The endocannabinoid 2-arachidonoylglycerol is released and transported on demand via extracellular microvesicles
Verena M. Straub,
Benjamin Barti,
Sebastian T. Tandar
et al.
Abstract:While it is known that endocannabinoids (eCB) modulate multiple neuronal functions, the molecular mechanism governing their release and transport remains elusive. Here, we propose an 'on-demand release' model, wherein the formation of microvesicles, a specific group of extracellular vesicles (EVs) containing the eCB, 2-arachidonoylglycerol (2-AG), is the rate-limiting step. A co-culture model system that combines a reporter cell line expressing the fluorescent eCB sensor, GRABeCB2.0, and neuronal cells reveale… Show more
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