The Endocrine Pancreas in Brain-Dead Donors a Prospective Study in 25 Patients

Masson, F.; Thicoïpé, M.; Gin, H.; Mascarel, A. De; Angibeau, R; Favarel-Garrigues, Jean-Claude; Erny, P.

doi:10.1097/00007890-199308000-00022

Cited by 74 publications

(45 citation statements)

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“…The vasculature of the spleen was ligated; the pancreas was dissected from the greater omentum, exteriorized and fixed on a plastic pad (Histoacryl Blue, Braun). To keep the temperature of the exteriorized pancreas constant (35)(36)(37)(38) • C), the pancreas was superfused with warm saline. To monitor pancreatic tail temperature, a temperature-sensitive probe (Licox, GMS) was placed between the pancreas and the plastic pad.…”

Section: Surgical Proceduresmentioning

confidence: 99%

Brain Death Impairs Pancreatic Microcirculation

Obermaier

Dobschuetz

Keck

et al. 2004

American Journal of Transplantation

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Brain death (BD) influences the quality of donor grafts in transplantation. To evaluate the impact of BD on pancreas grafts, we investigated the influence of BD on the microcirculation and histology of the pancreas in a rat model of explosive BD. A group of Wistar rats (n = = 7), rendered brain dead by inflating an intracranially inserted Fogarty catheter was compared with controls (CO) using intravital epifluorescence-microscopy over 4 h after BD induction; functional capillary density (FCD), leukocyte adherence (AL) in post-capillary venules, histology and pancreatic enzymes were investigated. Four hours after BD, FCD decreased (333 ± 11 vs. baseline 444 cm/cm 2 ± 5 SEM; p < 0.01) and showed lower values than CO (388 ± 9 p < 0.01). In BD, AL was increased (628 cells/mm 2 ± 110 SEM vs. baseline 123 ± 32, and vs. CO 180 ± 33; p < 0.001). BD caused increased histological damage (CO 1.6 scorepoints ± 0.7 SD vs. BD 8.3 ± 7.1; p < 0.05). Amylase was higher in BD (p < 0.05) but did not reach pathological values. We show for the first time that BD causes relevant changes in pancreatic microcirculation, histology and leukocyte endothelial interaction which might have a serious impact on the function of grafts. New strategies for preventing this damage are therefore highly desirable in order to improve the outcome of pancreas transplantation.

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Section: Surgical Proceduresmentioning

confidence: 99%

Brain Death Impairs Pancreatic Microcirculation

Obermaier

Dobschuetz

Keck

et al. 2004

American Journal of Transplantation

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“…La hiperglicemia es frecuente y multifactorial: secundaria al estrés, al aumento de los niveles de hormonas contrarreguladoras, al uso concomitante de esteroides, cambios en el metabolismo de carbohidratos, infusión de soluciones que contienen glucosa, y resistencia periférica a la insulina 1,6,71,72 . Algunos autores han mostrado una asociación entre hiperglicemia y disfunción renal post-trasplante 73 .…”

Section: Manejo Endocrinológico Del Potencial Donante Cadáverunclassified

Manejo del potencial donante cadáver

et al. 2014

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“…67,68 Working together, these agents serve to dramatically increase gluconeogenesis and insulin resistance, impair release of insulin from the pancreas, and result in marked hyperglycemia. 69 In addition, the diabetes insipidus that occurs as the result of brain swelling results in significant free-water loss and leads to hypernatremia. 66,[70][71][72] Severe hypernatremia has been associated with worse outcomes after liver transplantation.…”

Section: Hyperglycemia In Potential Deceased Organ Donorsmentioning

confidence: 99%

Glycemic Control and Organ Transplantation

Marvin

Morton²

2009

J Diabetes Sci Technol

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A discussion of hyperglycemia during organ transplantation is a broad topic that includes patients with a known history of diabetes pretransplant, those at risk for post-transplant diabetes, those with stress-induced hyperglycemia, those with hyperglycemia related to immunosuppressive therapy, and hyperglycemia in the deceased organ donor. In contrast to the plethora of articles and studies describing perioperative and critical care management of hyperglycemia in cardiac, trauma, and medical/surgical intensive care unit patients, relatively few published articles in the field of organ transplantation can be found. This article consists of a review of available literature in the form of publications and abstracts, and a preliminary report of the authors' work with liver transplantation and deceased organ donors.

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The Endocrine Pancreas in Brain-Dead Donors a Prospective Study in 25 Patients

Cited by 74 publications

References 0 publications

Brain Death Impairs Pancreatic Microcirculation

Brain Death Impairs Pancreatic Microcirculation

Manejo del potencial donante cadáver

Glycemic Control and Organ Transplantation

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