akalın, Sema

doi:10.3109/15412555.2010.496815

Cited by 17 publications

(19 citation statements)

References 51 publications

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“…As demonstrated in our patients, LH and FSH levels decrease in severely ill women [4,6,9,14]. The decrease was not dependent on disease type, patient's age, and medications used [5,14].…”

Section: Discussionmentioning

confidence: 59%

“…In the chronic phase, T decreases further and gonadotropins are measured low, supporting hypothalamic-pituitary dysfunction [7,8]. Similar alterations in LH and FSH values are encountered in women [4,6,9,10].…”

Section: Introductionmentioning

confidence: 55%

“…In our patients, discharged female patients had a significant increase in FSH levels. Since LH is more severely affected than FSH, the rise in FSH occurs first during recovery [6,20]. Return of gonadotropins to normal limits was reported to take months, even years in some patients [6,9,10].…”

Section: Discussionmentioning

confidence: 99%

“…Testosterone (T) levels decrease during the early phase and the secretions of luteinising hormone (LH) and follicle stimulating hormone (FSH) are generally increased to attenuate T concentration [4,5]. However, normal or low LH and FSH levels can sometimes be observed even though the simultaneous T level is low [5,6]. In the chronic phase, T decreases further and gonadotropins are measured low, supporting hypothalamic-pituitary dysfunction [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…LH, FSH, T, TSH, fT 3 , and fT 4 were measured by the electrochemiluminescence immunoassay "ECLIA" method (Modular Analytics E170, Roche, America), PRL by the ECLIA method (Elecsys 2010, Roche, America), C-Reactive protein (CRP) by particleenhanced immunoturbidimetric assay (Hitachi 917, Roche, America), and estradiol (E 2 ) and cortisol by chemiluminescent enzyme immunoassay (Immulite 2000, Roche, America), as described elsewhere [6]. The intra-assay coefficient of variation for cortisol was 5.2% at 8.5 µg/dL and 6.2% at 26 µg/dL.…”

Section: Assaysmentioning

confidence: 99%

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The pıtuıtary-gonadal-thyroıd and lactotroph axes ın crıtıcally ıll patıents

Akbaş

Deyneli

Sönmez

et al. 2015

Endokrynologia Polska

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Introduction: The normal circadian rhythm of hormones in critical patients becomes chaotic causing some hormones to increase and others to decrease abnormally. The goal of this study is to evaluate hormonal changes in severely ill patients and to investigate the relationship between hormonal changes and mortality and morbidity. Material and methods: We enrolled 20 patients (10 F/10 M). Blood samples were collected on day 0, day 5, and day 10. If a patient was discharged before these defined days, a sample was drawn on that day. Twenty healthy controls were included. Results: Female patients had lower LH, FSH, and fT 3 and higher PRL and cortisol levels than controls on admission to the intensive care unit (ICU) (p LH = 0.021, p FSH :0.001, p fT3 = 0.021, p PRL = 0.042, p Cortisol < 0.001, respectively). Men had significantly low testosterone and fT 3 , and high PRL and cortisol levels on ICU admission (p T = 0.01, p fT3 = 0.043, p PRL = 0.005, p Cortisol < 0.001, respectively). The lowest levels of gonadotropins in both genders and testosterone in men were measured on day 5. Cortisol levels decreased in the patients discharged from the ICU (p = 0.01). FSH levels increased in recovered women (p FSH = 0.043). The mortality rate was 30%. There were correlations between admission TSH and NIMV duration (p = 0.006), fT 3 and APACHE II (p = 0.001), and PRL and mortality (p = 0.044). Positive correlations between E 2 and APACHE II (p = 0.003) in females, and PRL and APACHE II (p = 0.022) in males were also displayed.

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“…As demonstrated in our patients, LH and FSH levels decrease in severely ill women [4,6,9,14]. The decrease was not dependent on disease type, patient's age, and medications used [5,14].…”

Section: Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Assaysmentioning

confidence: 99%

See 3 more Smart Citations

The pıtuıtary-gonadal-thyroıd and lactotroph axes ın crıtıcally ıll patıents

Akbaş

Deyneli

Sönmez

et al. 2015

Endokrynologia Polska

Self Cite

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Hypogonadism in Systemic Diseases

Rochira

2017

Endocrinology

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Serum testosterone is often lower than normal in patients with acute or chronic systemic diseases. The underlying mechanisms involved in the reduced testosterone secretion depend on the type of systemic disease; thus, many pathogenetic mechanisms might be involved. These mechanisms involve the hypothalamus and the pituitary (secondary hypogonadism), the testis (primary hypogonadism), or both. The resulting low-serum testosterone could be reversible or not depending on the pathogenetic mechanism. Furthermore, the relationships between hypogonadism and the systemic disease are complex since these two clinical conditions may interact with each other in a bidirectional interplay. How to interpret low-serum testosterone in systemic diseases is not easy and univocal. Biochemical hypogonadism should be differentiated into overt clinical hypogonadism and functional hypogonadism, and testosterone treatment should be offered taking into account the primary systemic disease and the possible beneficial or harmful effect on it, as well as the presence of signs and symptoms of hypogonadism. In this chapter the main systemic illnesses associated with hypogonadism will be discussed together with their underlying pathogenetic mechanisms, clinical significance, relevance, and clinical and practical implications

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Hypogonadism in Systemic Diseases

Rochira

2017

Endocrinology

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The Endocrinologic Changes in Critically Ill Chronic Obstructive Pulmonary Disease Patients

Abstract: Men and women with acute respiratory failure in the presence of COPD develop significant changes in the neuroendocrine axis. Hormonal suppression vanishes with disease improvement.

Cited by 17 publications

References 51 publications

The pıtuıtary-gonadal-thyroıd and lactotroph axes ın crıtıcally ıll patıents

The pıtuıtary-gonadal-thyroıd and lactotroph axes ın crıtıcally ıll patıents

Hypogonadism in Systemic Diseases

Hypogonadism in Systemic Diseases

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