Abstract:Diabetes mellitus has been accepted as an epidemic worldwide during the last two decades. Despite the diagnostic tools and therapeutic approaches, the pathophysiology of this metabolic disorder and cellular defensive mechanisms remain mysterious. The maintenance of cellular homeostasis requires well-organized network between glucose, amino acid and lipid metabolism. Sirtuins are a group of nicotinamide adenine dinucleotide dependent proteins that are involved in cellular homeostasis by their deacetylating acti… Show more
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