2011
DOI: 10.1182/blood-2010-08-300236
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The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization

Abstract: IntroductionZeb2 (also known as Sip1 and Zfhx1b) is a DNA-binding transcriptional regulator of the family of zinc-finger E-box-binding (ZEB) proteins. 1,2 Its expression and functioning during development have been associated with epithelial-to-mesenchymal transitions (EMTs). 3 EMTs encompass a series of events in which polarized epithelial cells become round in shape, lose their cell-cell contacts, and acquire the motile, migratory properties of mesenchymal cells. 4 This physiologic process is essential for m… Show more

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Cited by 94 publications
(91 citation statements)
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“…Moderate to high Zeb2 expression is reported in all hematopoietic cells with highest levels in stem (HSC) and progenitor (HPC) populations (Goossens et al, 2011) and lowest expression in mature T cells (Postigo & Dean, 2000). Through the use of a conditional Zeb2 knockout mouse (Higashi et al, 2002) model we could show that it is not essential for the initial formation of HSCs in the embryo but it is crucial for HSC differentiation and mobilization/homing (Goossens et al, 2011).…”
Section: Role Of Zeb2 In Hematopoietic Stem/progenitor Differentiatiomentioning
confidence: 94%
See 1 more Smart Citation
“…Moderate to high Zeb2 expression is reported in all hematopoietic cells with highest levels in stem (HSC) and progenitor (HPC) populations (Goossens et al, 2011) and lowest expression in mature T cells (Postigo & Dean, 2000). Through the use of a conditional Zeb2 knockout mouse (Higashi et al, 2002) model we could show that it is not essential for the initial formation of HSCs in the embryo but it is crucial for HSC differentiation and mobilization/homing (Goossens et al, 2011).…”
Section: Role Of Zeb2 In Hematopoietic Stem/progenitor Differentiatiomentioning
confidence: 94%
“…Through the use of a conditional Zeb2 knockout mouse (Higashi et al, 2002) model we could show that it is not essential for the initial formation of HSCs in the embryo but it is crucial for HSC differentiation and mobilization/homing (Goossens et al, 2011). Hematopoietic-specific Zeb2 loss-of-function resulted in embryonic lethality resulting from bleedings occurring in the developing brain.…”
Section: Role Of Zeb2 In Hematopoietic Stem/progenitor Differentiatiomentioning
confidence: 99%
“…For simplicity, the Zeb2 flox/flox ; GzmB-cre + mice will be referred to as Zeb2 −/− mice and Zeb2 flox/flox ; GzmB-cre − or Zeb +/+ ; GzmB-cre + littermate controls will be referred to as WT mice. It was important to use a conditional knock-out strategy because Zeb2 −/− mice show embryonic lethality and Zeb2 is expressed in many cell types, including hematopoietic stem cells, NK cells, monocytes, and mast cells (Tylzanowski et al, 2003;van Grunsven et al, 2006;Goossens et al, 2011;Barbu et al, 2012;Best et al, 2013). Zeb2 was efficiently deleted in ∼85-90% of the polyclonal CD44 hi CD8 + T cells using this system (unpublished data).…”
Section: Res Ults Zeb2 Is Expressed In Klrg1 Hi Cd8 + T Cells In a T-mentioning
confidence: 99%
“…17,27 To more specifically study the effects of p53 deletion on the endothelium, Tie2-Cre transgenic mice, 22 in which Cre recombinase is active in both the endothelium and the hematopoietic system, 28 were crossed with conditional p53 fl/fl mice. 23 The resultant Tie2-Cre, p53 fl/fl mice developed tumors by the average age of 25 wk (Fig.…”
Section: Tie2-cre P53mentioning
confidence: 99%