The Encephalitis Periaxialis of Schilder. A Clinical and Pathological Study, With an Account of Two Cases, One of Which Was Diagnosed During Life

A Form of Progressive Cerebral Sclerosis in Infants Associated With Primary Degeneration of the Interfascicular Glia

“…They suggest that the origin of the trouble may lie in the circulation of abnormal lipoids in the blood, which are unsuitable for the formation or nutrition of myelin. Collier and Greenfield (1924) suggested that Schilder's disease, in the familial case which they studied, was due to a primary affection of those neuroglial cells in the white matter which had to do with the nutrition of the myelin sheaths. The nutritive function of the oligodendroglia towards myelin was not recognised at this time, and in fact the first English description of oligodendroglia appeared in the same number of Brain.…”

Krabbe disease: One Hundred years from the bedside to the bench to the bedside

“…There had been at least one earlier report of patients with similar histopathological changes who may have had the same disease (Bullard and Southard, ). In 1924, Collier and Greenfield () described the globular distended multinucleated bodies (globoid cells), which are a histopathological characteristic of this disease, in the brains of these patients. However, it is interesting that these features were seen in patients who had a later‐onset form of the disease (onset at 4.5 and 6 years of age).…”

Diagnosis of Krabbe's infantile leucodystrophy

“…In cases 1 and 2 detailed histological and histochemical studies were carried out on the nervous system, endocrine, and visceral organs. The presence of numerous epitheloid or globoid cells already described by Beneke (1908), Krabbe (1916), and Collier and Greenfield (1924) in the extensively demyelinated white matter of the brain was the most remarkable and pathognomonic feature. Most of the globoid cells occurred in clusters around capillaries and venules.…”