The endocannabinoid system: Role in glucose and energy metabolism

Nogueiras, Rubén; Díaz-Arteaga, Adenis; Lockie, Sarah H.; Velásquez, Douglas A; Tschöp, Johannes; López, Miguel; Cadwell, Charles C; Diéguez, Carlos; Tschöp, Matthias H.

doi:10.1016/j.phrs.2009.04.004

Cited by 55 publications

(49 citation statements)

References 61 publications

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“…Endocannabinoids exert their functions by binding to two cannabinoid receptors: CB-1 and CB-2 (Nogueiras et al, 2009). Apart from regulating appetite, and thus food intake, endocannabinoids participate in the control of lipid and glucose metabolism, and its dysregulation in obesity contributes to fat accumulation and associated metabolic disorders (Bluher et al, 2006;Di Marzo, 2008).…”

Section: Endocannabinoidsmentioning

confidence: 99%

Role of bioactive lipid mediators in obese adipose tissue inflammation and endocrine dysfunction

Lopategi

López‐Vicario

Alcaraz‐Quiles

et al. 2016

Molecular and Cellular Endocrinology

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a b s t r a c tWhite adipose tissue is recognized as an active endocrine organ implicated in the maintenance of metabolic homeostasis. However, adipose tissue function, which has a crucial role in the development of obesity-related comorbidities including insulin resistance and non-alcoholic fatty liver disease, is dysregulated in obese individuals. This review explores the physiological functions and molecular actions of bioactive lipids biosynthesized in adipose tissue including sphingolipids and phospholipids, and in particular fatty acids derived from phospholipids of the cell membrane. Special emphasis is given to polyunsaturated fatty acids of the omega-6 and omega-3 families and their conversion to bioactive lipid mediators through the cyclooxygenase and lipoxygenase pathways. The participation of omega-3-derived lipid autacoids in the resolution of adipose tissue inflammation and in the prevention of obesity-associated hepatic complications is also thoroughly discussed.

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Section: Endocannabinoidsmentioning

confidence: 99%

Role of bioactive lipid mediators in obese adipose tissue inflammation and endocrine dysfunction

Lopategi

López‐Vicario

Alcaraz‐Quiles

et al. 2016

Molecular and Cellular Endocrinology

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“…Moreover, follicular fluid AEA concentrations are correlated with follicle size and are lower in follicles from which oocytes are not retrieved, indicating that AEA is probably involved in the maturation of the follicles and the oocytes (Schuel et al 2002, El-Talatini et al 2007. It is well known that the endocannabinoid system regulates energy balance by modulating appetite, food intake and glucose metabolism (Bellocchio et al 2007, Nogueiras et al 2009). Some evidence also suggests that the endocannabinoid system could interact with ovary function through the modulation of pathways involved in energy balance and metabolism control.…”

Section: The Endocannabinoid System and The Ovarymentioning

confidence: 99%

The endocannabinoid pathway and the female reproductive organs

Blasio¹,

Vignali²,

Gentilini³

2012

Journal of Molecular Endocrinology

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Endocannabinoids are endogenous ligands of cannabinoid, vanilloid and peroxisome proliferator-activated receptors that activate multiple signal transduction pathways. Together with their receptor and the enzymes responsible for their synthesis and degradation, these compounds constitute the endocannabinoid system that has been recently shown to play, in humans, an important role in modulating several central and peripheral functions including reproduction. Given the relevance of the system, drugs that are able to interfere with the activity of endocannabinoids are currently considered as candidates for the treatment of various diseases. In this review, we will summarise the current knowledge regarding the effects of endocannabinoids in female reproductive organs. In particular, we will focus on some newly reported mechanisms that can affect endometrial plasticity both in physiological and in pathological conditions.

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“…Because of the ubiquitous expression of the receptor throughout the CNS, several preclinical and clinical studies have addressed the potential therapeutic value in modulating the endocannabinoid system for analgesia, weight loss, appetite stimulation, neuroprotection after ischemic injuries, and for anti-emetic, anti-epileptic and antispasmodic purposes (Nogueiras, Diaz-Arteaga et al 2009;Bisogno and Di Marzo 2010;Karst, Wippermann et al 2010;Scotter, Abood et al 2010). The premise of many of these therapeutic approaches lies in the neuromodulatory function of CB1R, or in the antiinflammatory effects on CB2R activation.…”

Section: Role Of Cannabinoid Receptors During Pathological Statesmentioning

confidence: 99%