The Endocrine Cells in the Human Pyloric Antrum. An Electron Microscope Study of Biopsy Materials

Sasagawa, Tsutomu; Kobayashi, Shigeru; Fujita, Tsuneo

doi:10.1679/aohc1950.32.275

Cited by 44 publications

(6 citation statements)

References 19 publications

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“…The presence of D1 cells deep in the pyloric glands was affirmed by the estab lished criteria -secretory granules with elec tron-dense cores and a clear peripheral space [Ericson et al, 1972a, b;Kobayashi et al, 1971;Forssman, 1970], as well as by the presence of microfilament bundles, espe cially in the perinuclear region [Sasagawa et al, 1970]. The granular characteristics of D1 cells are reminiscent of noradrenalin-containing adrenomedullary tissues, and these cells have been considered to contain catecholamines [Forssman et al, 1969].…”

Section: Discussionmentioning

confidence: 99%

An Ultrastructural and Cytochemical Study of Enteroendocrine Cells of the Pyloric Antrum in the Gerbil, <i>Meriones unguiculatus</i>

Kapur¹

1982

Cells Tissues Organs

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Enteroendocrine cells of the gastric antrum have been examined in the gerbil, Meriones unguiculatus. Gastrin-secreting G cells were identified by immunocytochemical methods and by transmission electron microscopy. They were present in the lower and middle third of the pyloric antral glands. G cells were polyhedral in shape and often extended to the gland lumen where they presented a microvillous and pinocytotic surface. These cells were characterized by numerous electron-dense and immunoreactive secretory granules. Enterochromaffin cells were identified by a serotonin-specific formaldehyde-induced fluorescence method, and by electron microscopy which revealed pleomorphic secretory granules of varying electron densities. These cells also had luminal projections and had a shape and distribution essentially similar to those of the G cells. A third endocrine cell type was identified as Dl cell in the pyloric glands. This cell type was recognized by the presence of numerous secretory granules having an electron-dense core and a clear peripheral space, as also by the presence of microfilament bundles, especially in the peri-nuclear region. The functional correlates of these morphological observations are discussed with reference to their secretory product and the manner of its release, especially by the G cells.

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Section: Discussionmentioning

confidence: 99%

An Ultrastructural and Cytochemical Study of Enteroendocrine Cells of the Pyloric Antrum in the Gerbil, <i>Meriones unguiculatus</i>

Kapur¹

1982

Cells Tissues Organs

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“…Endocrine cells of human gastric mucosa showing similar granules have been classified as enterochromaffin cells [Kobayashi et al, 1971;Vassallo el al., 1971;Rubin, 1972a, b]. Another frequently observed endocrine cell type in the pyloric glands con tains smaller, less electron-dense granules which appear morphologically similar to either the gastrin cell [Vasallo et al, 1972;Greideret al, 1972] or a type III endocrine cell [Sasagawa et al, 1970]. An infrequently ob served endocrine cell exhibits large, round granules of moderate electron density and is thought to correspond to the D cell [Sasr/gau a el al., 1970;Kobayashi el al., 1971: Vassallo et al, 1971: Rubin, 1972a.…”

Section: Discussionmentioning

confidence: 99%

Ultrastructure of the human pyloric glands with emphasis on the mucous cell component

Krause¹,

Ivey²,

Baskin³

et al. 1977

Cells Tissues Organs

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The human pyloric glands are simple or branched tubular glands which spiral through the connective tissue of the lamina propria. They are comprised of three cell types: the pyloric gland (mucous) cell, the parietal cell, and endocrine cells. The mucous cell is the most common cell type in the human pyloric glands and is characterized by an abundance of secretory granules. The secretory granules are usually round in shape and vary considerably in diameter. They are membrane-bound and comprise a heterogeneous population. The larger granules contain a light staining amorphous material and often possess an area of increased electron density near the limiting membrane of the granule giving them a mottled appearance. A smaller, more electron-dense secretory granule also is found both in relation to the Golgi complex and cell apex.The morphological observations indicate that the mechanism of mucin production by the mucous cells of the human pyloric glands may be similar to that reported in other mucin-secreting cells.

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“…It is generally accepted that the glycosilation of a protein is processed sequentially during its transport from the rough endoplasmic reticulum (RER) toward and through the Golgi complex, and the addition of terminal sugars such as sialic acid occurs just before the protein exits from the Golgi complex (Kornfeld and Kornfeld, 1985). In gastrointestinal endocrine cells, RER and the Golgi complex are located predominantly in the surpranuclear cytoplasm, whereas secretory granules are mostly localized in the infranuclear region Sasagawa et al, 1970). A recent electron microscopic study of pituitary adenomas by Osamura et al (1988) has shown that CGA is localized not only in secretory granules but also in RER.…”

Section: Discussionmentioning

confidence: 99%

Localization of Chromogranin A-Immunoreactivity in Bovine Gastrointestinal Endocrine Cells with Special Reference to Grimelius Silver Stain.

et al. 1990

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The Endocrine Cells in the Human Pyloric Antrum. An Electron Microscope Study of Biopsy Materials

Cited by 44 publications

References 19 publications

An Ultrastructural and Cytochemical Study of Enteroendocrine Cells of the Pyloric Antrum in the Gerbil, <i>Meriones unguiculatus</i>

An Ultrastructural and Cytochemical Study of Enteroendocrine Cells of the Pyloric Antrum in the Gerbil, <i>Meriones unguiculatus</i>

Ultrastructure of the human pyloric glands with emphasis on the mucous cell component

Localization of Chromogranin A-Immunoreactivity in Bovine Gastrointestinal Endocrine Cells with Special Reference to Grimelius Silver Stain.

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