The emu oil emulsified in egg lecithin and butylated hydroxytoluene enhanced the proliferation, stemness gene expression, and in vitro wound healing of adipose-derived stem cells

Arezoumand, Khatereh Saei; Esmaeillou, Mohammad; Ghasemi, Maryam; Alipour, Shahriar; Pilehvar-Soltanahmadi, Younes; Zarghami, Nosratollah

doi:10.1007/s11626-018-0228-8

Cited by 11 publications

(3 citation statements)

References 55 publications

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“…Stem cells can be also pretreated by various chemicals like for example emu oil emulsified in egg lecithin and butylated hydroxytoluene. Such conditioning significantly increased the regenerative potential of ADSCs and even affected their cell cycle, which was proven by many different tests in vitro (Arezoumand et al, 2018).…”

Section: Pretreatment and Co-culture Of Stem Cellsmentioning

confidence: 94%

Novel trends in application of stem cells in skin wound healing

Kucharzewski

Rojczyk

Wilemska-Kucharzewska

et al. 2019

European Journal of Pharmacology

154

118

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The latest findings indicate the huge therapeutic potential of stem cells in regenerative medicine, including the healing of chronic wounds. Main stem cell types involved in wound healing process are: epidermal and dermal stem cells, mesenchymal stem cells (MSCs), endothelial progenitor cells (EPCs) and hematopoietic stem cells (HSCs). In the therapy of chronic wounds, they can be administrated either topically or using different matrix like hydrogels, scaffolds, dermal substitutes and extracellular matrix (ECM) derivatives. Stem cells are proven to positively influence wound healing by different direct and indirect mechanisms including residing cells stimulation, biomolecules release, inflammation control and ECM remodelling. MSCs are especially worth mentioning as they can be easily derived from bone-marrow or adipose tissue. Apart from traditional approach of administering living stem cells to wounds, new trends have emerged in recent years. Good healing results are obtained using stem cell secretome alone, for example exosomes or conditioned media. There are also attempts to improve healing potential of stem cells by their co-culture with other cell types as well as by their genetic modifications or pretreatment using different chemicals or cell media. Moreover, stem cells have been tested for novel therapeutic purposes like for example acute burns and have been used in experiments on large animal models including pigs and sheep. In this review we discuss the role of stem cells in skin wound healing acceleration. In addition, we analyse possible new strategies of stem cells application in treatment of chronic wounds.

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Section: Pretreatment and Co-culture Of Stem Cellsmentioning

confidence: 94%

Novel trends in application of stem cells in skin wound healing

Kucharzewski

Rojczyk

Wilemska-Kucharzewska

et al. 2019

European Journal of Pharmacology

154

118

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“… 24 , 25 The application of PRP combined with other therapeutic techniques, such as negative pressure wound therapy (NPWT), ASCs transplantation, and genetic engineering biotechnology, would further improve the therapeutic effect of wounds. 26 , 27 , 28 …”

Section: Discussionmentioning

confidence: 99%

Research trends on platelet‐rich plasma in the treatment of wounds during 2002–2021: A 20‐year bibliometric analysis

Lai

Chen

Zhang

et al. 2022

International Wound Journal

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Platelet-rich plasma (PRP) has attracted attention because of its potential to accelerate the wound healing process. However, resources for evaluating research trends in the treatment of wounds with PRP were limited. In this study, we aimed to make a bibliometric analysis of the literature related to PRP in the treatment of wounds and explore the research status, hotspots and frontiers in this field in recent 20 years. Studies about PRP treatment for wounds from 2002 to 2021 were retrieved from the Science Citation Index Expanded (SCI-E) of Web of Science (WOS) database. Visualisation softwares such as VOSviewer and SCImago Gra-

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“…The process of wound repair often results in replacement of the outermost layer of skin, mucous membranes, or fetal skin. The healing of skin involves a nonspecific kind of repair, in which the wound is closed by the formation of scar tissue, a nonfunctional mass of fibrotic tissue. , It is estimated that almost 400 million individuals experience acute wounds each year, encompassing traumatic wounds, burns, and surgical wounds . Patients with diabetes may experience delayed wound healing, which can lead to a heightened susceptibility to infection and the emergence of potentially severe symptoms.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Wound Healing 3D Structure Based on Chitosan Hydrogel Loaded with Naringin/Cyclodextrin Inclusion Nanocomplex

Bian,

Pilehvar,

Kousha

et al. 2024

ACS Omega

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The current assay aimed to fabricate and analyze a potent wound healing structure based on a naringin (Nar)/β-cyclodextrin (β-CD)-loaded chitosan hydrogel. Using the simulation studies, we assessed the interactions among the Nar, β-CD, and the formation of the inclusion complex. Then, the formation of the hydrogel nanocomplex was simulated and evaluated using the in silico methods. The results showed that after optimization of the structures by DMol3 based on DFT-D, the total energies of Nar, GP, CD, and β-CD were calculated at −2100. 159, −912.192, −3778.370, and −4273.078 Ha, respectively. The encapsulation energy of Nar on β-CD in the solvent phase was calculated at −93.626 kcal/mol, and the Nar structure was located inside β-CD in solution. The negative interaction energy value for the encapsulation of Nar on β-CD suggests the exothermic adsorption process and a stable structure between Nar and β-CD. Monte Carlo method was applied to obtain adsorption of CS/GP on Nar/β-CD. Its value of the obtained interaction energy was calculated at −1.423 × 103 kcal/mol. The characterization confirmed the formation of a Nar/β-CD inclusion complex. The Zeta potential of the pristine β-CD changed from −4.60 ± 1.1 to −17.60 ± 2.34 mV after interaction with Nar, and the heightened surface negativity can be attributed to the existence of electron-rich naringin molecules, as well as the orientation of the hydroxyl (OH) group of the β-CD toward the surface in an aqueous solution. The porosity of the fabricated hydrogels was in the range of 70−90% and during 14 days around 47.0 ± 3.1% of the pure hydrogel and around 56.4 ± 5.1 of hydrogel nanocomposite was degraded. The MTT assay showed that the hydrogels were biocompatible, and the wound contraction measurement (in an animal model) showed that the closure of the induced wound in the hydrogel nanocomposite treatment was faster than that of the control group (wound without treatment). The results of this study indicate that the developed bioactive wound healing 3D structure, which is composed of a chitosan hydrogel containing a Nar/β-CD inclusion nanocomplex, has potential as an effective material for wound dressing applications.

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The emu oil emulsified in egg lecithin and butylated hydroxytoluene enhanced the proliferation, stemness gene expression, and in vitro wound healing of adipose-derived stem cells

Cited by 11 publications

References 55 publications

Novel trends in application of stem cells in skin wound healing

Novel trends in application of stem cells in skin wound healing

Research trends on platelet‐rich plasma in the treatment of wounds during 2002–2021: A 20‐year bibliometric analysis

Bioactive Wound Healing 3D Structure Based on Chitosan Hydrogel Loaded with Naringin/Cyclodextrin Inclusion Nanocomplex

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