The enabled homolog gene polymorphisms are associated with susceptibility and progression of childhood IgA nephropathy

Abstract

The enabled homolog gene (ENAH, hMena) is abundantly expressed in mesangial tissue, and might play an important role in inflammatory processes of IgA nephropathy (IgAN). The present study was conducted to investigate the association between single nucleotide polymorphisms (SNPs) of the ENAH and childhood IgAN. We analyzed 12 SNPs of ENAH in 176 patients with childhood IgAN and 397 healthy controls. In addition, IgAN patients were dichotomized and compared with respect to several clinical and pathological parameters. Genotyping data showed significant differences between IgAN patients and controls in the frequency of rs2039620, rs12034829, and rs3795443. On comparison of patients with proteinuria to those without proteinuria (≤ or ＞ 4 mg/m 2 /h), rs12043633 was significantly different between the two groups. With regard to maximum proteinuria (≤ or ＞ 4 mg/m 2 /h), rs3795443, rs4653643, rs6751, rs10799319, rs7555139, rs576861, and rs487591 showed significant allele frequency differences. For patients with and without gross hematuria, rs4653643, rs6751, rs10799319, rs7555139, rs576861, and rs487591 showed significant allele frequency differences. The rs3795443 was found to be associated with progression of pathological findings. Our results suggest that ENAH polymorphisms are associated with increased susceptibility, development of proteinuria and gross hematuria, and pathological progression of childhood IgAN.

Association between toll-like receptor 10 (TLR10) gene polymorphisms and childhood IgA nephropathy

“…All IgAN patients with prolonged hematuria or concomitant proteinuria were examined by kidney biopsy. IgAN patients were divided according to presence or absence of proteinuria at kidney biopsy (>4 mg/m 2 /h) [10,11], gross hematuria episodes as an initial symptom of IgAN, and advanced pathological disease markers (interstitial fibrosis, tubular atrophy, or global sclerosis), respectively. The control group was recruited from subjects visiting the hospital for routine health checkups.…”

IgA Nephropathy Precedes the Onset of the Rheumatic Disease in a Female with Ankylosing Spondylitis

“…A-31 year old Indian and a mother of one child was referred spondyloarthropathies such as Behcet's disease, psoriatic arthritis, Reiter's syndrome and the postenteritic arthritides have been previously reported [5,6,10,12,13].…”

IgA Nephropathy Precedes the Onset of the Rheumatic Disease in a Female with Ankylosing Spondylitis

“…Although the condition is a limited non-systemic renal disease, some systemic diseases are sporadically associated with mesangial IgA deposition. Henoch-Schonlen purpura (HSP), systemic lupus erythematosus (SLE), hepatitis, dermatitis herpetiformis, celiac disease and ankylosing spondylitis ( AS) have been closely linked to the IgA nephropathy [6,7].…”

“…spondyloarthropathies such as Behcet's disease, psoriatic arthritis, Reiter's syndrome and the postenteritic arthritides have been previously reported [5,6,10,12,13].…”