The Endocrine Spectrum of Arachnoid Cysts in Childhood

Mohn, Angelika; Schoof, Ellen; Fahlbusch, R.; Wenzel, D.; Dörr, H. G.

doi:10.1159/000028882

Cited by 40 publications

(48 citation statements)

References 19 publications

(18 reference statements)

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“…In those patients, the possibility that the hGH treatment could have influenced the early onset of puberty is unknown (27). This rare combination of GHD and CPP has been reported essentially in patients with septo-optic dysplasia (6-10) and arachnoid cyst (2)(3)(4)(5). It has also exceptionally been described after a head trauma (7,12).…”

Section: Discussionmentioning

confidence: 99%

“…However, GHD has been reported to be associated with CPP in cases of arachnoid cyst (2)(3)(4)(5), septo-optic dysplasia (6-10), brain tumors in the pituitary region, or after cerebral radiation therapy, particularly if administered as prophylaxis against acute lymphoblastic leukemia (11)(12)(13). This association has also been reported in very rare cases after a head injury (7,13).…”

Section: Introductionmentioning

confidence: 98%

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GH deficiency with central precocious puberty: a new rare disorder associated with a developmental defect of the hypothalamic–pituitary area

Ladjouze¹,

Soskin²,

Garel³

et al. 2007

eur j endocrinol

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Context: GH deficiency (GHD) associated with central precocious puberty (CPP) has been widely reported in cases of arachnoid cyst, septo-optic dysplasia, brain tumors, or after cerebral radiation therapy. However, idiopathic GHD associated with CPP has been reported in only one isolated case. Objective: To evaluate the occurrence and clinical features of the association of nonacquired GHD and CPP. Design and setting: This was a retrospective multicenter study. Patients and methods: The study population was identified through a French nationwide multicenter network (about 3000 patients). We reviewed the medical records of all subjects diagnosed with nonacquired GHD and CPP, with or without developmental abnormalities of the hypothalamic-pituitary axis on cerebral magnetic resonance imaging (MRI), and without any known associated anomaly. Results: We identified four patients with either isolated GHD (nZ1) or multiple anterior pituitary hormone deficiencies (nZ3). Clinical signs of CPP occurred at 6.4G2.3 years in boys and 7.5G0.5 years in girls, and GnRH analog therapy was started at 4.2G1.6 years after the initiation of recombinant human GH treatment. Cerebral MRI demonstrated ectopic neurohypophysis associated with anterior pituitary hypoplasia in three out of the four patients. The morphology and position of the anterior pituitary and neurohypophysis were normal in one patient who displayed a persistence of the craniopharyngeal canal. Conclusions: CPP is very rare in patients with nonacquired GHD and is mostly associated with developmental defects in the hypothalamic-pituitary area. Whether molecular mechanisms governing development and activation of the hypothalamic-pituitary axis share dependent factors remains to be explored.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

GH deficiency with central precocious puberty: a new rare disorder associated with a developmental defect of the hypothalamic–pituitary area

Ladjouze¹,

Soskin²,

Garel³

et al. 2007

eur j endocrinol

View full text Add to dashboard Cite

show abstract

“…Precocious puberty, growth hormone deficiency, visual impairment (including blindness), ataxia, head bobbing, and tremor may result when the cyst compresses the adjacent brain. Most suprasellar arachnoid cysts are diagnosed after they have caused symptoms in childhood, 3,4 and very few cases have been diagnosed prenatally before the onset of manifestations. Pierre-Kahn et al 3 reported that out of 20 suprasellar arachnoid cysts studied, 60% were associated with endocrine disorders.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the disorders never regressed postoperatively, even when the decrease of the cyst volume was satisfactory. 3 Mohn et al 4 reported that most pediatric arachnoid cysts have growth hormone deficiency and require hormone replacement therapy even after surgery. In our case, there was a high probability that the child would also have experienced significant complications.…”

Section: Discussionmentioning

confidence: 99%

Management of a suprasellar arachnoid cyst identified using prenatal sonography

Fujimura¹,

Shima²,

Arai³

et al. 2006

J of Clinical Ultrasound

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We present a rare case of suprasellar arachnoid cyst discovered incidentally on routine fetal sonographic examination. Serial sonographic and MRI scanning led to a prenatal diagnosis and appropriate endoscopic treatment at 5 months of age. The patient is currently developing normally at 3 years of age. Careful screening of fetal intracranial abnormalities is important in routine prenatal sonographic examination for early intervention, which will prevent irreversible complications such as endocrine disorders and visual impairment.

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“…Opponents of conservative therapy point to the risk of hemorrhage and the potential for impaired CNS development. Supporting the case for intervention, Mohn et al [43]reported that children with arachnoid cysts had a greatly increased incidence of endocrine dysfunction. Such dysfunction could be slowly progressive, developing over years [34, 43], and was more frequently associated with suprasellar location [43].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Resolution of a Prepontine Arachnoid Cyst

Dodd

Barnes

Huhn³

2002

Pediatr Neurosurg

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Prepontine arachnoid cysts are rare developmental anomalies that occur almost exclusively in children. The symptomatic child typically suffers from hydrocephalus, visual impairment, endocrine dysfunction and/or cranial neuropathies. Some cysts, however, are discovered incidentally upon prenatal or postnatal imaging for other indications. While there is little doubt that surgical treatment should be initiated to help the symptomatic child, appropriate therapy for the asymptomatic patient is unclear. Although arachnoid cysts are often managed conservatively using serial imaging, the consequences of injury to surrounding structures with prepontine cysts often lowers the threshold for intervention. The natural history of asymptomatic prepontine arachnoid cysts is unknown. It has been reported that some cysts enlarge and cause symptoms, whereas others are stable for years. This report describes an index case of spontaneous resolution of a prepontine arachnoid cyst in a female infant over a 5-year period.

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The Endocrine Spectrum of Arachnoid Cysts in Childhood

Cited by 40 publications

References 19 publications

GH deficiency with central precocious puberty: a new rare disorder associated with a developmental defect of the hypothalamic–pituitary area

GH deficiency with central precocious puberty: a new rare disorder associated with a developmental defect of the hypothalamic–pituitary area

Management of a suprasellar arachnoid cyst identified using prenatal sonography

Spontaneous Resolution of a Prepontine Arachnoid Cyst

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