The Emerging Role of the Interactions between Circular RNAs and RNA-binding Proteins in Common Human Cancers

Jiang, Meng-Ping; Xu, Wen‐Xiu; Hou, Jianglong; Xu, Qi; Wang, Dandan; Tang, Jinhai

doi:10.7150/jca.58182

Cited by 19 publications

(12 citation statements)

References 111 publications

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“…To date, circRNAs have been proposed to function through several molecular mechanisms, including (i) miRNA sponging, (ii) mRNA regulation at both translational and transcriptional levels, (iii) interacting with proteins to form circRNA-protein complexes, and (iv) translation into a peptide or a protein 84 - 86 . However, circRNA binding to mRNA and proteins is often taking place at odds and not always concordant.…”

Section: Functional Mechanisms Of Circrnas Associated With Hippo-yap ...mentioning

confidence: 99%

“…However, circRNA binding to mRNA and proteins is often taking place at odds and not always concordant. Interestingly, most of the studies involving circRNAs have been in the field of cancer 21 , 84 , 87 . Thus far, only a handful of studies have reported about the circRNAs regulating the Hippo-YAP signaling pathway.…”

Section: Functional Mechanisms Of Circrnas Associated With Hippo-yap ...mentioning

confidence: 99%

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Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer

Qadir¹,

Li²,

Yang³

2022

Theranostics

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The Hippo signaling pathway is an evolutionarily conserved network that regulates organ size and tissue homeostasis in mammals. This pathway controls various cell functions, such as growth, proliferation, survival, apoptosis, and stemness by switching 'on' or 'off' its inhibitory and/or transcriptional module, thereby regulating target gene(s) expression. Altered Hippo signaling has been implicated in various forms of cancers. Increasing evidence suggests cross-talk between the Hippo signaling pathway and non-coding RNAs, in particular circular RNAs (circRNAs). In this context, the current review presents the mechanistic interplay between the Hippo pathway and related circRNAs in various forms of cancers, along with the capabilities of these circRNAs to function either as tumor suppressors or oncogenes through miRNA sponging or protein binding mechanisms. Furthermore, we discuss the constraints and limitations in circRNA mechanistic studies while highlighting some outstanding questions regarding the roles of circRNAs associated with the Hippo-YAP pathway in cancer. Finally, we delineate the potential of these circRNAs to be employed as diagnostic and prognostic biomarkers, as well as molecular hotspots for cancer therapy.

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Section: Functional Mechanisms Of Circrnas Associated With Hippo-yap ...mentioning

confidence: 99%

Section: Functional Mechanisms Of Circrnas Associated With Hippo-yap ...mentioning

confidence: 99%

Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer

Qadir¹,

Li²,

Yang³

2022

Theranostics

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“…Numerous previous studies have shown that circRNAs can exert their functions by binding to and acting on proteins, especially RNA-binding proteins (RBPs) by functioning as a sponge, decoy, or scaffold [ 43 , 44 ]. To understand the mechanism by which the hsa_circ_0062682 exerts its oncogenic potential in HCC we wanted to investigate potential protein binding partners.…”

Section: Resultsmentioning

confidence: 99%

Circular RNA hsa_circ_0062682 Binds to YBX1 and Promotes Oncogenesis in Hepatocellular Carcinoma

Razpotnik

Vidmar

Fonović

et al. 2022

Cancers

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Circular RNAs (circRNAs) have been shown to play an important role in the pathogenesis of hepatocellular carcinoma (HCC). By implementing available transcriptomic analyses of HCC patients, we identified an upregulated circRNA hsa_circ_0062682. Stable perturbations of hsa_circ_0062682 in Huh-7 and SNU-449 cell lines influenced colony formation, migration, cell proliferation, sorafenib sensitivity, and additionally induced morphological changes in cell lines, indicating an important role of hsa_circ_0062682 in oncogenesis. Pathway enrichment analysis and gene set enrichment analysis of the transcriptome data from hsa_circ_0062682 knockdown explained the observed phenotypes and exposed transcription factors E2F1, Sp1, HIF-1α, and NFκB1 as potential downstream targets. Biotinylated oligonucleotide pulldown combined with proteomic analyses identified protein interaction partners of which YBX1, a known oncogene, was confirmed by RNA immunoprecipitation. Furthermore, we discovered a complex cell-type-specific phenotype in response to the oncogenic potential of hsa_circ_0062682. This finding is in line with different classes of HCC tumours, and more studies are needed to shed a light on the molecular complexity of liver cancer.

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“…Apart from miRNAs, circRNAs also regulate target mRNAs and their translation by sequestering RNA binding proteins (RBPs) [ 84 ]. However, little is known on the role of circRNA-RBP interactions in promoting invasion and metastasis in cancer [ 85 ]. In a recent study, a novel circRNA, circ0005276, was shown to enhance cell proliferation, EMT, and migration in prostate cancer by interacting with FUS RBP.…”

Section: Molecular Homeostasis Signaling In Cancer Hallmarksmentioning

confidence: 99%

Circular RNAs Modulate Cancer Hallmark and Molecular Pathways to Support Cancer Progression and Metastasis

Yarmishyn

Ishola

Chen

et al. 2022

Cancers

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Circular RNAs (circRNAs) are noncoding products of backsplicing of pre-mRNAs which have been established to possess potent biological functions. Dysregulated circRNA expression has been linked to diseases including different types of cancer. Cancer progression is known to result from the dysregulation of several molecular mechanisms responsible for the maintenance of cellular and tissue homeostasis. The dysregulation of these processes is defined as cancer hallmarks, and the molecular pathways implicated in them are regarded as the targets of therapeutic interference. In this review, we summarize the literature on the investigation of circRNAs implicated in cancer hallmark molecular signaling. First, we present general information on the properties of circRNAs, such as their biogenesis and degradation mechanisms, as well as their basic molecular functions. Subsequently, we summarize the roles of circRNAs in the framework of each cancer hallmark and finally discuss the potential as therapeutic targets.

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The Emerging Role of the Interactions between Circular RNAs and RNA-binding Proteins in Common Human Cancers

Cited by 19 publications

References 111 publications

Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer

Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer

Circular RNA hsa_circ_0062682 Binds to YBX1 and Promotes Oncogenesis in Hepatocellular Carcinoma

Circular RNAs Modulate Cancer Hallmark and Molecular Pathways to Support Cancer Progression and Metastasis

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