The endocrine dependency of certain thyroid cancers and the danger that hypothyroidism may stimulate their growth

Crile, George

doi:10.1002/1097-0142(195711/12)10:6<1119::aid-cncr2820100607>3.0.co;2-m

Cited by 105 publications

(33 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The aim of this study was to investigate somatostatin binding in human gastrointestinal cancer and normal mucosa. Plasma membranes were prepared from specimens of tumour and normal mucosa from 51 patients undergoing surgical resection for malignancy (28 gastric, 23 (Horowitz et al, 1975;Higgins et al, 1941;Crile, 1957;Osei et al, 1985). There is, however, no currently defined role for endocrine therapy in non-endocrine gastrointestinal cancer.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Somatostatin binding in normal and malignant human gastrointestinal mucosa

Miller

Farmery²,

Woodhouse³

et al. 1992

Br J Cancer

View full text Add to dashboard Cite

Summary Somatostatin is a regulatory peptide implicated in the control of cellular proliferation in epithelial tissues and this regulation may occur directly via membrane bound receptor activation. The aim of this study was to investigate somatostatin binding in human gastrointestinal cancer and normal mucosa. Plasma membranes were prepared from specimens of tumour and normal mucosa from 51 patients undergoing surgical resection for malignancy (28 gastric, 23 (Horowitz et al., 1975;Higgins et al., 1941;Crile, 1957;Osei et al., 1985). There is, however, no currently defined role for endocrine therapy in non-endocrine gastrointestinal cancer. Surgical intervention is the most effective treatment for this condition and, even then, can only afford a 'cure' in early disease. Advanced tumours are associated with a poor prognosis, marginally improved by chemotherapeutic regimens. Any benefit from systemic therapy is usually abrogated by systemic toxicity (Rake et al., 1979;Engstrom et al., 1985;Bleiberg, 1990). For this reason a non-toxic, effective, treatment modality would be of value to improve the outlook for those patients with advanced disease.There is increasing evidence that tumours arising from the gastrointestinal tract are, at least in part, hormone dependent. Numerous hormones have now been implicated in the pathogenesis and development of gastrointestinal malignancy, including gastrin, epidermal growth factor, enteropancreatic hormones and oestrogenic steroids (Sirinek et al., 1985;Watson et al., 1988;Li et al., 1980;Howatson & Carter, 1985;McMichael et al., 1980). These findings, together with the observation that transformed gut epithelial cells may retain functional hormone receptors , have suggested a role for hormonal manipulation in these malignancies.Somatostatin and its analogues are good candidates for use as endocrine agents in the treatment of gastrointestinal cancer. The native peptide is widely distributed in the body and, amongst its many inhibitory actions, has a putative role as an anti-proliferative agent in both normal (Lehy et al., 1979) and malignant tissue. The mechanisms involved in this anti-proliferative action have not, as yet, been confirmed. Both the native peptide and its analogues act at the somatotrophs of the anterior pituitary suppressing growth hormone production and release (Adrian et al., 1981). This may influence the proliferation of target tissues directly or may result in a substantial reduction in local growth factor release (Kirkegaard et al., 1984 (Reubi et al., 1987a;Reubi et al., 1987b;Reubi et al., 1990;Ikuyama et al., 1985). Somatostatin (1981). In brief, frozen tumour and mucosal samples were mechanically pulverised and homogenised on ice in homogenising buffer (sucrose 250 mM, KCI 25 mM and MgCl2 10 mM in Tris-HCI 50 mM; pH 7.4) at 10,000 r.p.m. in short bursts for 2 min using an Ultraturrax T25 homogeniser (Scientific

show abstract

mentioning

confidence: 99%

“…Hormonal manipulation, by surgical or medical methods, has been used extensively in therapy for carcinoma of the breast, prostate, thyroid and in certain gut endocrine tumours (Horowitz et al, 1975;Higgins et al, 1941;Crile, 1957;Osei et al, 1985). There is, however, no currently defined role for endocrine therapy in non-endocrine gastrointestinal cancer.…”

mentioning

confidence: 99%

Somatostatin binding in normal and malignant human gastrointestinal mucosa

Miller

Farmery²,

Woodhouse³

et al. 1992

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…[2][3][4]9 Our patient demonstrated neurological symptoms 12 days after the operation (removal of the remnant thyroid gland, i.e., total thyroidectomy) even though he did not receive thyroid hormone replacement. This correlates with the statement reported by Crile 11 that the function and the growth of metastatic thyroid tumors could be stimulated by TSH. Although EEG has not previously been reported to be useful for the detection of the brain metastases, in our patient EEG was of use in detecting the brain lesion.…”

Section: Discussionmentioning

confidence: 99%

Solitary Brain Metastasis from Papillary Thyroid Carcinoma in a Patient with Depression: Report of a Case

Maruyama

Kobayashi²,

Shingu³

et al. 2000

Surgery Today

View full text Add to dashboard Cite

Papillary carcinoma of the thyroid is a common thyroid malignancy with a relatively good prognosis. However, distant metastases may develop and become threatening, particularly to older patients, in a more aggressive manner. We report herein the clinical, radiological, and pathological findings of a patient with papillary thyroid carcinoma who had a solitary cerebral metastasis. The patient had been suffering from depression and had already undergone a hemithyroidectomy for primary thyroid carcinoma, and was known to have metastatic thyroid carcinoma of the lungs and bone. After the removal of the remnant thyroid gland prior to radioiodine (131I) therapy, he developed additional problems related to depression. Electroencephalography played an important role in identifying suspected brain metastasis and computed tomography demonstrated a space-occupying lesion in the left cerebral hemisphere. Consequently, an early removal of intracranial mass could be performed without any further life-threatening complications. Moreover, after removal of the brain mass the patient's depression improved immediately without the use of any antidepressants. This case report indicates the possibility that a patient's depression might be associated with brain metastasis from papillary thyroid carcinoma, and also suggests that an early diagnosis with the appropriate surgical management of a brain metastasis followed by radioiodine therapy could be valuable for achieving a prolonged disease-free period.

show abstract

“…Riccabona et al (16) reported that before the introduction of iodine prophylaxis the thyroid cancers seen were often aggressive and advanced with a poor prognosis and that this trend was reversed after the introduction of iodine proplylaxis. The aggressive biological behaviour of thyroid cancers in endemic areas might be explained by sustained TSH stimulation of the thyroid gland which has been reported to transform differentiated, slow growing, endocrine-dependent tumours into rapidly growing, autonomously functioning, metastasizing tumows (17,18).…”

Section: Discussionmentioning

confidence: 99%